4,178 research outputs found
Pharmacoeconomic analysis of adjuvant oral capecitabine vs intravenous 5-FU/LV in Dukes' C colon cancer: the X-ACT trial
No full textOral capecitabine (Xeloda<sup>®</sup>) is an effective drug with favourable safety in adjuvant and metastatic colorectal cancer. Oxaliplatin-based therapy is becoming standard for Dukes' C colon cancer in patients suitable for combination therapy, but is not yet approved by the UK National Institute for Health and Clinical Excellence (NICE) in the adjuvant setting. Adjuvant capecitabine is at least as effective as 5-fluorouracil/leucovorin (5-FU/LV), with significant superiority in relapse-free survival and a trend towards improved disease-free and overall survival. We assessed the cost-effectiveness of adjuvant capecitabine from payer (UK National Health Service (NHS)) and societal perspectives. We used clinical trial data and published sources to estimate incremental direct and societal costs and gains in quality-adjusted life months (QALMs). Acquisition costs were higher for capecitabine than 5-FU/LV, but higher 5-FU/LV administration costs resulted in 57% lower chemotherapy costs for capecitabine. Capecitabine vs 5-FU/LV-associated adverse events required fewer medications and hospitalisations (cost savings £3653). Societal costs, including patient travel/time costs, were reduced by >75% with capecitabine vs 5-FU/LV (cost savings £1318), with lifetime gain in QALMs of 9 months. Medical resource utilisation is significantly decreased with capecitabine vs 5-FU/LV, with cost savings to the NHS and society. Capecitabine is also projected to increase life expectancy vs 5-FU/LV. Cost savings and better outcomes make capecitabine a preferred adjuvant therapy for Dukes' C colon cancer. This pharmacoeconomic analysis strongly supports replacing 5-FU/LV with capecitabine in the adjuvant treatment of colon cancer in the UK
Chosen logistics processes in Škoda JS
No full textThis master thesis deals with the purchase and sale process in Škoda JS company. The aim of this work is to assess whether the setting of the purchase and sale process is met by the company also within a real business case, in compliance with set controls, and whether the degree of perfect delivery is sufficient. In the introduction, the author specifies the basic terms: logistics, logistic chain, customer benefits, information systems in logistics, buying and selling. The following chapter introduces Škoda JS company, including the sphere of its entrepreneurial activity. This chapter also deals with the nuclear power industry. In the crucial chapter, the author describes the process of purchase and sale in Škoda JS company and compares it with a real business case. In conclusion, the author evaluates discrepancies and suggests recommendations to avoid them
Normal reference values for left atrial strain and its determinants from a large Korean multicenter registry
No full textBACKGROUND: Left atrial (LA) strain is a novel parameter of LA function. However, its reference value has not been established, and the determining factors for LA strain remain elusive. We aimed to present LA strain with reservoir, conduit, and contractile components and associated parameters in a large-sized group of healthy individuals. METHODS: The present study was from a prospective multicenter registry in South Korea. Subjects who had no history of cardiovascular disease with adequate images were eligible for inclusion. LA reservoir, conduit, and contractile strains (LASRES, LASCD and LASCT, respectively) were measured. Left ventricular global longitudinal strain (LV GLS) and early and late diastolic strain rates (DSRe and DSRa, respectively) were also evaluated. RESULTS: Among a total of 324 subjects (mean age: 49 ± 16 years, 167 females), the mean LASRES, LASCD, and LASCT values were 35.9% ± 10.6%, 21.9% ± 9.3%, and 13.9% ± 3.6%, respectively. Mean LV GLS was-20.4% ± 2.2%, and mean DSRe and DSRa were 1.6 ± 0.4 s-1 and 0.8 ± 0.3 s-1, respectively. With aging, LASRES and LASCD showed significant decreases. Factors showing independent associations with LASRES were age (B =-0.425, p < 0.001), DSRe (B = 4.706, p = 0.001), and LV GLS (B =-1.081, p < 0.001). Age (B =-0.319, p < 0.001), DSRe (B = 4.140, p = 0.002), DSRa (B =-3.409, p = 0.018), and LV GLS (B =-0.783, p < 0.001) showed associations with LASCD. With LASCT, only DSRa showed a correlation (R = 0.277, p < 0.001). CONCLUSIONS: We presented LA strain in a large-sized group of healthy subjects. Age is a significant determinant of LA function. Associations of LA strain with diastolic strain rates and LV GLS reflect cardiac mechanics. © 2020 Korean Society of Echocardiography
The effect of augmented feedback type and frequency on velocity-based training-induced adaptation and retention
No full textThe purpose of this study was to compare the benefits of 4-weeks of velocity-based training (VBT) using different augmented feedback (AugFb) types and the frequency of AugFb, and whether adaptations are retained 10 days post-training. Thirty-seven collegiate male rugby players were divided into groups that received immediate-feedback (ImFb; n=9), visual-feedback (ViFb; n=10), average-feedback (AvgFb; n=10) and no-feedback (NoFb; n=8) during each VBT session consisting of 3 sets of 5 repetitions of loaded jump squats. The ImFb group received AugFb regarding lifting velocity under loaded jump squats (LV-JS) following every jump, whereas LV-JS measures were averaged following each set of jumps and presented to the AvgFb group. The loaded jump squats were video-recorded and displayed as kinematic feedback for the ViFb group following each set, although no feedback was provided for the NoFb group. LV-JS measures were reported at baseline, during each training session and 10-days post training. LV-JS measures were significantly greater for the ImFb Group compared to the other groups during a number of post-baseline time points (P<0.05). Furthermore, at 4-weeks of VBT and 10 days post-retention, effect size (ES) calculations showed that LV-JS measures were greater with moderate to large effects for the ImFb group compared to the NoFb (ES=1.02-1.25), AvgFb (ES=0.78-0.82) and ViFb (ES=0.74-1.60), respectively. However, LV-JS measures were reduced with moderate to large effects 10 days post-retention for the ViFb (ES=-0.60) and NoFb (ES=-0.85) groups. Providing LV-JS feedback following each jump appears to optimize performance and should be considered as a training tool during VBT
Clinical utility of early postoperative cardiac multidetector computed tomography after coronary artery bypass grafting
No full textWe evaluated the clinical utility of early postoperative cardiac computed tomography (CT) for evaluating left ventricular (LV) function and predicting prognosis in patients who had undergone coronary artery bypass grafting (CABG). Of the 205 patients who underwent CABG from March 2011 to December 2014, 136 underwent early postoperative cardiac CT (within 30 days after CABG) and were enrolled as the study population. The baseline and postoperative follow-up echocardiographic findings, major adverse cardiac events (MACE), and death were recorded for a follow-up period (mean, 5.9 +/- 1.1 years). Functional cardiac CT parameters were compared to echocardiographic measurements. The associations between cardiac CT findings and functional recovery and prognosis were evaluated by logistic regression analyses. The LVEF measured via cardiac CT was significantly higher (56.2 +/- 11.5% vs. 61.9 +/- 12.9%; p = 0.0002) compared to those via early postoperative echocardiography, but the wall motion score index (WMSI) was not significantly different (1.23 +/- 0.33 vs. 1.21 +/- 0.28, p = 0.5041) between the two methods. During the follow-up period, 17 patients (12.5%) died and 40 (29.4%) developed MACE. Both the LVEF and WMSI measured with early postoperative echocardiography (p = 0.0202 and odds ratio [OR] = 5.0171, p = 0.0039, respectively), and cardiac CT (OR = 0.9625, p = 0.0091 and OR = 14.3605, p = 0.0001, respectively) predicted MACE OR = 0.9630, but only the WMSI, measured using cardiac CT, predicted all-cause death (OR = 10.6017, p = 0.0035). In CABG patients, LVEF and the WMSI measured with early postoperative cardiac CT were comparable with echocardiography and predicted the development of MACE and all-cause death
Comparison of Javascript ES6 and its React JS library from the point of view of a beginning developer
No full textThis bachelor thesis deals with the issue of Vanilla JavaScript and its React JS library from the perspective of a beginning developer. The aim of the work is to map in detail, practically demonstrate and then compare the basic principles of selected tools Vanilla JavaScript and React JS. The work consists of three imaginary parts. After defining important terms, the author deals in the first part with the Vanilla JavaScript approach. The given part of the procedure presents important principles of pure JavaScript with the end of the part, which is an example of practical development in this tool. The second part of the work deals with the React JS library in the same way. The given part of the work goes again from the description of theoretical principles to a practical demonstration of the development of a functionally identical application, but this time from the point of view of the React JS tool. In the third and final part of the work, the author theoretically compares the key differences, advantages and disadvantages of the principles in the development of the application in Vanilla JavaScript and the React JS library. This part is then concluded with a final summary of the comparison with a detailed description of the advantages and disadvantages of each approach with a framework recommendation for the use of the solutions in various development situations. After reading the work, the reader should get a comprehensive idea of the possibilities of using the tools in solving specific problems, in such a way that they can choose the right tool in practice to solve the problem.Táto bakalárska práca sa zaoberá problematikou Vanilla JavaScriptu a jeho knižnice React JS z pohľadu začínajúceho vývojára. Cieľom práce je detailne zmapovať, prakticky demonštrovať a následne porovnať základné princípy vybraných nástrojov Vanilla JavaScript a React JS. Práca sa skladá z troch pomyselných častí. Po vymedzení dôležitých pojmov sa autor v prvej časti venuje prístupu Vanilla JavaScriptu. Daná časť postupe predstavuje dôležité princípy čistého JavaScriptu so zakončením časti, ktorá tvorí ukážka praktického vývoja v tomto nástroji. Druhá časť práce sa rovnakým spôsobom venuje knižnici React JS. Daná časť práce prechádza opäť od popisu teoretických princípov až po praktickú ukážku vývoja funkcionálne rovnakej aplikácie, tentokrát však z pohľadu nástroja React JS. V tretej a zároveň záverečnej časti práce autor teoreticky porovnáva kľúčové rozdiely, výhody a nevýhody daných princípov pri vývoji aplikácie vo Vanilla JavaScripte a knižnici React JS. Táto časť je následne ukončená záverečným zhrnutím porovnania s detailným popisom výhod a nevýhod jednotlivých prístupov s rámcovým odporúčaním použitia daných riešení v rôznych situáciách vývoja. Po prečítaní danej práce by mal čitateľ získať komplexnú predstavu o možnostiach využitia daných nástrojov pri riešení konkrétnych problémov, takým spôsobom, aby si pri riešení problému v praxi vedel vybrať ten správny nástroj.Tato bakalářská práce se zabývá problematikou Vanilla JavaScriptu a jeho knihovny React JS z pohledu začínajícího vývojáře. Cílem práce je detailně zmapovat, prakticky demonstrovat a následně porovnat základní principy vybraných nástrojů Vanilla JavaScript a React JS. Práce se skládá ze tří pomyslných částí. Po vymezení důležitých pojmů se autor v první části věnuje přístupu Vanilla JavaScriptu. Daná část postupu představuje důležité principy čistého JavaScriptu se zakončením části, která tvoří ukázka praktického vývoje v tomto nástroji. Druhá část práce se stejným způsobem věnuje knihovně React JS. Daná část práce přechází opět od popisu teoretických principů až po praktickou ukázku vývoje funkcionální stejné aplikace, tentokrát však z pohledu funkce React JS. Ve třetí a zároveň závěrečné části práce autor teoreticky porovnává klíčové rozdíly, výhody a nevýhody daných principů při vývoji aplikace ve Vanilla JavaScriptu a knihovně React JS. Tato část je následně ukončena závěrečným shrnutím srovnání s detailním popisem výhod a nevýhod jednotlivých přístupů s rámcovým doporučením použití daných řešení v různých situacích vývoje. Po přečtení dané práce by měl čtenář získat komplexní představu o možnostech využití daných nástrojů při řešení konkrétních problémů, takovým způsobem, aby si při řešení problému v praxi věděl vybrat ten správný nástroj
Comparison of Javascript ES6 and its React JS library from the point of view of a beginning developer
No full textThis bachelor thesis deals with the issue of Vanilla JavaScript and its React JS library from the perspective of a beginning developer. The aim of the work is to map in detail, practically demonstrate and then compare the basic principles of selected tools Vanilla JavaScript and React JS. The work consists of three imaginary parts. After defining important terms, the author deals in the first part with the Vanilla JavaScript approach. The given part of the procedure presents important principles of pure JavaScript with the end of the part, which is an example of practical development in this tool. The second part of the work deals with the React JS library in the same way. The given part of the work goes again from the description of theoretical principles to a practical demonstration of the development of a functionally identical application, but this time from the point of view of the React JS tool. In the third and final part of the work, the author theoretically compares the key differences, advantages and disadvantages of the principles in the development of the application in Vanilla JavaScript and the React JS library. This part is then concluded with a final summary of the comparison with a detailed description of the advantages and disadvantages of each approach with a framework recommendation for the use of the solutions in various development situations. After reading the work, the reader should get a comprehensive idea of the possibilities of using the tools in solving specific problems, in such a way that they can choose the right tool in practice to solve the problem.Táto bakalárska práca sa zaoberá problematikou Vanilla JavaScriptu a jeho knižnice React JS z pohľadu začínajúceho vývojára. Cieľom práce je detailne zmapovať, prakticky demonštrovať a následne porovnať základné princípy vybraných nástrojov Vanilla JavaScript a React JS. Práca sa skladá z troch pomyselných častí. Po vymedzení dôležitých pojmov sa autor v prvej časti venuje prístupu Vanilla JavaScriptu. Daná časť postupe predstavuje dôležité princípy čistého JavaScriptu so zakončením časti, ktorá tvorí ukážka praktického vývoja v tomto nástroji. Druhá časť práce sa rovnakým spôsobom venuje knižnici React JS. Daná časť práce prechádza opäť od popisu teoretických princípov až po praktickú ukážku vývoja funkcionálne rovnakej aplikácie, tentokrát však z pohľadu nástroja React JS. V tretej a zároveň záverečnej časti práce autor teoreticky porovnáva kľúčové rozdiely, výhody a nevýhody daných princípov pri vývoji aplikácie vo Vanilla JavaScripte a knižnici React JS. Táto časť je následne ukončená záverečným zhrnutím porovnania s detailným popisom výhod a nevýhod jednotlivých prístupov s rámcovým odporúčaním použitia daných riešení v rôznych situáciách vývoja. Po prečítaní danej práce by mal čitateľ získať komplexnú predstavu o možnostiach využitia daných nástrojov pri riešení konkrétnych problémov, takým spôsobom, aby si pri riešení problému v praxi vedel vybrať ten správny nástroj.Tato bakalářská práce se zabývá problematikou Vanilla JavaScriptu a jeho knihovny React JS z pohledu začínajícího vývojáře. Cílem práce je detailně zmapovat, prakticky demonstrovat a následně porovnat základní principy vybraných nástrojů Vanilla JavaScript a React JS. Práce se skládá ze tří pomyslných částí. Po vymezení důležitých pojmů se autor v první části věnuje přístupu Vanilla JavaScriptu. Daná část postupu představuje důležité principy čistého JavaScriptu se zakončením části, která tvoří ukázka praktického vývoje v tomto nástroji. Druhá část práce se stejným způsobem věnuje knihovně React JS. Daná část práce přechází opět od popisu teoretických principů až po praktickou ukázku vývoje funkcionální stejné aplikace, tentokrát však z pohledu funkce React JS. Ve třetí a zároveň závěrečné části práce autor teoreticky porovnává klíčové rozdíly, výhody a nevýhody daných principů při vývoji aplikace ve Vanilla JavaScriptu a knihovně React JS. Tato část je následně ukončena závěrečným shrnutím srovnání s detailním popisem výhod a nevýhod jednotlivých přístupů s rámcovým doporučením použití daných řešení v různých situacích vývoje. Po přečtení dané práce by měl čtenář získat komplexní představu o možnostech využití daných nástrojů při řešení konkrétních problémů, takovým způsobem, aby si při řešení problému v praxi věděl vybrat ten správný nástroj
3D pgRouting and visualization in Cesium JS using the integrated model of LADM and IndoorGML
No full textA web-based application has been developed, exploiting the integrated model of LADM andIndoorGML to provide indoor navigation based on the user's access rights in an educationalbuilding. Different types of users (students, teachers, visitors, etc.) have different access rights,which also depend on the exact time (e.g. inside or outside office hours). A 3D BIM IFC fileof a building has been geo-referenced and converted into a LADM complaint database inPostgreSQL/PostGIS and is enriched with information about access rights based on therelationship between users, time and indoor spaces. The PostgreSQL extension pgRouting hasbeen used for the actual routing. To support the access rights-based routing, the databasecontains several tables to represent nodes, edges, parties (users), and rights. There is one overallnetwork for the whole building, and database views are used to dynamically select the relevantnodes and edges based on the time and the user’s rights. The Dijkstra algorithm is used tocompute the shortest path. Finally, the 3D geospatial web-platform Cesium JS is used to createa client GUI allowing to specify start and destination, the user and time, and to visualize thenavigation routes. As this GUI is web-based it can run on different platforms, such as desktops,laptops, tablets and mobile phones. This paper provides a complete description of all the stepsto design, develop and test the integrated model of LADM and IndoorGML.GIS Technologi
Meir-Keeler Type Contractions on Js-Metric Spaces and Related Fixed Point Theorems
No full textKARAPINAR, ERDAL/0000-0002-6798-3254We introduce two classes of Meir-Keeler type contractions in the framework of JS-metric spaces introduced by Jleli and Samet (2015). For each class, a fixed point result is derived. Some interesting consequences which follow from our obtained results are discussed.King Saud University (Saudi Arabia)The second author extends his appreciation to Distinguished Scientist Fellowship Program (DSFP) at King Saud University (Saudi Arabia)
Eddy-Induced Growth Rate of Low-Frequency Variability and Its Mid- to Late Winter Suppression in the Northern Hemisphere
No full textSynoptic eddy and low-frequency flow (SELF) feedback plays an important role in reinforcing low-frequency variability (LFV). Recent studies showed that an eddy-induced growth (EIG) or instability makes a fundamental contribution to the maintenance of LFV. To quantify the efficiency of the SELF feedback, this study examines the spatiotemporal features of the empirical diagnostics of EIG and its associations with LFV. The results show that, in terms of eddy vorticity forcing, the EIG rate of LFV is generally larger (smaller) in the upper (lower) troposphere, whereas, in terms of eddy potential vorticity forcing, it is larger in the lower troposphere to partly balance the damping effect of surface friction. The local EIG rate shows a horizontal spatial distribution that corresponds to storm-track activity, which tends to be responsible for maintaining LFV amplitudes and patterns as well as sustaining eddy-driven jets. In fact, the EIG rate has a well-defined seasonality, being generally larger in cold seasons and smaller in the warmest season, and this seasonality is stronger in the Northern Hemisphere than in the Southern Hemisphere. This study also reveals a mid-to late winter (January-March) suppression of the EIG rate in the Northern Hemisphere, which indicates a reduced eddy feedback efficiency and may be largely attributed to the eddy kinetic energy suppression and the midlatitude zonal wind maximum in the midwinter of the Northern Hemisphere.O (subject to Restrictions below, author can archive publisher's version/PDF)1144sciescopu
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