2,427 research outputs found
Opere del conte Algarotti.
No full textIncludes index in vol. 7.Added t.p. in vol. 1, engraved by Giuseppe Patrini. Engraved portrait medallion of the author on t.p. in vol. 1, small woodcut title-vignettes on title pages in vol. 2-10.Mode of access: Internet
Il museo delle linee d'ombra. Protezione e valorizzazione del sito archeologico di Santa Lucia alle Malve.
No full textIn ricordo di Amedeo G. Conte
No full textThe focus is devoted to the Memory of Amedeo G. Conte. After an Introduction by Tecla Mazzarese, the focus collects papers by Paolo Di Lucia and Lorenzo Passerin Glazel, Antonio Incampo, Giuseppe Lorini and Wojciech Żełaniec on Conte's most relevant contributions to legal philosophy, logics and linguistics
La sepoltura di Ruggero conte di Calabria,
No full textSi ricostruisce il sepolcro di Ruggero conte di Calabria, con un baldacchino in porfido e un sarcofago romano, inserendo il monumento nel suo contesto storico e culturale
Amedeo Giovanni Conte filosofo della validità
No full textOne of the most relevant contributions given by Amedeo G. Conte to the investigation of normative phenomena is his theory of the validity of norms. But what is the real object of a theory of the validity of norms? And what is a norm? This paper revisits the developments of Conte’s theory of validity and highlights the pragmatical and ontological turn that led Conte to introduce the concept of deontic state-of-affairs and to abandon a strictly linguistic conception of normative phenomena
Molecular pathways: the complexity of the epigenome in cancer and recent clinical advances.
No full textHuman cancer is causally linked to genomic and epigenomic deregulations. Epigenetic abnormalities occurring within signaling pathways regulating proliferation, migration, growth, differentiation, transcription and death signals may be critical in the progression of malignancies. Consequently, identification of epigenetic marks and their bio-implications in tumors represents a crucial step towards defining new therapeutic strategies both in cancer treatment and prevention. Alterations of writers, readers and erasers in cancer may affect, for example, the methylation and acetylation state of huge areas of chromatin, suggesting that epi-based treatments may require "distinct" therapeutic strategies compared to "canonical" targeted treatments. Whereas anticancer treatments targeting HDACs (HDAC inhibitors) and DNA methylation have entered the clinic, additional chromatin modification enzymes have not yet been pharmacologically targeted for clinical use in patients. Thus, a greater insight into alterations occurring on chromatin modifiers and their impact in tumorigenesis represents a crucial advancement in exploiting epigenetic targeting in cancer prevention and treatment. Here, the interplay of the best-known epi-mutations and how their targeting might be optimized will be addressed
Genetic diversity, reproductive biology and conservation strategies of endangered species
No full textThe authors examined the relatio nship between the amount of genetic diversity and some bio-logical and populational characteristics (p loidy level, ratio of allogamy vs. autogamy, popula-tion size, existence and distance of other populations of th e same spec ies). Some case studies served to demo nstrate that genetic divers ity cannot be reliably predicted a-priori, because it depends on the interactio n of several factors. The importance of historical factors in determin-ing infraspecific diversity is stressed. The authors conclude that reliable (i.e. directly measured) estimates of genetic diversity, both within populations and within individuals, are necessary in order to determine if a plant species is in need of conservation, to de fine conservation strategies, and to se lect germplasm sources for in situ or ex situ conservation
Searle vs. Conte on Constitutive Rules
No full textThe concept of “constitutive rule” is inextricably linked with the philosophy of John R. Searle. It is less known, however, that starting from the ‘70s, a discussion on constitutive rules emerged in Italian legal philosophy that reached a level of complexity and depth hardly matched in the rest of the world. This is due primarily to the work of two main authors: Gaetano Carcaterra and Amedeo G. Conte. This paper takes a step forward in connecting these two sources: It shows how the evolution of Searle’s concept of constitutive rule can be the ground for a criticism of Conte’s concept of constitutive rule, and how, conversely, that same evolution is coherent with a well-grounded criticism by Conte of Searle’s original theory
Gonadotropin-releasing hormone analogues for the prevention of chemotherapy-induced premature ovarian failure in breast cancer patients
No full textSince the survival of patients with cancer has significantly improved, chemotherapy-related premature ovarian failure (POF) in young cancer survivors has become a major issue in oncology. POF is associated with several health-related negative consequences, including menopausal symptoms, increased risk of cardiovascular diseases, osteoporosis, sexual dysfunction, and infertility. According to the major international guidelines, embryo/oocyte cryopreservation are the standard procedures for fertility preservation in young cancer women. However, these techniques do not protect the whole ovarian function from the gonadotoxicity of anticancer therapies; indeed, they can only preserve fertility without preventing POF and related side effects. In recent years, temporary ovarian suppression during chemotherapy with lutenising hormone-releasing hormone analogues (LHRHa) has emerged as an option to preserve both gonadal function and fertility. Despite temporary ovarian suppression with LHRHa showed to be an effective strategy to reduce the risk of treatment-related POF in several randomized clinical trials, its use as a standard procedure is still under debate. The present review will encompass the current evidences and controversies on the efficacy and safety of ovarian protection with LHRHa during chemotherapy for preservation of ovarian function and fertility in breast cancer patients, in light of the new data published
Il paradigma Quid ius? vs. Quid iuris? : oltre Immanuel Kant
No full textLo studio propone una nuova interpretazione del celebre passo di Kant nel quale egli distingue due domande relative al diritto: la domanda del giurista (quid iuris?) e la domanda del filosofo (quid ius?)
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