22 research outputs found
Spread and establishment of Aedes albopictus in southern Switzerland between 2003 and 2014 : an analysis of oviposition data and weather conditions
No full textThe Asian tiger mosquito, Aedes albopictus, is a highly invasive mosquito species of public health importance. In the wake of its arrival in neighbouring Italy the authorities of the canton of Ticino in southern Switzerland initiated a surveillance programme in 2000 that is still on-going. Here we explored the unique data set, compiled from 2003 to 2014, to analyse the local dynamic of introduction and establishment of Ae. albopictus, its relative density in relation to precipitation and temperature, and its potential distribution at the passage from southern to northern Europe.; The presence of Ae. albopictus was recorded by ovitraps placed across Ticino. In addition to presence-absence, the relationship between relative egg densities and year, month, temperature and precipitation was analysed by a generalised linear mixed model.; Since its first detection in 2003 at Ticino's border with Italy Ae. albopictus has continuously spread north across the lower valleys, mainly along the trans-European motorway, E35. Detailed local analysis showed that industrial areas were colonised by the mosquito before residential areas and that, afterwards, the mosquito was more present in residential than in industrial areas. Ae. albopictus appeared sporadically and then became more present in the same places the following years, suggesting gradual establishment of locally reproducing populations that manage to overwinter. This trend continues as witnessed by both a growing area being infested and increasing egg counts in the ovitraps. There was a clear South-North gradient with more traps being repeatedly positive in the South and fewer eggs laid during periods of intensive precipitation. In the North, the mosquito appeared repeatedly through the years, but never managed to establish, probably because of unfavourable weather conditions and low road traffic.; Given the present results we assume that additional areas may still become infested. While the current study provides good estimates of relative egg densities and shows the local and regional dynamics of Ae. albopictus invasion, additional parameters ought to be measured to make an objective risk assessment for epidemic disease transmission. The likelihood of Ae. albopictus to further spread and increase in densities calls for continued surveillance
Is Switzerland suitable for the invasion of Aedes albopictus [corrected]?
No full textBackgroundOver the last 30 years, the Asian tiger mosquito, Aedes albopictus, has rapidly spread around the world. The European distribution comprises the Mediterranean basin with a first appearance in Switzerland in 2003. Early identification of the most suitable areas in Switzerland allowing progressive invasion by this species is considered crucial to suggest adequate surveillance and control plans.Methodology/principal findingsWe identified the most suitable areas for invasion and establishment of Ae. albopictus in Switzerland. The potential distribution areas linked to the current climatic suitability were assessed using remotely sensed land surface temperature data recorded by the MODIS satellite sensors. Suitable areas for adult survival and overwintering of diapausing eggs were also identified for future climatic conditions, considering two different climate change scenarios (A1B, A2) for the periods 2020-2049 and 2045-2074. At present, the areas around Lake Geneva in western Switzerland provide suitable climatic conditions for Ae. albopictus. In northern Switzerland, parts of the Rhine valley, around Lake Constance, as well as the surroundings of Lake Neuchâtel, appear to be suitable for the survival at least of adult Ae. albopictus. However, these areas are characterized by winters currently being too cold for survival and development of diapausing eggs. In southern Switzerland, Ae. albopictus is already well-established, especially in the Canton of Ticino. For the years 2020-2049, the predicted possible spread of the tiger mosquito does not differ significantly from its potential current distribution. However, important expansions are obtained if the period is extended to the years 2045-2074, when Ae. albopictus may invade large new areas.Conclusions/significanceSeveral parts of Switzerland provide suitable climatic conditions for invasion and establishment of Ae. albopictus. The current distribution and rapid spread in other European countries suggest that the tiger mosquito will colonize new areas in Switzerland in the near future
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No full text, has rapidly spread around the world. The European distribution comprises the Mediterranean basin with a first appearance in Switzerland in 2003. Early identification of the most suitable areas in Switzerland allowing progressive invasion by this species is considered crucial to suggest adequate surveillance and control plans. may invade large new areas.. The current distribution and rapid spread in other European countries suggest that the tiger mosquito will colonize new areas in Switzerland in the near future
COMBINATORIAL THEOREMS FOR THE CONSTRUCTION OF MODELS**These results were obtained while the author was working on a research project in the foundations of mathematics at the University of California, Berkeley, U.S. National Science Foundation Grant G-19673.
No full textSurveillance and control of Aedes albopictus in the Swiss-Italian border region: differences in egg densities between intervention and non-intervention areas
No full textBACKGROUND: Aedes albopictus, the Asian tiger mosquito, originates from the tropical and subtropical regions of Southeast Asia. Over the recent decades it has been passively spread across the globe, primarily through the used tyre trade and passive transportation along major traffic routes. A. albopictus is a proven vector for many arboviruses, most notably chikungunya and dengue, with recent outbreaks also in continental Europe. In southern Switzerland, in the Canton of Ticino A. albopictus was spotted for the first time in 2003. Since then the local authorities have implemented a control programme based on larval source reduction. Despite these efforts, mosquito densities have increased over the last decade, casting doubts on the effectiveness of such larval control programmes.
METHODOLOGY/PRINCIPAL FINDINGS: The Italian communities just across the Swiss-Italian border lack a control programme. This motivated us to compare the intervention and the non-intervention areas side by side in an attempt to find evidence for, or against, the effectiveness of larval A. albopictus control. Using ovitraps and a randomised sampling scheme, we examined the seasonal and spatial abundance of A. albopictus in sylvatic and urban environments across the Swiss-Italian border in 2012 and 2013. In the urban environments of the non-intervention area, egg densities were 2.26 times higher as compared to the intervention area. In the sylvatic environments, as compared to the urban environments, egg densities were 36% in the intervention area and 18% in the non-intervention area.
CONCLUSIONS/SIGNIFICANCE: Though alternative explanations are also valid, the results support the hypothesis that the Ticino intervention programme does have an impact. At the same time the data also suggest that current larval interventions fall short in gaining full control over the mosquito, calling for the evaluation of additional, or alternative, approaches. Ideally, these should also consider inclusion of the neighbouring Italian communities in the surveillance and control efforts
Safety and quality of cystectomy and pelvic lymph node dissection after neoadjuvant durvalumab and cisplatin/gemcitabine.
No full textOBJECTIVE
To report on the surgical safety and quality of pelvic lymph node dissection (PLND) in patients treated with radical cystectomy (RC) and PLND for muscle-invasive bladder cancer (MIBC) after neoadjuvant chemo-immunotherapy.
PATIENTS AND METHODS
The Swiss Group for Clinical Cancer Research (SAKK) 06/17 was an open-label single-arm phase II trial including 61 cisplatin-fit patients with clinical stage (c)T2-T4a cN0-1 operable urothelial MIBC or upper urinary tract cancer. Patients received neoadjuvant cisplatin/gemcitabine and durvalumab followed by surgery. Prospective quality assessment of surgeries was performed via central review of intraoperative photographs. Postoperative complications were assessed using the Clavien-Dindo Classification. Data were analysed descriptively.
RESULTS
A total of 50 patients received RC and PLND. All patients received neoadjuvant chemo-immunotherapy. The median (interquartile range) number of lymph nodes removed was 29 (23-38). No intraoperative complications were registered. Grade ≥III postoperative complications were reported in 12 patients (24%). Complete nodal dissection (100%) was performed at the level of the obturator fossa (bilaterally) and of the left external iliac region; in 49 patients (98%) at the internal iliac region and at the right external iliac region; in 39 (78%) and 38 (76%) patients at the right and left presacral level, respectively.
CONCLUSION
This study supports the surgical safety of RC and PLND following neoadjuvant chemo-immunotherapy in patients with MIBC. The extent and completeness of protocol-defined PLND varies between patients, highlighting the need to communicate and monitor the surgical template
The invisible scissors: Media freedom and censorship in Switzerland
No full textThis thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.At first glance, the very idea of analysing the freedom of the media and of researching
censorship in Switzerland seems absurd. After all, the Federal Constitution explicitly guarantees freedom of the media, and censorship is forbidden. Furthermore, this small, federal, multilingual and multicultural landlocked country in the middle of Europe is universally praised as a model of democracy. Indeed, in a country whose people have a far greater say in government than anywhere else, one could easily assume that the freedom of the media is a foregone conclusion.
Yet, in reality, this shining image is more than a little tarnished. The "Prototype for
Europe" – as the former Federal President of Germany Richard von Weizsäcker once described Switzerland – experiences the same forms and mechanisms of censorship as any other democratic country. Of course, in Switzerland "undesirable" journalists are
not threatened with murder, but critically discerning authors do risk becoming social
outcasts. Switzerland prohibits governmental pre-censorship, but the advertising
industry has on occasion attempted to shape the content of the media by means of
post-publication censorship in the form of boycotts. Switzerland is a constitutional state, yet the paragraphs of its penal and civil codes hang over media workers like the sword of Damocles. Then there are structural problems such as the lack of proper journalistic education. However one looks at it, the freedom of the media in Switzerland is officially, materially and structurally restricted.
However, most people remain unconcerned by and indeed unaware of this state of affairs. Thomas Jefferson's reminder that, "to preserve the freedom of the human mind then and freedom of the press, every spirit should be ready to devote itself to
martyrdom; for as long as we may think as we will, and speak as we think, the condition of man will proceed in improvement”*, has long been forgotten in Switzerland.
The Swiss appear to be basking in their country’s reputation as a place without media
problems. It therefore came as no surprise to us when, both in our quantitative and
qualitative research, many of those interviewed were surprised and even irritated at our 2 questions about possible threats to freedom of the media in Switzerland. Some people even felt that they were being personally attacked and responded along the lines that "Instead of fouling our own nest we ought to describe the advantages of our country and our democratic system". Or: "In comparison with Russia or China we are living in a paradise": It seems that only the most critical among the media personnel, media experts and media scientists are willing to pinpoint the problems faced by the contemporary Swiss media. All the others are convinced that we have the best media on earth.
This attitude of part indifference, part ignorance and part wishful thinking, was the
catalyst for our research on the freedom of the Swiss media and the potential dangers
and mechanisms which threaten it. Our findings reveal that all that glitters is not gold and that the Swiss media scene is, in some ways, reminiscent of a Potemkin village. *Jefferson, Thomas, Letter to William Green Mumford, 18 June 1799
(http://www.positiveatheism.org/hist/quotes/jefferson.htm, consulted 15 June 2006
Suitability indicators for adult <i>Ae. albopictus</i> in Switzerland in 2060 (2045–2074).
No full text<p>The maps in the first column are based on temperature estimates for the climate changes scenario A1B, the maps in the second column are based on temperature estimates for the climate changes scenario A2. The coloring scheme shows the gradient of suitability, from 0.0 (unsuitable areas: white colored) to 1.0 (highly suitable areas: red colored).</p
Comparison of models for current habitat suitability.
No full text<p>In contrast to previously published approaches based on ECA&D, high resolution temperature data allow for the correct detection of areas suitable for <i>Ae. albopictus</i> in valleys. Dots in the maps for Canton Ticino indicate known presence of <i>Ae. albopictus</i>.</p
