184,267 research outputs found
Neurocognitive and Psychotiform Behavioral Alterations and Enhanced Hippocampal Long-Term Potentiation in Transgenic Mice Displaying Neuropathological Features of Human α-Mannosidosis
No full textD'Hooge R, Lüllmann-Rauch R, Beckers T, et al. Neurocognitive and Psychotiform Behavioral Alterations and Enhanced Hippocampal Long-Term Potentiation in Transgenic Mice Displaying Neuropathological Features of Human α-Mannosidosis. Journal of Neuroscience. 2005;25(28):6539-6549
Disease model: LAMP-2 enlightens Danon disease
No full textDanon disease ('lysosomal glycogen storage disease with normal acid maltase') is characterized by a cardiomyopathy, myopathy and variable mental retardation. Mutations in the coding sequence of the lysosomal-associated membrane protein 2 (LAMP-2) were shown to cause a LAMP-2 deficiency in patients with Danon disease. LAMP-2 deficient mice manifest a similar vacuolar cardioskeletal myopathy. In addition to the patient reports LAMP-2 deficiency in mice causes pancreatic, hepatocytic, endothelial and leucocyte vacuolation. LAMP-2 deficient mice represent a valuable animal model of Danon disease. They will further be used to study the exact role of LAMP-P in autophagy and to analyse the consequences of an impaired autophagic pathway in various tissues
Letter from Fred R. Rauch to Benjamin M. Schowe, January 12, 1940
No full textAn abbreviated letter from Rauch to Schowe clarifying Work Projects Administration regulationsMade available in DSpace on 2005-08-24T14:39:04Z (GMT). No. of bitstreams: 3
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Previous issue date: 2005-06-2
Letter from Fred R. Rauch to Benjamin M. Schowe, May 9, 1940
No full textRauch informs Schowe that his issues have been addresse
Letter from Fred R. Rauch to Benjamin M. Schowe, January 12, 1940
No full textRauch explains that the statues do not specifically discriminate against the deaf.Made available in DSpace on 2005-08-24T14:38:59Z (GMT). No. of bitstreams: 6
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Previous issue date: 2005-06-2
Letter from Fred R. Rauch to Benjamin M. Schowe, January 12, 1940
No full textRauch clarifies that federal regulations are more favorable than local regulations in regard to deaf employmen
Letter from Fred R. Rauch to Benjamin M. Schowe, January 12, 1940
No full textRauch explains that the statues do not specifically discriminate against the deaf
Letter from Fred R. Rauch to K.B. Ayers, April 10, 1940
No full textRauch admits the need for revision of the Work Projects Administration regulations regarding deaf worker
Letter from Fred R. Rauch to Benjamin M. Schowe, January 12, 1940
No full textAn abbreviated letter from Rauch to Schowe clarifying Work Projects Administration regulation
Telegram from Fred R. Rauch to Benjamin M. Schowe, April 16, 1940
No full textRauch informs Schowe he cannot meet with him in person but will send a member of his staff in his stea
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