145,845 research outputs found
Lowe, D, 217806
No full textThis record was harvested from a previous catalogue system and will be withdrawn in 2025. Information in this record may be superseded or incomplete. Visit this record in UMA's new catalogue at: https://archives.library.unimelb.edu.au/nodes/view/400153Surname: LOWE. Given Name(s) or Initials: D. Military Service Number or Last Known Location: 217806. Missing, Wounded and Prisoner of War Enquiry Card Index Number: SEA-3736.218424
Item: [2016.0049.32446] "Lowe, D, 217806
Lowe, La D, QX2436
No full textThis record was harvested from a previous catalogue system and will be withdrawn in 2025. Information in this record may be superseded or incomplete. Visit this record in UMA's new catalogue at: https://archives.library.unimelb.edu.au/nodes/view/400171Surname: LOWE. Given Name(s) or Initials: LA D. Military Service Number or Last Known Location: QX2436. Missing, Wounded and Prisoner of War Enquiry Card Index Number: 8661.218442
Item: [2016.0049.32464] "Lowe, La D, QX2436
Family Therapy: a constructive framework
No full textFAMILY THERAPY: A CONSTRUCTIVE FRAMEWORK \ud
Roger Lowe\ud
\ud
Contents Page \ud
Acknowledgments viii\ud
Introduction 1\ud
1. Travelling Light 6\ud
2. Hosting Family Members 33\ud
3. Negotiating Concerns and Requests 54\ud
4. Clarifying 'Who Wants What?' 74\ud
5. Evoking Possibilities 97\ud
6. Working Constructively Over Time 123\ud
7. Using Inner Conversation 138\ud
8. Borrowing from Other Frameworks 153\ud
9. Responding to Challenges 175\ud
Final Reflections 204\ud
References 206\ud
Index 21
Lifecourse social position and D-dimer; findings from the 1958 British birth cohort
No full textThe aim is to examine the association of lifecourse socioeconomic position (SEP) on circulating levels of D-dimer. Data from the 1958 British birth cohort were used, social class was determined at three stages of respondents' life: at birth, at 23 and at 42 years. A cumulative indicator score of SEP (CIS) was calculated ranging from 0 (always in the highest social class) to 9 (always in the lowest social class). In men and women, associations were observed between CIS and D-dimer (P<0.05). Thus, the respondents in more disadvantaged social classes had elevated levels of D-dimer compared to respondents in less disadvantaged social class. In multivariate analyses, the association of disadvantaged social position with D-dimer was largely explained by fibrinogen, C-reactive protein and von Willebrand Factor in women, and additionally by smoking, alcohol consumption and physical activity in men. Socioeconomic circumstances across the lifecourse at various stages also contribute independently to raised levels of D-dimer in middle age in women only. Risk exposure related to SEP accumulates across life and contributes to raised levels of D-dimer. The association of haemostatic markers and social differences in health may be mediated by inflammatory and other markers
Personal Papers (MS 80-0002)
No full textLetter from I. H. Kempner to Hon. Sam D. W. Lowe discussing his appreciation for Christmas greetings and reciprocating with words of inspiration
Is rapid adaptive evolution important in successful invasions?
No full textEleanor E. Dormontt, Andrew J. Lowe and Peter J. Prenti
Study of the cell biological role of Lowe Syndrome protein OCRL1
No full textOculocerebrorenal syndrome of Lowe (OCRL) is caused by mutations in a
phosphatidylinositol 5-phosphatase, OCRL1, and is believed to lead to an
elevation of its preferred substrate, PI(4,5)P2. To date, much of the work on
OCRL1 has centred on its role at Golgi and endosomal membranes.
However, there is also evidence of plasma membrane activity for OCRL1,
where its PI(4,5)P2 substrate is known to be highly abundant. PI(4,5)P2
regulates a wide array of downstream cellular functions such as cytoskeletal
dynamics, membrane trafficking and signalling. The tight regulation of
PI(4,5)P2 levels and localisation, like other phosphoinositides, provides a
framework upon which many of these cellular processes work. In this thesis,
effects of OCRL1 loss have been tested through siRNA depletion of OCRL1,
focussing where possible on multiple PI(4,5)P2-dependent mechanisms, and
also focussing on cells forming polarised epithelia. Firstly, we have visualised
the localisation of PI(4,5)P2 in living HeLa cells lacking OCRL1 through
immunostaining for Annexin A2, which showed a marked translocation to the
plasma membrane. This change in distribution of Annexin A2 suggested that
OCRL1 depletion may have an effect on intracellular calcium dynamics as
well as PI(4,5)P2 localisation. We also used a GFP-chimera of the well
characterised PI(4,5)P2-binding pleckstrin homology domain of PLCδ1. This
showed no difference in localisation upon OCRL1 depletion. As OCRL1 is
highly enriched at the TGN, we fused the pleckstrin homology domain of
PLCδ1 to a mutated pleckstrin homology domain of OSBP known to bind ARF1 at the TGN, to act as a coincidence detector for PI(4,5)P2 at the TGN.
This construct also showed no reproducible effect of OCRL1 depletion.
Secondly we tested the effect of loss of OCRL1 on cytosolic calcium levels.
Using two phospholipase C (PLC) agonists, and a SERCA pump inhibitor, we
found no consistent differences in calcium handling upon depletion of OCRL1.
Thirdly, we have assessed the potential specialised role that OCRL1 has in
polarised epithelial cells, which might relate to the clinical picture in Lowe
Syndrome. We found that OCRL1 targets the tight junctions of immortalised
lines and primary cells. Through co-immunoprecipitation, we found OCRL1 in
complexes with the tight junction scaffold protein ZO-1. Most significantly, we
found that depletion of OCRL1 in human polarised epithelial cell lines
interfered with epithelial differentiation, reducing cell number and altering
morphology, to produce large flat cells. We attribute this phenotype, stronger
than any other so far described experimentally, to a defect in tight junction
maturation
Lowe, W. D. High School Yearbook 1967-1968
No full textYearbook of W. D. Lowe High School (Windsor, Ontario); formerly called Walkerville Technical School (and other names); yearbook also called the Towers.To view online at the Internet Archive: https://archive.org/details/lowe-19671968cropped/mode/2u
Lowe, W. D. High School Yearbook 1966-1967
No full textYearbook of W. D. Lowe High School (Windsor, Ontario); formerly called Walkerville Technical School (and other names); yearbook also called the Tower.To view online at the Internet Archive: https://archive.org/details/lowe-19661967croppe
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