4,147 research outputs found
Sectoral allocation by gender of Latin American workers over the liberalization period of the 1990s
Full text linkThe recent restructuring of Latin American economies has renewed interest in the effects of trade liberalization, on labor markets, and on the gender division of labor. The author does not attempt to establish casuality between economic reforms, and the types of jobs that men and women hold. Instead, she provides a detailed description of the trends in male, and female formal, and informal sector participation during the economic reform period in Argentina, Brazil, and Costa Rica. The author first compares the gender composition of the formal, informal wage, and self-employment sectors in a year before reforms (1988 for Argentina, 1989 for Brazil, and Costa Rica), and a year after reforms implementation (1997 for Argentina, 1995 for Brazil and Costa Rica). Although women continued to be more likely than men to work in the informal wage sector, there is no trend of"masculinization"or"feminization"of the informal sector, or any other. Instead, in Argentina men have overtaken women as the most prevalent workers in the informal wage sector, while in Brazil, the opposite has occurred (as men move into self-employment). In Costa Rica there have been no statistical, observable changes. The author then considers the distribution across sectors within each gender group, to identify whether men, and women are more likely to select different sectors in the post-reform period relative to the pre-reform period. Among both men, and women in all three countries (except Brazilian men), workers have become more likely to hold informal wage jobs, and less likely to hold formal sector jobs. Trends in human capital accumulation explain these changes for both men, and women, while changes in gender roles, primarily in homecare and marriage, do not seem to have an effect.Health Monitoring&Evaluation,Labor Policies,Population&Development,Public Health Promotion,Environmental Economics&Policies,Health Monitoring&Evaluation,Environmental Economics&Policies,Population&Development,Banks&Banking Reform,Work&Working Conditions
NADPH-cytochrome P450 reductase is involved in flunitrazepam reductive metabolism in Hep G2 and Hep 3B cells.
No full textDetection of Penaeus monodon Baculovirus (MBV) mRNA in hepatopancreatic cells of the Penaeus monodon Fabricius by in situ hybridization.
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Fluorescence spectroscopy study of protoporphyrin IX in tissue-like phantoms
No full textFluorescence spectroscopy has been extensively investigated for disease diagnosis. In this framework, optical tissue phantoms are widely used for validating the biomedical device system in laboratory environment outside clinical procedures. Moreover, it is fundamental to consider that there are several scattering components and chromophores inside biological tissues and the interplay between scattering effects and absorption can result in a distortion of the emitted fluorescence signal. In this work, the photophysical behaviour of a set of liquid tissue like phantoms containing different compositions was analysed: phosphate buffer saline (PBS) was used as background medium, low fat milk as a scatterer, India ink as an absorber and PpIX dissolved in dimethyl formamide (DMF) as fluorophore. We examined the collected data in terms of the impact of surfactant Tween-20 on the background medium, scattering effects and combination of scattering and absorption within a luminescent body on PpIX. The results indicated that the intrinsic emission peaks are red-shifted by the scattering particles or surfactant, whilst the scatterer and absorber can alter the emission intensity substantially. We corroborated that phantoms containing higher surfactant content (> 0.5% Tween 20) are essential to prepare a stable aqueous phantoms
Discovery of a biomarker candidate for surgical stratification in high-grade serous ovarian cancer
No full textRNAseq_HH_clinical_ALG5 contains the gene expression (ALG5 NUP188 and GPR107) profiled by targeted RNA-seq and clinical data from the HH cohort;
eset_all_frma_combat_expr_9207_clinical_ALG5 contains the curated gene expression data and clinical data from the TTC cohort
The transcriptional activator Gli2 modulates T-cell receptor signalling through attenuation of AP-1 and NFκ-B activity.
Full text linkDifferent tissues contain diverse and dynamic cellular niches, providing distinct signals to tissue-resident or migratory, infiltrating immune cells. Hedgehog (Hh) proteins are secreted inter-cellular signalling molecules, which are essential during development and are important in cancer, post-natal tissue homeostasis and repair. Hh signalling, via the Hh-responsive transcription factor Gli2, also has multiple roles in T-lymphocyte development and differentiation. Here we investigate the function of Gli2 in T-cell signalling and activation. Gene transcription driven by the Gli2 transcriptional activator (Gli2A) attenuated T-cell activation and proliferation following T-cell receptor (TCR) stimulation. Expression of Gli2A in T-cells altered gene expression profiles, impaired the TCR-induced calcium flux and nuclear expression of NFAT, suppressed upregulation of molecules essential for activation, and attenuated signalling pathways upstream of AP-1 and NFκB, leading to reduced activation of these important transcription factors. Inhibition of physiological Hh-dependent transcription increased NFκB activity on TCR ligation. These data have importance for understanding molecular mechanisms of immunomodulation, particularly in tissues where Hh proteins or other Gli-activating ligands such as TGFβ are upregulated, including during inflammation, tissue damage and repair, or in tumour microenvironments
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