165,159 research outputs found
Deutsche Schauspielerinnen / Emil Müller-Samswegen
No full textDEUTSCHE SCHAUSPIELERINNEN / EMIL MÜLLER-SAMSWEGEN
Deutsche Schauspielerinnen / Emil Müller-Samswegen (1)
Cover (1)
Chapter (3)
Deutsche Schauspielerinnen. (4
Müller glia activation in response to inherited retinal degeneration is highly varied and disease-specific
No full textDespite different aetiologies, most inherited retinal disorders culminate in photoreceptor loss, which induces concomitant changes in the neural retina, one of the most striking being reactive gliosis by Müller cells. It is typically assumed that photoreceptor loss leads to an upregulation of glial fibrilliary acidic protein (Gfap) and other intermediate filament proteins, together with other gliosis-related changes, including loss of integrity of the outer limiting membrane (OLM) and deposition of proteoglycans. However, this is based on a mix of both injury-induced and genetic causes of photoreceptor loss. There are very few longitudinal studies of gliosis in the retina and none comparing these changes across models over time. Here, we present a comprehensive spatiotemporal assessment of features of gliosis in the degenerating murine retina that involves Müller glia. Specifically, we assessed Gfap, vimentin and chondroitin sulphate proteoglycan (CSPG) levels and outer limiting membrane (OLM) integrity over time in four murine models of inherited photoreceptor degeneration that encompass a range of disease severities (Crb1rd8/rd8, Prph2+/Δ307, Rho-/-, Pde6brd1/rd1). These features underwent very different changes, depending upon the disease-causing mutation, and that these changes are not correlated with disease severity. Intermediate filament expression did indeed increase with disease progression in Crb1rd8/rd8 and Prph2+/Δ307, but decreased in the Prph2+/Δ307 and Pde6brd1/rd1 models. CSPG deposition usually, but not always, followed the trends in intermediate filament expression. The OLM adherens junctions underwent significant remodelling in all models, but with differences in the composition of the resulting junctions; in Rho-/- mice, the adherens junctions maintained the typical rod-Müller glia interactions, while in the Pde6brd1/rd1 model they formed predominantly between Müller cells in late stage of degeneration. Together, these results show that gliosis and its associated processes are variable and disease-dependent
Religionsbüchlein für Volksschulen in Städten und auf dem Lande ... / von F. G. N. Müller erstm. Prediger zu Obisfelde
No full textCoelum novum et terra nova : neu-eröffneter irrdische Himmel und himmlische Erden, das ist einfältige Kirchweyhungs-Predig, in dem hochansehentlichen, uhralt-erneüwerten, von dem hochwürdigen... Herrn Geroldo h. n. II.do zur Lauben ...zierlichistens neü-aufferbauenen den 12. Octobris Anno 1710 feyrlichistens neü-eingeweychten Tempels und Kirchen
No full textvorgetragen ... von r.p. Mauritio Müller ..
Nasuscoelum Santos & Mascarenhas & Müller 2023, n. gen.
No full textGenus: <i>Nasuscoelum</i> n. gen. Type- and only species: <i>Nasuscoelum pampensis</i> n. sp. Etymology: The genus name derives from the most parasitized site of infection (nasal cavity) <p>Figs. 1 & 2</p>Published as part of <i>Santos, José Junior Dos, Mascarenhas, Carolina Silveira & Müller, Gertrud, 2023, A new genus and new species of Cyclocoelidae (Digenea), a parasite in spotted rail, Pardirallus maculatus (Gruiformes: Rallidae), in the Pampa biome, southern Brazil, pp. 120-126 in Zootaxa 5319 (1)</i> on pages 121-122, DOI: 10.11646/zootaxa.5319.1.8, <a href="http://zenodo.org/record/8182254">http://zenodo.org/record/8182254</a>
Osmia (Hoplosmia) carbo Müller 2018, stat. nov.
No full textOsmia (Hoplosmia) carbo (Zanden 1994) stat. nov. Hoplosmia (Paranthocopa) pinguis carbo Zanden 1994: 1116. Type material: Holotype ♀, “ 8 km O Yeroham ” (Israel), private collection of M. Schwarz (Ansfelden). Literature records. EGYPT: Friese (1911). New records. SYRIA: Tadmur oasis, 9.4.1988 (leg. R. Kinzelbach). ISRAEL AND PALESTINE: Haifa District: Mt. Carmel, En Ayyala, 27.4.2000 (leg. M. Török); West Bank: Dead Sea N Qumeran Enot Zuqim Res., 6.6.1996 (leg. C. Schmid-Egger); Judean Desert, 7 km S Qumeran, 17.3.1997 (leg. J.G. Rozen, M.S. Engel); Yehuda plain, Geva'ot HaKhurkhar NP, 21.3.2011 (leg. A. Dorchin); Central District: Qadima, 24.2.2009 (leg. A. Dorchin); Rehovot, 7.3.2009 (leg. A. Dorchin); Netanya Iris Reserve, 4.4.2012 (leg. J.S. Ascher, A.Payne); Judean Foothills, Lakhish, 16.3.2013 (leg. T. Shapira); Tel Aviv District: Tel Aviv, 3– 10.4.1988 (leg. Guichard); Southern District: 10 km S Beersheva, 1.4.1988 (leg. Guichard); Arad, 6.4.1988 (leg. Guichard); Negev, 4 km SW Sede Boqer, 7.5.1997 (leg. J.G. Rozen); Arava Valley, Nahal Amazyahu, 30.3.2011 (leg. A. Dorchin); 7 km SE of Nitzana, 31.3.2012 (leg. J.S.Ascher, A.Payne); Negev Mt., Nahal Nizana, 15 km W Mizpe Ramon, 29.4.2013 (leg. A. Dorchin, D. Bénon, V. Trunz); JORDAN: 20 km S North Shuna, Tall Al Arbatin, 19.4.1996 (leg. M. Halada); 20 km N Madaba, 1.5.1999 (leg. W. Schläfle); Al Salt, Wadi Shu’ayb, 15.3.2001 (leg. S. Zaitoun); 10 km N Jerash, 20.4.2002 (leg. M. Snizek); Al-Shawbak, 18.4.2007 (leg. C. Praz, C. Sedivy, A. Müller); Wadi Mujib, King’s Highway, 19.4.2007 (leg. C. Praz, C. Sedivy, A. Müller); Wadi al Hasa S Al Karak, 20.4.2007 (leg. C. Praz, C. Sedivy, A. Müller). Distribution. Levant (Syria, Israel and Palestine, Jordan) and northern Egypt. Pollen hosts. Oligolectic on Asteraceae (based on 23 pollen loads from 15 different localities in Israel and Jordan and on field observations). The species exhibits a near exclusive preference for Cichorioideae and Asteroideae as pollen hosts: 17 pollen loads exclusively consisted of pollen of Cichorioideae (n = 11) or Asteroideae (n = 6), while six were mixed loads of pollen of both subfamilies. One load contained a substantial amount of pollen of Carduoideae beside pollen of Cichorioideae and Asteroideae, suggesting that Carduoideae are occasionally also exploited. Flower records: Andryala spec., Crepis aculeata, C. aspera, Anthemis spec., Chrysanthemum coronarium, Senecio vernalis (label records). Nesting biology. The nests are built in empty snail shells of small to medium size with a diameter of 13–25 mm (Mavromoustakis 1948; A. Müller unpublished data). Twenty-five nests from Jordan contained one (n = 2), two (n = 9) or three (n = 14) brood cells. The brood cells are separated from each other by one-layered partitions consisting of leaf pulp. An additional wall of leaf pulp seals the shell at or shortly behind its opening. Similar to O. spinulosa, the nests are not sealed against their rear end with a basal wall and the outermost cell partition is distinctly more robust than all the other cell partitions and the nest plug, probably acting as a barrier against parasites and predators. In contrast to O. spinulosa, the shells are never turned after they have been sealed. Note. Osmia carbo was treated by Zanden (1994) as a subspecies of O. pinguis Pérez 1895. As the distribution areas of the two taxa are widely separated and the morphological differences are substantial (see Fig. 11–15 and key to species), O. pinguis carbo is considered here to be a species of its own, i.e. O. carbo (Zanden 1994), stat. nov.Published as part of Müller, Andreas, 2018, Palaearctic Osmia bees of the subgenus Hoplosmia (Megachilidae, Osmiini): biology, taxonomy and key to species, pp. 297-329 in Zootaxa 4415 (2) on pages 301-303, DOI: 10.11646/zootaxa.4415.2.4, http://zenodo.org/record/124199
Reduced flavin : NMR investigation of N(5)-H exchange mechanism, estimation of ionisation constants and assessment of properties as biological catalyst
No full textBackground: The flavin in its FMN and FAD forms is a versatile cofactor that is involved in catalysis of most disparate types of biological reactions. These include redox reactions such as dehydrogenations, activation of dioxygen, electron transfer, bioluminescence, blue light reception, photobiochemistry (as in photolyases), redox signaling etc. Recently, hitherto unrecognized types of biological reactions have been uncovered that do not involve redox shuffles, and might involve the reduced form of the flavin as a catalyst. The present work addresses properties of reduced flavin relevant in this context. Results: N(5)-H exchange reactions of the flavin reduced form and its pH dependence were studied using the 15N-NMR-signals of 15N-enriched, reduced flavin in the pH range from 5 to 12. The chemical shifts of the N(3) and N(5) resonances are not affected to a relevant extent in this pH range. This contrasts with the multiplicity of the N(5)-resonance, which strongly depends on pH. It is a doublet between pH 8.45 and 10.25 that coalesces into a singlet at lower and higher pH values. From the line width of the 15N(5) signal the pH-dependent rate of hydrogen exchange was deduced. The multiplicity of the 15N(5) signal and the proton exchange rates are little dependent on the buffer system used. Conclusion: The exchange rates allow an estimation of the pKa value of N(5)-H deprotonation in reduced flavin to be ≥ 20. This value imposes specific constraints for mechanisms of flavoprotein catalysis based on this process. On the other hand the pK ≈ 4 for N(5)-H protonation (to form N(5)+-H2) would be consistent with a role of N(5)-H as a base
Ryhiner-Kartensammlung / 54/A Canton Lucern sive illustris helvetiorum respublica Lucernensis : cum subditis suis et confinibus
No full text[nach Gabriel Walser]Wahrscheinliches Ursprungswerk: "Schweizerischer Atlas bestehend in 19 Carten" (Schaffhausen : Johann Conrad Müller, um 1775) oder zweite Auflage (bei J.J. Mezger, um 1785)Nebenkarte unten rechts: "Die Herrschafft Griessenberg im Thurgeü dem Canton Lucern gehörig, samt den halben Gerichte[n] Hochikofen u. Hüseren" (6 x 7 cm)Titelkartusche oben rechts, Legende und Massstabsleiste unten MitteVerkleinerung der Karte von Gabriel Walser von 1763 (Nürnberg : Homannsche Erben
Aloys Müller, Einleitung in die Philosophie. 2e édit.
No full textKersten N. Aloys Müller, Einleitung in die Philosophie. 2e édit.. In: Revue néo-scolastique de philosophie. 35ᵉ année, Deuxième série, n°38, 1933. pp. 301-302
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