15,558 research outputs found
Lu-177-Labeled Hetero-Bivalent Agents Targeting PSMA and Bone Metastases for Radionuclide Therapy
No full textProstate-specific membrane antigen (PSMA) is an excellent
target
for imaging and radionuclide therapy of prostate cancer. Recently,
[177Lu]Lu-PSMA-617 (Pluvicto) was approved by the FDA for
radionuclide therapy. To develop hetero-bivalent agents targeting
both PSMA and bone metastasis, [177Lu]Lu-P17-079 ([177Lu]Lu-1) and [177Lu]Lu-P17-081 ([177Lu]Lu-2) were prepared. In vivo biodistribution studies of [177Lu]Lu-PSMA-617, [177Lu]Lu-1, and [177Lu]Lu-2 in mice bearing PC3-PIP (PSMA positive) tumor showed high
uptake in PSMA-positive tumor (14.5, 14.7, and 11.3% ID/g at 1 h,
respectively) and distinctively different bone uptakes (0.52, 6.52,
and 5.82% ID/g at 1 h, respectively). PET imaging using [68Ga]Ga-P17-079 ([68Ga]Ga-1) in the same mouse model displayed
excellent images confirming the expected dual-targeting to PSMA-positive
tumor and bone. Results suggest that [177Lu]Lu-P17-079
([177Lu]Lu-1) is a promising candidate for further development
as a hetero-bivalent radionuclide therapy agent targeting both PSMA
expression and bone metastases for the treatment of prostate cancer
Geomorphometric assessment of the impacts of dam construction on river disconnectivity and flow regulation in the Yangtze basin
No full textRivers are under increasing pressure from anthropogenic impacts with incremental dam construction, experiencing global and regional alteration due to river disconnectivity, flow regulation, and sediment reduction. Assessing the cumulative impacts of dams on river disconnectivity in large river basins can help us better understand how humans disintegrate river systems and change the natural flow regimes. Using the Yangtze basin as the study area, this study employed three modified metrics (river connectivity index, RCI; basin disconnectivity index, BDI; and the degree of regulation for each river section, DOR) to evaluate the cumulative impacts on river disconnectivity over the past 50 years. The results indicated that the Yangtze had experienced strong alterations, despite varying degrees and spatial patterns. Among the major tributaries, the greatest impact (lowest RCI value) happened in the Wu tributary basin due to the construction of cascade dams on the main stem of the tributary, while the lowest impact (highest RCI value) happened in the Fu tributary basin, which still has no dams on its main stem. Collectively, rivers in the upper Yangtze reaches experienced more serious disturbances than their counterparts in the middle and lower reaches. The BDI results displayed that a substantial part of the Yangtze River, especially the Wu, Min, Jialing, and Yuan tributaries, only maintain connectivity among one to three representative river systems. No part of the Yangtze connects all the 12 representative river systems. This study also revealed that small dams can also exert significant impacts in flow regulation on regional river systems through their sheer number and density. The study results can help promote more environmentally sustainable river management policies in the Yangtze basin
Lu-177-Labeled Hetero-Bivalent Agents Targeting PSMA and Bone Metastases for Radionuclide Therapy
No full textProstate-specific membrane antigen (PSMA) is an excellent
target
for imaging and radionuclide therapy of prostate cancer. Recently,
[177Lu]Lu-PSMA-617 (Pluvicto) was approved by the FDA for
radionuclide therapy. To develop hetero-bivalent agents targeting
both PSMA and bone metastasis, [177Lu]Lu-P17-079 ([177Lu]Lu-1) and [177Lu]Lu-P17-081 ([177Lu]Lu-2) were prepared. In vivo biodistribution studies of [177Lu]Lu-PSMA-617, [177Lu]Lu-1, and [177Lu]Lu-2 in mice bearing PC3-PIP (PSMA positive) tumor showed high
uptake in PSMA-positive tumor (14.5, 14.7, and 11.3% ID/g at 1 h,
respectively) and distinctively different bone uptakes (0.52, 6.52,
and 5.82% ID/g at 1 h, respectively). PET imaging using [68Ga]Ga-P17-079 ([68Ga]Ga-1) in the same mouse model displayed
excellent images confirming the expected dual-targeting to PSMA-positive
tumor and bone. Results suggest that [177Lu]Lu-P17-079
([177Lu]Lu-1) is a promising candidate for further development
as a hetero-bivalent radionuclide therapy agent targeting both PSMA
expression and bone metastases for the treatment of prostate cancer
Lu Ann Hampton Laverty Oberlander
No full textDigital images of Lu Ann Hampton Laverty Oberlander, a Preston Jones play presented by Whittier College’s Theatre Department. The play ran May 12, 13, and 14. Images were taken by the Theatre Department.https://poetcommons.whittier.edu/oberlander/1010/thumbnail.jp
An article on how the author, an amateur runner, ran Cape Elizabeth\u27s Beach to B
No full textAn article on how the author, an amateur runner, ran Cape Elizabeth\u27s Beach to Beacon 10K race last August, with comments on the scenery, the encouraging crowds, and the other runners
Assessment of 5G RAN Features for Integrated Services Provisioning in Smart Cities
No full textIn a 5G Radio Access Network (RAN), different features are offered as solutions to serve traffic with diverse characteristics and requirements, including flexible numerology, (non-)pre-emptive mini-slot based scheduling and network slicing. In this paper, we present an extensive simulation-based assessment of the relative merit of these distinct 5G features in the context of a smart city environment. We further derive the optimal feature combination and associated configuration which best handles the services related to the smart city environment given their performance requirements. The obtained insights confirm the commonly argued potential of slicing, emphasizing that the optimal configuration of the slice-specific numerology depends not only on the nature of the handled services but also on the selected RAN features. Among these features, non-preemptive mini-slot based scheduling and idle resource sharing reveal significant performance potential.Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Network Architectures and Service
PSX804827_supplemental_material – Supplemental material for Land Taking and Electoral Rule Setting: Evidence from Chinese Rural Democracy
No full textSupplemental material, PSX804827_supplemental_material for Land Taking and Electoral Rule Setting: Evidence from Chinese Rural Democracy by Fubing Su, Xi Lu, Xi Zhao and Ran Tao in Political Studies</p
sj-pdf-1-hip-10.1177_09540083211036326 – Supplemental Material for Preparation and characterization of soluble heat-resistant polyimide films containing bis-N-phenyl-benzimidazole
No full textSupplemental Material, sj-pdf-1-hip-10.1177_09540083211036326 for Preparation and characterization of soluble heat-resistant polyimide films containing bis-N-phenyl-benzimidazole by Dandan Li, Chengyang Wang, Shengqi Ma, Hongwei Zhou and Ran Lu in High Performance Polymers</p
Response to Jacques Caton, MD’s comments on the article “Distraction osteogenesis at the proximal third of the ulna for the treatment of Masada type I/IIb deformities in children with hereditary multiple exostoses: a retrospective review of twenty cases” by Lu et al
No full text- …
