323,084 research outputs found

    Flexible Measures in Magnetic Active Shielding

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    Browse Conference Publications > Electromagnetic Field Computa ... Flexible measures in magnetic Active Shielding .This paper appears in: Electromagnetic Field Computation (CEFC), 2010 14th Biennial IEEE Conference on Date of Conference: 9-12 May 2010 Author(s): Formisano, A. Dip. Ing. dell'Inf., Seconda Univ. di Napoli, Aversa, Italy Lupoli, M.C. ; Martone, R. Page(s): 1 Product Type: Conference Publications 5481633 searchabstract .Abstract The reduction in protected regions of low frequency magnetic fields is a complex problem when the sources are not known. The paper proposes a procedure able to choose the best currents able to mitigate the disturbance field. The magnetic field is represented by suitable series of eigenfunctions in the domain of interest. The procedure includes a field identification step starting from a set of measurements and a current design step, possibly based on a preliminary design of specialized shimming coils sets

    Dietary Salt Intake, Blood Pressure, and Genes

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    Our ancestors developed in environments characterized by salt scarcity; their salt intake was less than 1 g/day and efficient physiological mechanisms were evolved to retain salt. Nowadays, in many countries in the world, the current dietary salt intake is very high (10 g/day on average) and largely exceeds the recommended 5 g/day. Although not all studies agree, many evidences point to a relationship between high salt consumption, blood pressure, and its associated cardiovascular risk. Therefore, the adoption of a salt intake reduction is justified. Salt sensitivity, defined as blood pressure response to salt intake, is heterogeneous among subjects. Many authors have investigated the genetic bases of salt sensitivity, mainly with a candidate gene approach. Most of these findings need replication and much work is still necessary to identify the true genetic risk factors

    Pharmacogenomics considerations in the control of hypertension

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    The response to antihypertensive therapy is very heterogeneous and the need by the physicians to account for it has driven much interest in pharmacogenomics of antihypertensive drugs. The Human Genome Project and the initiatives in genomics that followed, generated a huge number of genetic data that furnished the tools to explore the genotype-phenotype association in candidate genes and at genome-wide level. In spite of the efforts and the great number of publications, pharmacogenomics of antihypertensive drugs is far from being used in clinical practice. In this review, we analyze the main findings available in PubMed from 2010 to 2015, in relation to the major classes of antihypertensive drugs. We also describe a new Phase II drug that targets two specific hypertension predisposing mechanisms

    Stiretrus loratus Germar 1839

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    <i>Stiretrus loratus</i> Germar, 1839 <p>(Fig. 3D)</p> <p> <b>Examined material</b> (n: 1). FRENCH GUIANA.— <b>Cayenne</b>, ♀ 1898, coll. Noualhier, identified as <i>S. loratus</i> by Schouteden (coll. MNHN).</p> <p> <b>Distribution</b>. Argentina, Bolivia, Brazil, French Guiana.</p> <p> <b>Comments</b>. New record of this species in French Guiana.</p>Published as part of <i>Lupoli, Roland, 2019, First catalogue of the Asopinae (Hemiptera, Pentatomidae) from French Guiana, pp. 76-88 in Zootaxa 4668 (1)</i> on page 82, DOI: 10.11646/zootaxa.4668.1.4, <a href="http://zenodo.org/record/3448993">http://zenodo.org/record/3448993</a&gt

    Prevalence of thyroid autoimmunity in patients with spondyloarthropathies.

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    We studied the prevalence of chronic autoimmune thyroiditis or Hashimoto's thyroiditis (HT) in a group of patients with spondyloarthritis (SpA). We evaluated serum levels of thyroid-stimulating hormone, free triiodothyronine, and free thyroxine, and titers of antithyroglobulin and antithyroid peroxidase (anti-TPO) antibodies in 357 consecutive patients with SpA. We also recruited 318 healthy age-matched controls. Ultrasonography of the thyroid gland was performed in all subjects and rheumatic activity was evaluated. Indices of thyroid autoimmunity were significantly more frequent in patients with SpA than in controls (24.09% vs 10.69%, respectively; p 2 years had a higher prevalence of HT and anti-TPO antibodies positivity than patients with a disease duration ≤ 2 years. Ultrasonography detected a significantly higher frequency of thyroid nodules and hypoechoic pattern in patients with SpA than in controls. Among patients with SpA, HT and anti-TPO antibodies positivity were significantly more frequent in patients with peripheral involvement (68.6%) than in patients with axial involvement (31.4%; p < 0.05). Our study shows a significantly higher prevalence of thyroid autoimmunity in patients with SpA as compared to controls. Thyroiditis occurs more frequently in patients with longer disease duration and active rheumatic disease. We suggest that thyroid function tests be part of the clinical evaluation in patients with SpA

    Clinical outcome in differentiated thyroid carcinoma and microcarcinoma

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    INTRODUCTION: Due to the frequent use of neck ultrasonography, the incidence of differentiated thyroid microcarcinoma (DTMC), defined as a lesion with greatest dimension ≤1 cm, is increasing worldwide. Although DTMC generally has a lower aggressivity and a better prognosis than differentiated thyroid carcinoma (DTC), some cases of clinically aggressive DTMC were found. The aim of this study is to compare the rate of recurrence in DTMC and DTC, during a 3-year follow-up. METHODS: Patients with differentiated thyroid carcinoma, who underwent total thyroidectomy and postoperative (131)I-RAI ablation, were stratified according to lesion diameter (DTC for diameter > 1 cm or DTMC ≤ 1 cm). After surgery, patients underwent a 3-year follow-up. Recurrent disease was defined on the basis of positive biochemical (Tg > 2 ng/ml under TSH-suppression or after rhTSH-stimulation) and/or imaging (US, WBS, CT, PET/CT) findings. RESULTS: 449 patients have been included in the final analysis. Linfoadenectomy rate and RAI ablative dose were significantly higher in DTC than in DTMC (32.7% vs. 22.4%, p = 0.018 and 112.3 ± 21 vs. 68.3 ± 24.1 mCi, p < 0.001). During the follow-up, 50 carcinoma recurrences occurred, more frequent in DTC than in DTMC (15.6% vs. 7.6%, p = 0.010). After adjustment for gender, age, rate of lymph node dissection and 131I dose of RAI treatment, the difference in the risk of recurrence was no longer significant among DTC and DTMC patients (HR: 1.585, 95% CI 0874-2877, p = 0.130). CONCLUSIONS: The prediction of disease severity cannot be based exclusively on lesion diameter. A more careful therapeutic approach and follow-up should be recommended in DTMC patients
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