1,391,383 research outputs found
Impaired neural development in a zebrafish model for lowe syndrome
No full textLowe syndrome, which is characterized by defects in the central nervous system, eyes and kidneys, is caused by mutation of the phosphoinositide 5-phosphatase OCRL1. The mechanisms by which loss of OCRL1 leads to the phenotypic manifestations of Lowe syndrome are currently unclear, in part, owing to the lack of an animal model that recapitulates the disease phenotype. Here, we describe a zebrafish model for Lowe syndrome using stable and transient suppression of OCRL1 expression. Deficiency of OCRL1, which is enriched in the brain, leads to neurological defects similar to those reported in Lowe syndrome patients, namely increased susceptibility to heat-induced seizures and cystic brain lesions. In OCRL1-deficient embryos, Akt signalling is reduced and there is both increased apoptosis and reduced proliferation, most strikingly in the neural tissue. Rescue experiments indicate that catalytic activity and binding to the vesicle coat protein clathrin are essential for OCRL1 function in these processes. Our results indicate a novel role for OCRL1 in neural development, and support a model whereby dysregulation of phosphoinositide metabolism and clathrin-mediated membrane traffic leads to the neurological symptoms of Lowe syndrome. © The Author 2011. Published by Oxford University Press. All rights reserved
Correspondence between Aziz Atiya and E. A. Lowe regarding an Arabic Sinai manuscript
No full text1. One-page typed letter, April 17, 1964, from Atiya to E. A. Lowe about a Sinai Arabic manuscript. 2. Two-page handwritten letter, Apr. 14, 1964, from E. A. Lowe to Atiya about a Sinai Arabic manuscript
Guidebook for Pre-conference North Island Field Trip A1 ‘Ashes to Issues’, 28-30 November, 2008
No full textWelcome to New Zealand or Aotearoa – „Land of the long lingering day [twilight]‟ – and to our three-day pre-conference North Island field trip „Ashes and Issues‟. We trust your stay in New Zealand is both informative and friendly and there is something for everyone on the trip. The itinerary in brief and a map of the North Island showing the main scientific stops are shown above. At the time of guidebook preparation, we have a group of 23, including four students, on the tour with participants from Japan, Taiwan, USA, UK, Australia and New Zealand. The tour leaders are Prof David Lowe (Univ. of Waikato, Hamilton) and Dr Haydon Jones (Scion Research, Rotorua). Assistant leader is Prof Paul McDaniel (Univ. of Idaho, Moscow), on leave at the Univ. of Waikato July-December, 2008. We offer a warm welcome to you all. Because we have considerable distances to travel (especially Day 3), as well as a range of stops planned, we will need to leave the hotel at 8.00 am each day
Old Friends
No full textContents: INTRODUCTION: How many Chinas are there? by Anna Chen p. 4; OLD FRIENDS by Hannah Lowe p. 8 ; IN CONVERSATION: with Hannah Lowe and Richard Scott p. 36; LIST OF ILLUSTRATIONS p. 42. Available to purchase at: https://www.herculeseditions.com/product-page/old-friends-by-hannah-lowe .Old Friends is an exploration of the first Chinatown – at Limehouse in London – a place far larger in the public imagination than the few streets that once homed foreign seamen. The poems in this chapbook ask what can be found between census figures and sensationalist portrayals, between Brilliant Chang and Fu Manchu, and how do these flickers of the past speak to present perceptions of China, a place continually imagined and re-imagined in Britain’s public conscious.Supported using public funding by Arts Council England (Lottery funded)
Steve Lowe Oral History Interview
No full textOral history interview with commercial fisherman Steve Lowe. Lowe has lived in Fort Pierce since 1938 and worked in the fishing industry for most of his life, as a fisherman and owner of a fish house, before retiring in 2006. He began fishing Oculina Bank in the 1950s and helped the Harbor Branch Oceanographic Institution locate the area in 1972. There were not many boats fishing the area then due to the tide, and all were commercial. When the area was closed to grouper and snapper fishing in 1994, Lowe stopped going there and compensated by targeting mostly kingfish. In Lowe\u27s opinion, quotas are the best way to manage a fishery, not closing species or areas. He thinks that the regulations have worked to put fishermen out of business. In this interview, Lowe also describes his fishing techniques and some of the equipment he used
I remember living at Seabrook, 1945-1953
No full textIn this "I remember" memoir, Ann Mariko Lowe recalls life at Seabrook, which introduced her to many new experiences, including Halloween traditions. She remembers the living conditions in the dorms at Seabrook, where there was little privacy, and poor facilities. Afterwards, her family moved to the apartments, where they were able to form close bonds with other Japanese families. This was especially helpful with expenses. Ann also played basketball at the Community Center, attended Bible study classes, and was a student at Seabrook School. The Seabrook Educational and Cultural Center has been soliciting current and past residents of Seabrook Farms for an "I remember" project. Residents are asked to create narratives regarding their experiences at Seabrook Farms. These memories help preserve the history and multi-cultural heritage of Seabrook Farms
Interview with Jane Lowe
No full textBorn and raised in Greensboro, North Carolina, Jane Lowe graduated from the Chapel Hill School of Nursing in 1959. In 1964, she moved to Wilmington with her husband, a German professor at UNCW. She began working part-time in the associate degree program for nursing as a clinical instructor at James Walker Hospital. When she was urged to become full-time faculty, she taught in the classroom as well, where she was known as a tough but dedicated educator. In her time at UNCW, Lowe witnessed the closing of James Walker Hospital and the addition of a baccalaureate degree program. She retired in 1999
Interview with Jane Lowe
No full textBorn and raised in Greensboro, North Carolina, Jane Lowe graduated from the Chapel Hill School of Nursing in 1959. In 1964, she moved to Wilmington with her husband, a German professor at UNCW. She began working part-time in the associate degree program for nursing as a clinical instructor at James Walker Hospital. When she was urged to become full-time faculty, she taught in the classroom as well, where she was known as a tough but dedicated educator. In her time at UNCW, Lowe witnessed the closing of James Walker Hospital and the addition of a baccalaureate degree program. She retired in 1999
Structure and function of the Lowe syndrome protein OCRL1
No full textOculocerebrorenal syndrome of Lowe (OCRL) is an X-linked disorder with the hallmark features of congenital cataracts, mental retardation and Fanconi syndrome of the kidney proximal tubules. OCRL was first described in 1952, and exactly four decades later, the gene responsible was identified and found to encode a protein highly homologous to inositol polyphosphate 5-phosphatase. This suggested that Lowe syndrome may represent an inborn error of inositol phosphate metabolism, and subsequent studies confirmed that such metabolism is indeed perturbed in Lowe syndrome cells. However, the mechanism by which loss of function of the OCRL1 protein brings about Lowe syndrome remains ill defined. In this review, I will discuss our understanding of OCRL1, including where it is localized, what it interacts with and what its possible functions might be. I will then discuss possible mechanisms by which loss of OCRL1 may bring about cellular defects that manifest themselves in the pathology of Lowe syndrome. Copyright © Blackwell Munksgaard 2005
Dorothy Lowe and Vern Broadwell on Nash automobile
No full textDorothy Lowe sits on the hood of a Nash automobile, while Vern Broadwell leans against the front of the car.https://dc.ewu.edu/lowe/1026/thumbnail.jp
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