1,358 research outputs found
Long COVID — long-term health outcomes, and implications for policy and research
No full textLong COVID, which refers to post-acute and chronic sequelae of SARS-CoV-2 infection, can affect nearly every organ system and all demographic groups. The high and growing toll of long COVID calls for an urgent need to understand how to prevent and treat it. Governments and health systems must address the care needs of people with long COVID
Interview with YA mystery author, Valerie Sherrard
No full textAn interview with Valerie Sherrard, a YA author, which focuses on her process of writing the Shelby Belgarden mystery series.
Granulomatous interstitial nephritis in a patient with SARS-CoV-2 infection
Full text linkBackground
Acute kidney injury (AKI) associated with severe coronavirus disease 19 (COVID-19) is common and is a significant predictor of morbidity and mortality, especially when dialysis is required. Case reports and autopsy series have revealed that most patients with COVID-19 – associated acute kidney injury have evidence of acute tubular injury and necrosis - not unexpected in critically ill patients. Others have been found to have collapsing glomerulopathy, thrombotic microangiopathy and diverse underlying kidney diseases. A primary kidney pathology related to COVID-19 has not yet emerged. Thus far direct infection of the kidney, or its impact on clinical disease remains controversial. The management of AKI is currently supportive.
Case Presentation
The patient presented here was positive for SARS-CoV-2, had severe acute respiratory distress syndrome and multi-organ failure. Within days of admission to the intensive care unit he developed oliguric acute kidney failure requiring dialysis. Acute kidney injury developed in the setting of hemodynamic instability, sepsis and a maculopapular rash. Over the ensuing days the patient also developed transfusion-requiring severe hemolysis which was Coombs negative. Schistocytes were present on the peripheral smear. Given the broad differential diagnoses for acute kidney injury, a kidney biopsy was performed and revealed granulomatous tubulo-interstitial nephritis with some acute tubular injury. Based on the biopsy findings, a decision was taken to adjust medications and initiate corticosteroids for presumed medication-induced interstitial nephritis, hemolysis and maculo-papular rash. The kidney function and hemolysis improved over the subsequent days and the patient was discharged to a rehabilitation facility, no-longer required dialysis.
Conclusions
Acute kidney injury in patients with severe COVID-19 may have multiple causes. We present the first case of granulomatous interstitial nephritis in a patient with COVID-19. Drug-reactions may be more frequent than currently recognized in COVID-19 and are potentially reversible. The kidney biopsy findings in this case led to a change in therapy, which was associated with subsequent patient improvement. Kidney biopsy may therefore have significant value in pulling together a clinical diagnosis, and may impact outcome if a treatable cause is identified
Fashion Culture: Misty Copeland in conversation with Valerie Steele
No full textMisty Copeland is a soloist with American Ballet Theatre. In 2007 she made history by becoming their second African American Female Soloist and the first in two decades. In September 2014, she was the first black woman to perform the lead role of Odette/Odile in American Ballet Theatre’s production of Swan Lake during the company’s first ever tour to Australia. Misty is the author of the New York Times bestselling memoir, Life in Motion (2014), co-written with Charisse Jones, and of the picture book Firebird (2014) in collaboration with Christopher Myers.Misty Copeland was in conversation with Valerie Steele at The Museum at FIT on Tuesday, November 4, 2014
Pink Symposium: Dr. Valerie Steele “Pink: The History of a Color”
No full textThe Museum at FIT presented Pink, its twentieth academic symposium. This symposium explored the significance of the color pink in fashion, art, and culture. Pink provokes exceptionally strong feelings of both attraction and repulsion, yet it is increasingly being regarded as cool and androgynous, powerful and political. Topics included the significance of pink clothing in western and non-western cultures (including India, Africa, Mexico, and Japan), the role of pink in eighteenth-century portraiture, associations of pink with politics, gender, and sexuality, and the use of pink in cinema.Dr. Valerie Steele is director and chief curator of MFIT. Her current exhibition is Pink: The History of a Punk, Pretty, Powerful Color. She is the author or editor of numerous books, including Pink and Paris Fashion: A Cultural History
Fighting the unbearable lightness of neglecting kidney health:the decade of the kidney
Full text linkA brief comprehensive overview is provided of the elements constituting the burden of kidney disease [chronic kidney disease (CKD) and acute kidney injury]. This publication can be used for advocacy, emphasizing the importance and urgency of reducing this heavy and rapidly growing burden. Kidney diseases contribute to significant physical limitations, loss of quality of life, emotional and cognitive disorders, social isolation and premature death. CKD affects close to 100 million Europeans, with 300 million being at risk, and is projected to become the fifth cause of worldwide death by 2040. Kidney disease also imposes financial burdens, given the costs of accessing healthcare and inability to work. The extrapolated annual cost of all CKD is at least as high as that for cancer or diabetes. In addition, dialysis treatment of kidney diseases imposes environmental burdens by necessitating high energy and water consumption and producing plastic waste. Acute kidney injury is associated with further increases in global morbidity, mortality and economic burden. Yet investment in research for treatment of kidney disease lags behind that of other diseases. This publication is a call for European investment in research for kidney health. The innovations generated should mirror the successful European Union actions against cancer over the last 30 years. It is also a plea to nephrology professionals, patients and their families, caregivers and kidney health advocacy organizations to draw, during the Decade of the Kidney (2020-30), the attention of authorities to realize changes in understanding, research and treatment of kidney disease.</p
Fetal and child health - impact on kidney development and long-term risk of hypertension and kidney disease
Full text linkDevelopmental programming of non-communicable diseases is now an established paradigm. With respect to hypertension and chronic kidney disease, adverse events experienced in utero can affect development of the fetal kidney and reduce final nephron number. Low birthweight and prematurity are the most consistent clinical surrogates for a low nephron number and are associated with increased risk of hypertension, proteinuria, and kidney disease in later life. Rapid weight gain in childhood or adolescence further compounds these risks. Low birthweight, prematurity, and rapid childhood weight gain should alert clinicians to an individual's lifelong risk of hypertension and kidney disease, prompting education to minimise additional risk factors and ensuring follow-up. Birthweight and prematurity are affected substantially by maternal nutrition and health during pregnancy. Optimisation of maternal health and early childhood nutrition could, therefore, attenuate this programming cycle and reduce the global burden of hypertension and kidney disease in the future.This is the fourth in a Series of six papers about global kidney disease<br/
Maynard Jackson, Valerie, and Their Children, 1988
No full textMayor Jackson with his family. Front row: Maynard III "Buzzy" and Brooke. Back Row: Valerie-Amanda, Valerie, Maynard Jr., Elizabeth, and Alexandra
The legacy of church-run mother and baby homes in Ireland
No full textThis article is based on an interview with Dr. Valerie O’Brien, lecturer and researcher in Applied Social Science at University College Dublin, about her joint project with Dr. Joyce Maguire Pavao, founder and CEO of Center For Family Connections in Boston and lecturer in Psychiatry at Harvard Medical School. The aim is to reach out to those involved in the adoption of children from Ireland to USA and to record a history obscured by Church and State. By sharing these stories, O’Brien and Maguire Pavao see an opportunity to positively affect modern adoption practices in Ireland as well as bring dignity to the mothers who were forgotten by their community.Not applicableJG suggests that we change the editor Aliah O'Neil to author and record Valerie O'Brien as DC contributor or DC contributor.other, not the author. Also keep the link to html page as the file download - AV 19/7/201
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