444 research outputs found
Scheduling heterogeneous delivery tasks on a mixed logistics platform
No full textLarge e-commerce retailers usually establish their own logistics systems. Such systems make use of their own dedicated fleets but will also use a crowdsourced delivery mode by hiring occasional fleets. These mixed logistics systems with both dedicated and occasional fleets serve both retailers’ internal delivery tasks and external tasks requested by local businesses. This paper studies the problem of scheduling heterogeneous (internal and external) delivery tasks on a mixed logistics platform with multiple depots and two types of vehicles (dedicated and occasional). A delivery task is executed by either a dedicated vehicle or an occasional vehicle. The dedicated vehicles depart from and return to the platform's depots; the occasional vehicles depart from their original location and pick up goods from depots or external pickup locations, fulfill the delivery tasks, and finish their route at the final delivery location. We propose mixed integer programming models and column generation-based solution methods to solve the problem. A computational study is conducted based on a series of randomly generated instances and real-world instances involving 15 depots, 120 internal customers, 15 external delivery tasks, and 38 dedicated and occasional vehicles. The results obtained demonstrate the efficiency of the column generation-based solution methods. Moreover, the effectiveness of the proposed models is validated by a significant cost saving in comparison to intuitive decision rules. A sensitivity analysis is also conducted to derive a number of managerial implications
Themus (Haplothemus) licenti Pic 1938
No full textThemus (Haplothemus) licenti Pic, 1938 Figs. 1 C, 5 B, 7 Themus licenti Pic, 1938: 161. Themus coriaceipennis (Fairmaire, 1889): Wittmer 1983: 224, Figs 43, 111. [Misidentification.] Themus (Haplothemus) licenti: Yang et al., 2013: 7, Fig. 3. Type material examined. Holotype female (MNHN): [p]“CHANSI. S.O. \ 22.VII. 35 ”, [p]“HO CHAN \ 2,255m ”, [h]“ Themus \ licenti n. sp. ”, [h]“ Themus (s.str.) \ coriaceipennis \ (Fairm.) \ det. W. Wittmer”, [p]“ HOLOTYPUS ”. Additional material examined. CHINA: 1 male, 1 female (MHBU): Shanxi, Lishan National Natural Reserve, 12.‒ 20.VII. 2013, leg. Yuan-Yuan Lu; 2 males, 1 female (MHBU): Henan, Songxian, Baiyunshan, 17.VII. 2008, leg. Guang-Lin Xie; 2 males, 1 female (MHBU): Hebei, Zhuolu, Yangjiaping, 10.‒ 24.VII. 2005, leg. Jing Li & Hui-Ran Hua; 1 male, 1 female (MHBU): Beijing, Baihuashan, 1100m, 19.VIII. 2000, leg. Da-Kang Zhou. Distribution. China (Beijing, Hebei, Shanxi, Henan, Shaanxi, Sichuan). Supplementary description. Female. Abdominal sternite VIII (Fig. 5 B) widely and roundly emarginated in middle of posterior margin, which is nearly triangular at apex of lateral portion beside middle emargination. Internal reproductive organ of genitalia (Fig. 7): vagina stout, with diverticulum and spermatheca situated at apex, median oviduct in middle of ventral side; diverticulum boot-shaped, stout, nearly straight at apex and distinctly expanded on dorsal side; spermatheca sac-shaped, slightly short and distinctly expanded apically, provided with a slightly short and thin accessory gland near base; diverticulum and spermatheca surrounded with a strongly sclerotized ring at base, which is confluent in middle and extending to median oviduct on ventral side, the opening of spermatheca arising from middle of the sclerotized ring on dorsal side. Remarks. Themus licenti Pic, 1938 was synonymized with T. coriaceipennis (Fairmaire, 1889) by Wittmer (1983), but recently it was resurrected by Yang et al. (2013). In the present study, the female genitalia of both species and the aedeagus of the latter species were available for comparison, which are distinctly different from each other, so both species were confirmed as valid.Published as part of Su, Junyan, Yang, Yuxia & Yang, Xingke, 2015, Description of three new species related to Themus (Haplothemus) coriaceipennis (Fairmaire, 1889) (Coleoptera: Cantharidae), pp. 375-389 in Zootaxa 4034 (2) on page 383, DOI: 10.11646/zootaxa.4034.2.9, http://zenodo.org/record/23614
Effect of fiber length and dosage on the performance of reed fiber-modified bitumen and mortar
No full textCivil Engineerin
Detect influential points of feature rankings
No full textBackgroundFeature rankings are crucial in bioinformatics but can be distorted by influential points (IPs), which are often overlooked. This study aims to investigate the impact of IPs on feature rankings and propose IPs detection methodMethodWe use a leave-one-out approach to assess each case's influence on feature rankings by comparing rank changes after its removal. The rank changes are measured by a novel rank comparison method that involves using adaptive top-prioritized weights that are adjustable to the distribution of rank changes. Our IP detection method was evaluated on several public datasets.ResultsOur method identified potential IPs in several TCGA gene expression datasets, revealing that IPs can severely distort feature rankings. These rank changes can ultimately affect subsequent analyses such as enriched pathways, suggesting the necessity of IPs detection when deriving feature rankings.ConclusionsIPs significantly impact feature rankings and subsequent analyses; routine IP detection is necessary yet underutilized. Our method is available in the R package findIPs
Survey of ex vivo drug combination effects in chronic lymphocytic leukemia reveals synergistic drug effects and genetic dependencies
No full textDrug combinations that target critical pathways are a mainstay of cancer care. To improve current approaches to combination treatment of chronic lymphocytic leukemia (CLL) and gain insights into the underlying biology, we studied the effect of 352 drug combination pairs in multiple concentrations by analysing ex vivo drug response of 52 primary CLL samples, which were characterized by "omics" profiling. Known synergistic interactions were confirmed for B-cell receptor (BCR) inhibitors with Bcl-2 inhibitors and with chemotherapeutic drugs, suggesting that this approach can identify clinically useful combinations. Moreover, we uncovered synergistic interactions between BCR inhibitors and afatinib, which we attribute to BCR activation by afatinib through BLK upstream of BTK and PI3K. Combinations of multiple inhibitors of BCR components (e.g., BTK, PI3K, SYK) had effects similar to the single agents. While PI3K and BTK inhibitors produced overall similar effects in combinations with other drugs, we uncovered a larger response heterogeneity of combinations including PI3K inhibitors, predominantly in CLL with mutated IGHV, which we attribute to the target's position within the BCR-signaling pathway. Taken together, our study shows that drug combination effects can be effectively queried in primary cancer cells, which could aid discovery, triage and clinical development of drug combinations
Analysis of the microcharacteristics of different kinds of asphalt based on different aging conditions
No full textAsphalt aging often leads to rapid degradation of road performance, which seriously affects the service life of asphalt pavement. Exploring the influence of asphalt oil sources, asphalt grades, and filler types on asphalt microcharacteristics in the asphalt aging process can provide an essential reference to guide asphalt pavement maintenance. In this study, we selected seven kinds of asphalt and three fillers commonly used in China for research. The pressurized aging vessel (PAV) and homemade ultraviolet (UV) aging equipment were used to perform thermo-oxidative aging and UV aging tests, respectively, of asphalt. The microcharacteristics of asphalt before and after aging were analyzed via attenuated total reflectance fourier transformation infrared spectroscopy and nuclear magnetic resonance 1H spectroscopy. The results show that the oil source of asphalt exerted the most significant influence on the microcharacteristics of the aged asphalt, while the effect of the asphalt grade was relatively limited. The addition of fillers did not affect the aging mechanism of asphalt. UV and PAV aging generated apparent differences in the changes in the aged asphalt microstructure.Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Pavement Engineerin
Analysis on the requirements and characteristics of implementing scientific research quality management
No full textTRRAP is essential for regulating the accumulation of mutant and wild-type p53 in lymphoma
No full textTumors accumulate high levels of mutant p53 (mutp53), which contributes to mutp53 gain-of-function (GOF) properties. The mechanisms that underlie such excessive accumulation are not fully understood. To discover regulators of mutp53 protein accumulation, we performed a large-scale RNA interference (RNAi) screen in a Burkitt's lymphoma (BL) cell line model. We identified TRRAP, a constituent of several histone acetyltransferase (HAT) complexes, as a critical positive regulator of both mutp53 and wild-type p53 (wtp53) levels. TRRAP silencing attenuated p53 accumulation in lymphoma and colon cancer models, while TRRAP overexpression increased mutp53 levels, suggesting a role for TRRAP across cancer entities and p53 mutations. Through CRISPR-Cas9 screening, we identified a 109 amino acid region in the N-terminal HEAT repeat region of TRRAP which was crucial for mutp53 stabilization and cell proliferation. Mass spectrometric analysis of the mutp53 interactome indicated that TRRAP silencing caused degradation of mutp53 via the MDM2-proteasome axis. This suggests that TRRAP is vital for maintaining mutp53 levels by shielding it against the natural p53 degradation machinery. To identify drugs that alleviated p53 accumulation similarly to TRRAP silencing, we performed a small molecule drug screen and found that inhibition of histone deacetylases (HDACs), specifically HDACs1/2/3, decreased p53 levels to a comparable extent. In summary, here we identify TRRAP as a key regulator of p53 levels and link acetylation-modifying complexes to p53 protein stability. Our findings may provide clues for therapeutic targeting of mutp53 in lymphoma and other cancers
Chemical and rheological properties of polymer modified bitumen incorporating bio-oil derived from waste cooking oil
No full textThe chemical and rheological properties of polymer modified bitumen incorporating bio-oil derived from waste cooking oil (WCO) were investigated in this paper. At first, the chemical composition and mixing mechanism of the experimental materials were analysed from the perspective of functional group, and the influence of bio-oil on the activation energy was also researched. Then, the effect of bio-oil on the rotational viscosities of polymer modified bitumen and construction temperatures of corresponding mixtures was studied. Finally, the shear and bending rheological properties of polymer modified bitumen containing bio-oil were investigated. The results show that the bio-oil and styrene–butadiene–styrene (SBS) modified bitumen is mainly physically mixed, the addition of bio-oil decreases the activation energy of SBS modified bitumen. Additionally, the SBS modified bitumen containing bio-oil has lower viscosity values, and corresponding mixtures also have lower construction temperatures. Furthermore, the addition of bio-oil in SBS modified bitumen reduces the shear modulus and increases the bending creep compliance, which means bio-oil has positive effect on the low-temperature thermal cracking resistance performance while sacrificing the high-temperature rutting resistance performance to some extent. Therefore, the incorporation of WCO-based bio-oil in polymer modified bitumen is a promising technique to be used in cold regions where the low-temperature problems are more crucial.Accepted Author ManuscriptPavement Engineerin
- …
