63 research outputs found
Pour une "littérature appliquée": le storytelling et les mondes professionnels, un état de l'art
No full textThe idea of cooperation between academic and extra-academic worlds is still seen as part of a general debate about the amendment of higher education system. The core issue of this debate is how to make the education closer to the world of work strengthening the relations between the universities, the businesses and the institutions. This means to reach a "state of the art" in terms of opportunities and challenges, to match better the skills provided by liberal arts education with the requirements of the world of business. Thus, we’ll try to draw as complete picture as possible of professional development paths in humanities in order to promote higher results capable to meet the expectations of extra-academic world. The author offers an overview of storytelling and its applications in different fields of the world of work in order to facilitate the advent of an "applied literature".L’idée d’une coopération entre deux univers – l’académique et l’extra-académique – appartient, depuis des décennies, au débat sur une reconfiguration générale des pratiques éducatives supérieures, visant à articuler plus étroitement éducation et travail et à renforcer les relations de l’université vis-à-vis du monde des entreprises et des institutions. Cela signifie l'atteinte d'un "état sur l'art" en termes de possibilités et de défis, afin de mieux adapter les compétences acquises par une formation en sciences humaines aux exigences du monde de l'entreprise et du travail. On cherchera donc à esquisser un portrait aussi exhaustif que possible du problème de la professionnalisation en sciences humaines, de la promotion et des résultats de la professionnalisation ainsi que des attentes du monde extra-académique. L’auteur propose un panorama sur le storytelling et ses « usages » dans des secteurs variés du monde du travail afin de faciliter l’avènement d’une « littérature appliquée »
A fuzzy-based scoring rule for author ranking
No full textThe measurement of the quality of research has reached nowadays an increasing interest not only for scientific reasons but also for the critical problem of researchers' ranking, due to the lack of grant assignments. The most commonly used approach is based on the so-called h-index, even if the current literature debated a lot about its pros and cons. This paper, after a brief review of the h-index and of alternative models, focuses on the characterization and the implementation of a modified scoring rule approach by means of a fuzzy inference system a là Sugeno.The measurement of the quality of research has reached nowadays an increasing interest not only for scientific reasons but also for the critical problem of researchers' ranking, due to the lack of grant assignments. The most commonly used approach is based on the so-called h-index, even if the current literature debated a lot about its pros and cons. This paper, after a brief review of the h-index and of alternative models, focuses on the characterization and
the implementation of a modified scoring rule approach by means of a fuzzy inference system a là Sugeno
Human sinusoidal subendothelial cells regulate homing and invasion of circulating metastatic prostate cancer cells to bone marrow
No full text: Subendothelial cells (pericytes) are the clonogenic, multipotent and self-renewing skeletal stem cells (SSCs) found in bone marrow (BM) stroma. They express genes maintaining hematopoietic stem cell (HMC) niche identity and, transplanted in immunocompromised mice, organize the hematopoietic microenvironment (HME) generating humanized bone/BM ossicles. To create a mouse model of hematogenous metastasis of human prostate cancer (PC) cells to human bone/BM, we injected PC cells in the blood circulatory system of Severe Combined Immunodeficiency (SCID)/beige mice bearing heterotopic ossicles. Results indicate that PC cells could efficiently home to mice-implanted extraskeletal BM ossicles, but were not able to colonize mice skeletal segments. In humanized bone/BM ossicles, early foci of PC cells occupied a perisinusoidal position, in close contact with perivascular stromal cells. These findings demonstrate the importance of the SSC compartment in recreating a suitable environment to metastatic PC cells. Our data support the hypothesis that BM SSCs committed to a pericyte fate can specify for homing niches of PC cells, suggesting an involvement of specific interactions with subendothelial stromal cells in extravasation of circulating metastatic PC cells to BM
Metal-Enhanced Fluorescence Immunosensor Based on Plasmonic Arrays of Gold Nanoislands on an Etched Glass Substrate
No full textThe recent advances in nanofabrication processes offer encouraging opportunities for designing highly sensitive detection tools. One example is metal-enhanced fluorescence (MEF)-based biosensors: by effectively coupling the metal nanostructures with the fluorescent dye used for the detection of the target molecule, MEF-based sensors exhibit higher sensitivity and lower limit of detection in comparison to traditional optical biosensors. Ordered arrays of nanostructures with coupled fluorophores can potentially achieve thousand-fold enhancement in fluorescence intensity. However, nanofabrication techniques required for ordered nanostructures tend to be time consuming and costly. On the other hand, with moderate enhancement, randomly assembled nanoplasmonic arrays on large-scale substrates can be realized by easy, cost-effective, and reliable methodologies in a relatively short time, thus being more suitable for mass production. In this work, we develop a MEF-based immunosensor involving randomly assembled plasmonic arrays of gold nanoparticles fabricated by a simple and versatile three-step process to modulate the size, the interparticle distance, and the optical properties of the gold nanostructures to achieve the optimal fluorescence enhancement. Specifically, we have tested three different fluorescent dyes (Alexa Fluor 488, Alexa Fluor 546, and PE-Cy7) coupled with optimized gold nanostructures and achieved up to approximate to 170-fold enhancement in the fluorescence emission, significantly better than those achieved by metal nanostructures in solutions and by randomly assembled nanoplasmonic arrays. Our MEF immunosensor is then employed for detecting immunoglobulins in a model antigen-antibody system, achieving a limit of detection of 4.3 ng/mL. This value is lower than that of similar immunoglobulin detection assays and offers promising opportunities for a wide range of biosensing applications
A Fuzzy-based Scoring Rule for Author Ranking: an alternative to h-index
No full textThe measurement of the quality of research has reached nowadays an increasing interest not only for scientific reasons but also for the critical problem of researchers' ranking, due to the lack of grant assignments. The most commonly used approach is based on the so-called h-index, even if the current literature debated a lot about its pros and cons. This paper, after a brief review of the h-index and of alternative models, focuses on the characterization and the implementation of a modified scoring rule approach by means of a fuzzy inference system a là Sugeno
CWL-PLAS: Task Workflows Assisted by Data Science Cloud Platforms
No full textThe Common Workflow Language (CWL) is a platform-independent description language for the representation of data science workflows consisting of a set of tasks that interact with each other to perform scientific analysis. The tasks can be packaged as Linux containers. On the one hand, using containers ensures the reproducibility and portability of workflows. Still, on the other hand, it limits each task to exploiting, at most, the resources of the host where its container runs. In this paper, we propose CWL-PLAS, an extension of CWL that allows a task to instantiate and temporarily use a supporting cloud platform for parallel computing, which is specialized for the task’s activity. In this way, tasks can leverage the resources of multiple hosts in parallel, reducing the duration of the workflow. We implemented an open-source workflow manager that supports CWL-PLAS workflows and exploits a Kubernetes back-end. We used this workflow manager to evaluate the performance of CWL-PLAS in a couple of machine learning workflows
A HISTÓRIA, SUAS FONTES E SUAS ESCRITURAS
No full textEm Fontes históricas, Carla Bassanezi Pinsky, Carlos Bacellar, Jorge Grespan, Marcos Napolitano, Maria de Lourdes Janotti, Pedro Paulo Funari, Tania Regina de Luca, Vavy Pacheco Borges e Verena Alberti, apresentaram-nos discussões instigantes sobre o trabalho com fontes, base primordial para o ofício do historiador, como as armazenadas nos arquivos, as de caráter arqueológico (vinculadas à cultura material), as impressas (em especial, das publicações sequenciais, como jornais e revistas), as orais (suas variações, formas de coleta, armazenamento e análise), as biográficas (e sua fortuna crítica e mudanças), as audiovisuais e as de cunho historiográfico, como o próprio livro em pauta – como destacaria o ensaio de Janotti
A fuzzy-based scoring rule for author ranking
No full textThe measurement of the quality of research has reached nowadays an increasing interest not only for scientific reasons but also for the critical problem of researchers' ranking, due to the lack of grant assignments. The most commonly used approach is based on the so-called -index, even if the current literature debated a lot about its pros and cons. This paper, after a brief review of the -index and of alternative models, focuses on the characterization and the implementation of a modified scoring rule approach by means of a fuzzy inference system a là Sugeno.Research evaluation, bibliometrics, author ranking, -index, scoring rules, fuzzy inference system.
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