1,721,052 research outputs found
Extended spectrum beta lactamase and carbapenemase determinants in clinically relevant enterobacteria and nonfermenting Gram-negative rods.
No full textFaramacoresistenza dei patogeni Gram-negativi. Basi genetiche, biochimiche, epidemiologia, implicazioni clinich
Batteri Gram-negativi produttori di beta-lattamasi a spettro esteso (ESBL): epidemiologia, diagnosi e implicazioni terapeutiche.
No full textBiologia e clinica degli enzimi che idorlizzano i beta-lattamici. Epidemiologia e infezioni ospedalire. Farmacoresistenza
Bacteremia due to multidrug-resistant Pseudomonas aeruginosa. relation of drug resistance with pathogenesis-related genes
No full textDiagnostica delle ß-lattamasi a spettro esteso (ESBL) nelle Enterobacteriaceae: problemi e raccomandazioni nella realtà epidemiologica italiana
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Outbreack of Extended-spectrum beta-lactamase producing Serratia marcescens in an intensive care unit
No full textDissemination of CTX-M-type extended-spectrum β-lactamase genes to unusual hosts
No full textA Citrobacter amalonaticus and a Morganella morganii producing the CTX-M-1 extended-spectrum β-lactamase (ESBL) were isolated from an area where this enzyme is now widespread in Escherichia coli. This is the first report of CTX-M-1 in the former species. In both cases the ESBL determinant was possibly acquired by these unusual hosts in vivo, after coinfection with E. coli strains carrying conjugative plasmids encoding CTX-M-1. Copyright © 2005, American Society for Microbiology. All Rights Reserved
Multidrug-resistant Pseudomonas aeruginosa producing PER-1 extended-spectrum serine-β-lactamase and VIM-2 metallo-β-lactamase [2]
No full textPER-1 extended-spectrum β-lactamase production in an Alcaligenes faecalis clinical isolate resistant to expanded-spectrum cephalosporins and monobactams from a hospital in Northern Italy
No full textAn Alicaligenes faecalis (FL-424/98) resistant to expanded-spectrum cephalosporins and aztreonam was isolated from the urine of an inpatient at the Intensive Care Unit of the Varese Hospital (Northern Italy) after antimicrobial chemotherapy with cefazolin, vancomycin, and amikacin. Clavulanic acid restored the activity of expanded-spectrum cephalosporins, suggesting the production of an extended-spectrum β-lactamase (ESβL). A crude extract of FL-424/98 showed the presence of two β-lactamase activities focusing at pH 5.3 and 7.6, respectively. The ESβL activity, purified by means of three chromatographic steps, was found to correspond to the pI 5.3 enzyme. Determination of kinetic parameters confirmed that the enzyme efficiently hydrolyzed expanded-spectrum cephalosporins and aztreonam. A colony-blot hybridization revealed the presence of bla(PER)-related sequences in FL-424/98, and sequencing confirmed the identity of this determinant with bla(PER-1), previously detected in Pseudomonas aeruginosa, Acinetobacter, and Salmonella clinical isolates from Turkey. Finding of bla(PER-1) in a species that can be part of the resident human microbiota raises the possibility that it could be an efficient shuttle for spreading of this resistance gene among other opportunistic pathogens that are normally members of the resident microbiota. Kinetic parameters determined for the PER-1 enzyme with some cephalosporin substrates were somewhat different from those previously reported
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