3,652 research outputs found
Ultra low density biodegradable shape memory polymer foams with tunable physical properties
No full textCompositions and/or structures of degradable shape memory polymers (SMPs) ranging in form from neat/unfoamed to ultra low density materials of down to 0.005 g/cc density. These materials show controllable degradation rate, actuation temperature and breadth of transitions along with high modulus and excellent shape memory behavior. A method of m ly low density foams (up to 0.005 g/cc) via use of combined chemical and physical aking extreme blowing agents, where the physical blowing agents may be a single compound or mixtures of two or more compounds, and other related methods, including of using multiple co-blowing agents of successively higher boiling points in order to achieve a large range of densities for a fixed net chemical composition. Methods of optimization of the physical properties of the foams such as porosity, cell size and distribution, cell openness etc. of these materials, to further expand their uses and improve their performance.U
The Brylinski beta function of a coaxial layer
Get PDFIn [Pooja Rani and M. K. Vemuri, The Brylinski beta function of a double layer, Differential Geom. Appl. \textbf{92}(2024)], an analogue of Brylinski\u27s knot beta function was defined for a compactly supported (Schwartz) distribution on Euclidean space. Here we consider the Brylinski beta function of the distribution defined by a coaxial layer on a submanifold of Euclidean space. We prove that it has an analytic continuation to the whole complex plane as a meromorphic function with only simple poles, and in the case of a coaxial layer on a space curves, we compute some of the residues in terms of the curvature and torsion
Powerful Teaching: Unleash the Science of Learning
No full textLibrarian, Judy Pinnolis, discusses Powerful Teaching: Unleash the Science of Learning by Dr. Pooja K. Agarwal, Assistant Professor at Berklee College of Music, and Patrice M. Bain.
Video editing by Stacey Snyder.https://remix.berklee.edu/library-books-at-berklee/1001/thumbnail.jp
Supplemental Material - Future thinking and anticipatory pleasure in adolescents with major depression: Association with depression symptoms and executive functions
No full textSupplemental Material for Future thinking and anticipatory pleasure in adolescents with major depression: Association with depression symptoms and executive functions by Pooja M Lakshmi, M Thomas Kishore, Roopesh B N, Preeti Jacob, Danielle Rusanov, and David J Hallford in Clinical Child Psychology and Psychiatry</p
PoojaMiddha/GeRI_colitis: Polygenic risk score for ulcerative colitis predicts immune checkpoint inhibitor-mediated colitis
No full text<p>This repository provides code for developing and validating a polygenic risk score for ulcerative colitis and Crohn's disease and evaluating the role of the polygenic risk score on immune checkpoint inhibitor-mediated colitis, as described in:</p>
<p><strong>Polygenic risk score for ulcerative colitis predicts immune checkpoint inhibitor-mediated colitis</strong></p>
<p>Pooja Middha, Rohit Thummalapalli, Michael J. Betti, Lydia Yao, Zoe Quandt, Karmugi Balaratnam, Cosmin A. Bejan, Eduardo Cardenas, Christina J. Falcon, David M. Faleck, Princess Margaret Lung Group, Matthew A. Gubens, Scott Huntsman, Douglas B. Johnson, Linda Kachuri, Khaleeq Khan, Min Li, Christine M. Lovly, Megan H. Murray, Devalben Patel, Kristin Werking, Yaomin Xu, Luna Jia Zhan, Justin M. Balko, Geoffrey Liu, Melinda C. Aldrich, Adam J. Schoenfeld, Elad Ziv</p>
<p>medRxiv 2023.05.15.23289680; doi: https://www.medrxiv.org/content/10.1101/2023.05.15.23289680v2</p>
Surface Modification Of Polymer Foams Using Plasma
No full textAn embodiment includes a system comprising: a monolithic shape memory polymer (SMP) foam having first and second states; wherein the SMP foam includes: (a) polyurethane, (b) an inner half portion having inner reticulated cells defined by inner struts, (c) an outer half portion, having outer reticulated cells defined by outer struts, surrounding the inner portion in a plane that provides a cross-section of the SMP foam, (d) hydroxyl groups chemically bound to outer surfaces of both the inner and outer struts. Other embodiments are discussed herein.U
Shape memory polymer nonocomposites and uses thereof
No full textThe invention relates to radiopaque shape memory foam compositions and methods of using the compositions. In certain embodiments, the compositions are used in neurovascular occlusion applications.U
Device and method for treatment of openings in vascular and septal walls
No full textA device, system and method for treatment of an opening in vascular and/or septal walls including patent foramen ovale. The device has wings/stops on either end, an axis core covered in a shape memory foam and is deliverable via a catheter to the affected opening, finally expanding into a vascular or septal opening where it is held in place by the expandable shape memory stops or wings.U
Design, Synthesis And Evaluation Of Novel Antimycobacterial Compounds Targeting The MmpL3 Transporter Protein.
No full textTuberculosis (TB) is an airborne infectious disease caused by Mycobacterium tuberculosis (M. tb). TB is one of the leading causes of death in developing countries. Current TB therapy requires a minimum six-month treatment and is associated with increasing drug resistance and decreased patient compliance. Therefore, new anti-TB compounds with novel mechanisms of action that have activity against resistant strains and can potentially reduce treatment duration are urgently needed. Mycolic acids are the primary lipid components in the mycobacterial cell wall and are responsible for mycobacterial cell wall integrity, permeability and virulence. Mycobacterial membrane protein large 3 (MmpL3) is an essential transporter responsible for the translocation of mycolic acids to the outer membrane. Published indole-2-carboxamides with suggested MmpL3 inhibition showed good potency, against whole-cell M. tb, yet had poor aqueous solubility. This project hypothesizes that bioisosteric replacement of the indole ring, will maintain anti-tubercular activity with improved aqueous solubility leading to enhanced pharmacokinetics. The project focuses on retaining the required pharmacophore and increasing the molecular heteroatom percentage by reducing lipophilic atoms. The designed and synthesized indole bioisosteres are pyrrole, mandelic acid and imidazole, coupled to lipophilic head groups ensuring anti-tubercular activity. In addition to minimum inhibitory concentration (MIC) determination, the active compounds were subjected to in vitro ADMET assays, including aqueous solubility, permeability and metabolic stability toward mouse liver S9 fractions, to determine their suitability for further in vivo preclinical evaluation.|Lead compounds had improved pharmacokinetics over their indole-2-carboxamide analogs while their potency against mycobacteria varied. It was observed that an improvement in the aqueous solubility negatively impacted the anti-tubercular potency. Pyrrole analogs were found to be the best with respect to activity and had an improved solubility, permeability and were metabolically stable.ProQuest Traditional Publishing Optio
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