1,234 research outputs found
Conflicts of misfit children in Ini Kisah Adham, Saya & Awan Shiro by Mazny M. R. : a struggle for love, comfort and happiness
No full textThis research aims to discuss conflicts of misfit children, having struggled in their small community as illustrated in the novel Ini Kisah Adham, Saya & Awan Shiro (‘This is the story of Adham, Awan Shiro and me’). The term ‘conflict’ is widely understood as collision or disagreement within oneself or involving at least two parties over one particular need. Consequently, one is battling with obstacles to achieve the need, hence gradually requires him to make the best decision or to commit the most possible action. The research outlines three objectives to achieve, (1) to identify the characters of misfit children in Ini Kisah Adham, Saya & Awan Shiro by Mazny M. R.; (2) to analyse the conflicts circulated around the misfit children in Ini Kisah Adham, Saya & Awan Shiro by Mazny M. R, and (3) to relate the conflicts of misfit children with the struggle for love, comfort and happiness Ini Kisah Adham, Saya & Awan Shiro by Mazny M. R. This research employs close reading method. The primary source of the research is the novel Ini Kisah Adham, Saya & Awan Shiro by Mazny M. R., first published by The New Straits Times Press (Malaysia) in 2019. The novel is an award winning work, having been the first prize winner of Sayembara Novel Remaja & Kanak-kanak Berita Harian (a novel writing contest for young adults and children organized by Berita Harian). The secondary sources of the research include journals, books, articles, references or other sources that enable further understanding on the issues highlighted in the primary source. To clarify further on ‘conflicts’ that surround the misfit characters, the research employs the theory of conflicts by Neal E. Miller. Miller outlines four types of conflicts that usually one needs to confront in his/her life: (1) approach – avoidance competiton (2) avoidance – avoidance competition (3) approach – approach competition and (4) double approach – avoidance competiton. The results indicate that the two misfit children found in the novel, Hiro and Adham, are psychologically and emotionally distrupted at their school and home after their parents’ death/divorce. Furthermore, the conflicts also happen due to the inability of adults to comprehend conflicts from the children’s perspectives. The bonding of the boys later on convince them to help each other to finally win their struggle for love, comfort and happiness
Impairment of gastric acid secretion and increase of embryonic lethality in Foxq1-deficient mice
No full textThe mouse Foxq1 gene, also known as Hfh1, encodes a winged helix/forkhead transcription factor. In adult mice, Foxq1 is highly expressed in kidney and stomach. Here, we report that Foxq1 is expressed during prenatal and postnatal stomach development and the transcripts are restricted to acid secreting parietal cells. Mice homozygous for a deletion of the Foxq1 locus on a 129/Sv x C57BL/6J hybrid genetic background display variable phenotypes consistent with requirement of the gene during embryogenesis. Approximately 50% of Foxq1-/- embryos die in utero. Surviving homozygous mutants are normal and fertile, and have a silky shiny coat. Although the parietal cell development is not affected in the absence of Foxq1, there is a lack of gastric acid secretion in response to various secretagogue stimuli. Ultrastructural analysis suggests that the gastric acid secretion defect in Foxq1-deficient mice might be due to impairment in the fusion of cytoplasmic tubulovesicles to the apical membrane of secretory canaliculi
Mouse pelota gene (Pelo): cDNA cloning, genomic structure, and chromosomal localization
No full textThe pelota gene of Drosophila melanogaster encodes a protein which is included in cell cycle regulation. Mutations were found to result in spermatogenic arrest, female sterility and disturbances in the patterning of the e e. We have recently isolated and characterized cDNA clones coding for the human pelota gene (PELO). Here we describe the cloning of the murine pelota cDNA and gene (Pelo) that encodes a 385-amino-acid protein. The exon-intron structure of the gene, which contains three exons, was determined. Comparison of the mouse amino acid sequences with the human and Drosophila sequences revealed an overall high identity (96% and 70%, respectively). Northern blot analysis detected a 1.7-kb transcript in all tissues studied. Southern blot analyses revealed that the pelota gene is present as a single copy in the mouse genome. The mouse pelota gene (Pelo) was mapped to the distal end of chromosome 13, in a region that is homologous with a segment of human chromosome 5q11 containing the orthologous human gene. Cloning of the mouse gene is an important step to study the function of the pelota gene in mammals and to create a mouse model for this evolutionarily conserved gene. Copyright (C) 2002 S. Karger AG, Basel
Insulin-like 3 signalling in testicular descent
No full textUndescended testis is one of the most common congenital defects in the newborn boys and the common cause of cryptorchidism. If left untreated, this condition is strongly associated with infertility and drastically increased risk of testicular cancer in adulthood. Testis position in developing males is defined by sexual dimorphic differentiation of two gonadal ligaments, gubernaculum and cranial suspensory ligament. Recent transgenic mouse studies identified testicular hormone insulin-like 3 (INSL3), and its receptor, GREAT/LGR8, as the critical regulators of the gubernacular differentiation. Mutation analysis of the two genes in patients with undescended testis revealed functionally deleterious mutations, which may be responsible for the abnormal phenotype in some of the patients.NICHD NIH HHS [HD36289, HD37067, R01 HD037067, R01 HD037067-04
Syria's predicament : state (de-) formation and international rivalries
No full textSyria’s war raises important questions about the interaction between the domestic and external dimensions of the conflict. What are the main areas of contention, and how do they relate to regional and international dynamics? Why has the conflict developed into a regional and international battle, and who are the main actors in this rivalry? And, finally, what are the realistic options for ending the Syrian war? The aim of this paper is to answer these questions. In the first, the author examines the domestic origins of the Syrian crisis by focusing on the process of state formation and deformation in Syria. Then, he considers the main areas of contention that shape the Syrian civil war and its regional and international dimensions. Finally, he assesses the conditions under which Syria – as a divided state in a polarised region – can end the war. He argues that in the absence of a military solution to the war in Syria, a political solution may be the only hope for ending the crisis; but such a solution is fraught by varying domestic and external interests in Syria.Peer reviewe
The role of the testicular factor INSL3 in establishing the gonadal position
No full textINSL3, also designated Leydig insulin-like (Ley I-L) or relaxin-like factor (RLF), belongs to the insulin-like hormone superfamily. It is expressed in pre- and postnatal Leydig cells of the testis and in postnatal theca cells of the ovary. This sexual dimorphic pattern of INSL3 expression during development led us to suggest that the INSL3 factor could play an essential role in sexual differentiation, gonadal function and germ cell development. Key insights into the role of INSL3 came from analyses of INSL3 knockout mice. These mice showed impaired development of the gubernaculum ligament, a structure that is believed to mediate transabdominal descent of the testis during male embryogenesis. In double mutant XY-mice lacking INSL3 and a functional androgen receptor, it was demonstrated that both are essential for establishment of the sexual dimorphic position of the gonads through regulation of gubernaculum development and regression of the cranial suspensory ligament (CSL) during fetal life. Defects in this developmental process can cause cryptorchidism in the male, which is a most common disorder of sexual differentiation in human. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved
Corrigendum to “The 2016 update of the International Study Group (ISGPF) definition and grading of postoperative pancreatic fistula: eleven years after.” Surgery 2017. Mar; 161 (3):584–591. Epub Dec 28, 2016 (Surgery (2017) 161(3) (584–591), (S0039606016307577), (10.1016/j.surg.2016.11.014))
No full textThe authors regret that the name of author Charles R. Vollmer MD is incorrect in the final published version. The correct name Charles Vollmer. The authors would like to apologise for any inconvenience caused. Below is the correct order of authors: Claudio Bassi, MDa, Giovanni Marchegiani, MDa, Christos Dervenis, MD,b, Micheal Sarr, MDc, Mohammad Abu Hilal, MDd, Mustapha Adham, MDe, Peter Allen, MDf, Roland Andersson, MDg, Horacio J. Asbun, MDh, Marc G. Besselink, MDi, Kevin Conlon, MDj, Marco Del Chiaro, MDk, Massimo Falconi, MDl, Laureano Fernandez-Cruz, MDm, Carlos Fernandez-del Castillo, MDn, Abe Fingerhut, MDo, Helmut Friess, MDp, Dirk J Gouma, MDi, Thilo Hackert, MDq, Jakob Izbicki, MDr, Keith D. Lillemoe, MDn, John P. Neoptolemos, MDs, Attila Olah, MDt, Richard Schulick, MDu, Shailesh V. Shrikhande, MDv, Tadahiro Takada, MDw, Kyoichi Takaori, MDx, William Traverso, MDy, Charles Vollmer, MDz, Christopher L. Wolfgang, MDaa, Charles J. Yeo, MDbb, Roberto Salvia, MDa, Marcus Buchler, MDq, from the International Study Group on Pancreatic Surgery (ISGPS
Ultra-structure of the sperm head-to-tail linkage complex in the absence of the spermatid-specific LINC component SPAG4
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