229,250 research outputs found
Complement Signals Determine Opposite Effects of B Cells in Chemotherapy-Induced Immunity
No full textData files for: Lu Y., Zhao Q., Liao J.Y., Song E., Xia Q., Pan J., Li Y., Li J., Zhou B., Ye Y., Di C., Yu S., Zeng Y., Su S. Complement Signals Determine Opposite Effects of B Cells in Chemotherapy-Induced Immunity. Cell 2020
La traducción literal del escritor Lu Xun (1881-1936) como impulso a la lengua vernácula (baihua) y a la nueva literatura en China
No full texta partir de la mitad del siglo XIX, China empezó a enfrentarse a la hegemonía y la invasión de las potencias occidentales. algunos intelectuales utilizaron la traducción como herramienta para introducir los estudios occidentales en China, sobre todo los de tecnología y filosofía, con el fin de favorecer la modernización de la sociedad. Otros intelectuales aprovecharon la traducción para estimular la evolución literaria y el paso hacia la lengua vernácula, el baihua. Entre ellos se encuentra el escritor Lu Xun (1881-1936), que defendia la traducción literal como motor para hacer evolucionar la lengua clásica hacia el baihua. Consideraba que mediante el baihua se podía lograr una literatura más cercana al pueblo y así educarlo. al mismo tiempo, la traducción de Lu Xun conllevaba cierta manipulación ideológica del traductor. Las obras traducidas por él, en general, presentaban personajes sufridos y revelaban la injusticia social. Lu Xun quería que los chinos aprendieran de estas obras literarias. Por otro lado, desde una óptica contemporánea, la opinión de Lu Xun y su insistencia en adoptar una traducción literal encuentra un paralelismo en la extranjerización que defiende Lawrence Venuti a la hora de oponerse a una lectura “fluida”. Salvando las distancias, tanto Lu Xun como Venuti señalan que el exotismo puede acercar la cultura extranjera a la literatura meta y, en cierto sentido, evitar la hegemonía de cada época.補正完畢國外Y電子版紙本ES
Síntesis y caracterización de granates del tipo Sm3-xTRxFe5O12 (TR = Dy, Gd, Lu y La)
Full text linkLos granates de tierras raras (TR3Fe5O12) presentan propiedades magneto-eléctricas y ópticas que permiten su aplicación en transformadores, dispositivos de microondas y de almacenamiento de datos. Estas propiedades dependen de su estructura y morfología, que son altamente influenciadas por la sustitución parcial o total de los sitios catiónicos, así como por el método de síntesis. El presente trabajo se enfocó en la obtención de los nuevos granates de formula Sm3-xTRxFe5O12 (TR= Gd, Dy, Lu y La) con x=0.0, 0.1, 0.2, 0.4, 0.6, 0.8 y 1.0 sintetizados por los métodos citrato y cerámico, con el fin de evaluar la influencia del catión sustituyente y método sobre sus propiedades. La caracterización por DRX, Raman, MEB, EDX, VSM y medida de resistividad, demostró la adecuada sustitución del Sm por Lu, Dy y Gd favoreciendo la obtención de materiales de fase pura, de estructura cúbica y con grupo espacial Ia-3d (230). En contraste, el La llevó a la formación de fases de Sm1-xLaxFeO3 lo que se explica en función de su radio iónico. El método citrato favoreció la obtención de granates con partículas de menor tamaño ( 1 µm) y de carácter ferrimagnético, de mayor Hc y Ms menor en comparación con las muestras obtenidas por el método cerámico, con un tiempo y temperatura de calcinación menores en 18 h y 300 °C. Los resultados obtenidos permiten concluir que las muestras del sistema Sm3-xTRxFe5O12 (TR= Gd, Dy, Lu) presentan potenciales aplicaciones en transformadores y conmutadores de microondas, con una importante disminución en los costos de producción.Abstract. Rare earth garnets (TR3Fe5O12) have magneto-electric and optical properties that allow their application in transformers, microwave and data storage devices. These properties depend on their structure and morphology, which are influenced by the partial or total substitution of the cationic sites, as well as by the synthesis method. The present work focused in the obtaining of new garnets with formula Sm3-xTRxFe5O12 (TR = Gd, Dy, Lu and La) with x = 0.0, 0.1, 0.2, 0.4, 0.6, 0.8 and 1.0 synthesized by method citrate and ceramic method, in order to evaluate the influence of substituent cation and. Synthesis method on their properties. The characterization by XRD, Raman, MEB, EDX, VSM and resistivity measurement, demonstrated the adequate substitution of Sm by Lu, Dy and Gd favoring the obtaining of pure phase materials with cubic structure and space group Ia-3d (230). on the other hand, the substitution with La carried generated the formation of phases of Sm1-xLaxFeO3 which is explained according to its ionic radius. The citrate method favored the obtaining of garnets with particles of smaller size (1 μm), ferrimagnetic character, of higher HC and smaller MS compareted to the samples obtained by the ceramic method, with a calcination temperature and time even 300 °C and 18 h below. The results obtained allow to conclude that samples of the Sm3-xTRxFe5O12 system (TR = Gd, Dy, Lu) present potential applications in transformers and microwave switches, with a significant decrease in production costs.Maestrí
Chao Yuen Ren (1892–1982)
No full textY. R. Chao is easily the most famous linguist to have come out of China. Born before the end of the last dynasty in China, he received a traditional Confucian education, but was also one of the first Chinese people to be sent to the West for training in modern Western science (under the Boxer Indemnity Fund). The remarkable breadth and scope of his studies included physics, mathematics, linguistics, musical and literary composition, and translation, and he was a pioneer in many of these fields
Figure 3 from: Lu Z, Sun Y (2019) Rhamnella brachycarpa (Rhamnaceae), a new species from Hainan Island, China. PhytoKeys 132: 19-29. https://doi.org/10.3897/phytokeys.132.36776
No full textFigure 3 Rhamnella brachycarpa Z. Qiang Lu & Y. Shuai Sun, sp. nov., drawn from the tree of Z.Q. Lu 2018HN3001
First preclinical evaluation of [<sup>225</sup>Ac]Ac-DOTA-JR11 and comparison with [<sup>177</sup>Lu]Lu-DOTA-JR11, alpha versus beta radionuclide therapy of NETs
No full textBackground: The [177Lu]Lu-DOTA-TATE mediated peptide receptor radionuclide therapy (PRRT) of neuroendocrine tumors (NETs) is sometimes leading to treatment resistance and disease recurrence. An interesting alternative could be the somatostatin antagonist, [177Lu]Lu-DOTA-JR11, that demonstrated better biodistribution profile and higher tumor uptake than [177Lu]Lu-DOTA-TATE. Furthermore, treatment with alpha emitters showed improvement of the therapeutic index of PRRT due to the high LET offered by the alpha particles compared to beta emitters. Therefore, [225Ac]Ac-DOTA-JR11 can be a potential candidate to improve the treatment of NETs (Graphical abstract). DOTA-JR11 was radiolabeled with [225Ac]Ac(NO3)3 and [177Lu]LuCl3. Stability studies were performed in phosphate buffered saline (PBS) and mouse serum. In vitro competitive binding assay has been carried out in U2OS-SSTR2 + cells for natLa-DOTA-JR11, natLu-DOTA-JR11 and DOTA-JR11. Ex vivo biodistribution studies were performed in mice inoculated with H69 cells at 4, 24, 48 and 72 h after injection of [225Ac]Ac-DOTA-JR11. A blocking group was included to verify uptake specificity. Dosimetry of selected organs was determined for [225Ac]Ac-DOTA-JR11 and [177Lu]Lu-DOTA-JR11. Results: [225Ac]Ac-DOTA-JR11 has been successfully prepared and obtained in high radiochemical yield (RCY; 95%) and radiochemical purity (RCP; 94%). [225Ac]Ac-DOTA-JR11 showed reasonably good stability in PBS (77% intact radiopeptide at 24 h after incubation) and in mouse serum (~ 81% intact radiopeptide 24 h after incubation). [177Lu]Lu-DOTA-JR11 demonstrated excellent stability in both media (> 93%) up to 24 h post incubation. Competitive binding assay revealed that complexation of DOTA-JR11 with natLa and natLu did not affect its binding affinity to SSTR2. Similar biodistribution profiles were observed for both radiopeptides, however, higher uptake was noticed in the kidneys, liver and bone for [225Ac]Ac-DOTA-JR11 than [177Lu]Lu-DOTA-JR11. Conclusion: [225Ac]Ac-DOTA-JR11 showed a higher absorbed dose in the kidneys compared to [177Lu]Lu-DOTA-JR11, which may limit further studies with this radiopeptide. However, several strategies can be explored to reduce nephrotoxicity and offer opportunities for future clinical investigations with [225Ac]Ac-DOTA-JR11.RST/Applied Radiation & Isotope
Two-dimensional quantum Bernoulli process and the related central limit theorem
No full textIn this paper, we introduce a quantum decomposition of a two-dimensional Bernoulli random variable (ζ1,ζ2), where E(ζ1) = E(ζ2) = 0, E(ζ12) = E(ζ 22) = 1 and E(ζ1ζ2) = c (-1, 1). Based on this quantum decomposition, we defined the two-dimensional quantum Bernoulli process and set a corresponding central limit theorem, both in the sense of quantum moments and in the sense of characteristic function
Treatment with (90)Y- and (177)Lu-DOTATOC in patients with metastatic neuroendocrine tumors
No full textBACKGROUND: Treatment with (90)Y- or (177)Lu-DOTATOC has recently been introduced in the palliative treatment of somatostatin receptor-expressing neuroendocrine tumors (NETs). The aim of the study was to present clinical experience with (90)Y- and (177)Lu-DOTATOC therapy in the management of NET. METHODS: To prove suitability for treatment each patient underwent scanning with (111)In-DTPAOC or (68)Ga-DOTATOC positron emission tomography/computed tomography. All patients received [(90)Y-DOTATOC] as initial treatment. In case of disease relapse the treatment was repeated. To avoid side effects of repeated [(90)Y] applications, a switch to [(177)Lu-DOTATOC] was carried out. Clinical, biochemical, and radioimaging responses were documented. RESULTS: Twenty patients with metastatic nonresectable NETs (15 pancreas NETs, 2 midgut NETs, 1 gastrinoma, 1 paraganglioma, 1 NET of unknown primary origin) were included. In 8 patients the treatment was repeated more than once (mean, 3 times; range, 2-5 times). After [(90)Y] treatment moderate toxicity was observed in 8 patients. No serious adverse events were documentable. After restaging, a partial remission was found in 5 patients, stable disease in 11 patients, and tumor progression in 4 patients. CONCLUSIONS: Peptide receptor-targeted radionuclide therapy is a promising, safe, and feasible approach in the palliative therapy of patients with NET
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