120,666 research outputs found
Guidebook for Pre-conference North Island Field Trip A1 ‘Ashes to Issues’, 28-30 November, 2008
No full textWelcome to New Zealand or Aotearoa – „Land of the long lingering day [twilight]‟ – and to our three-day pre-conference North Island field trip „Ashes and Issues‟. We trust your stay in New Zealand is both informative and friendly and there is something for everyone on the trip. The itinerary in brief and a map of the North Island showing the main scientific stops are shown above. At the time of guidebook preparation, we have a group of 23, including four students, on the tour with participants from Japan, Taiwan, USA, UK, Australia and New Zealand. The tour leaders are Prof David Lowe (Univ. of Waikato, Hamilton) and Dr Haydon Jones (Scion Research, Rotorua). Assistant leader is Prof Paul McDaniel (Univ. of Idaho, Moscow), on leave at the Univ. of Waikato July-December, 2008. We offer a warm welcome to you all. Because we have considerable distances to travel (especially Day 3), as well as a range of stops planned, we will need to leave the hotel at 8.00 am each day
Lowe, V C, WX3888
No full textThis record was harvested from a previous catalogue system and will be withdrawn in 2025. Information in this record may be superseded or incomplete. Visit this record in UMA's new catalogue at: https://archives.library.unimelb.edu.au/nodes/view/400184Surname: LOWE. Given Name(s) or Initials: V C. Military Service Number or Last Known Location: WX3888. Missing, Wounded and Prisoner of War Enquiry Card Index Number: 44775.218455
Item: [2016.0049.32477] "Lowe, V C, WX3888
James V. Lowe, November 12, 1963
No full textPortrait of James Lowe seated in front of a patterned background. Written on verso: James V. Lowe; Photograph by Carl Van Vechten; 146 Central Park West; Cannot be reproduced without permission; November 12, 1963
V Block
No full textQuilt pattern from the Linda Lowe Quilt Patterns Collection titled V Block.https://scholarworks.moreheadstate.edu/lowe_quilt_patterns/1944/thumbnail.jp
James V. Lowe, November 12, 1963
No full textPortrait of James Lowe seated in front of a patterned background. Written on verso: James V. Lowe baritone and member of the music department at Fisk University; Photograph by Carl Van Vechten; 146 Central Park West; Cannot be reproduced without permission; November 12, 1963
Neobuthus awashensis Kovarik et Lowe 2012
No full textNeobuthus awashensis Kovařík et Lowe, 2012 (Figs. 1–6, 158, 161–165) Neobuthus awashensis Kovařík & Lowe, 2012: 7–16, figs. 5–6, 18–21, 34–38, 44–47, 67–74, 86, 89, 92, 95–96, 100–101; Kovařík et al., 2015: 30. TYPE LOCALITY AND TYPE REPOSITORY. Ethiopia, Awash, Metahara env., 08°54' N 39°54' E, 960-1050 m a.s.l., FKCP. TYPE MATERIAL. Ethiopia, Awash, Metahara env., 08°54' N 39°54' E, 960-1050 m a.s.l., 1♀ (paratype), 2008, leg. V. Trailin, 2♀1♀ im. (allotype and paratypes), XI.2010, leg. T. Mazuch and P. Novák, 32♂ (holotype and paratypes) 18♀ (paratypes) 11♀ ims, 5♂ ims (paratypes), 19.-22.VII.2011, leg. F. Kovařík. Most types are in the collection of the second author (FKCP), two paratypes (♂ ♀) are in the collection of the first author (GL). OTHER MATERIAL EXAMINED. Ethiopia, 11°43'22" N 40° 56'52" E, 457 m a.s.l. (Locality No. 12 EMA), 20.XI. 2012, 1♀1♀ im., leg. F. Kovařík (UV detection), FKCP; 11°43'30" N 40°58'45" E, 404 m a.s.l. (Locality No. 12EM), 20.XI.2012, 1♂, leg. F. Kovařík (UV detection), FKCP; Gewane, 10°09'38" N 40°39'45" E, 631 m a.s.l. (Locality No. 12 EO), 23.XI.2012, 1♂ 1♀, leg. F. Kovařík, (UV detection), FKCP; 09°08'10.4" N 40°09' 45.5" E, 835 m a.s.l. (Locality No. 12ER), 24.XI.2012, 12♂ 1♀ 1juv., leg. F. Kovařík (UV detection), FKCP, 26.-27.XI.2014, 8♂ 2♀ 2juvs, FKCP, 3♂ 2juvs, GL, leg. F. Kovařík; Awash, Metahara env., 08°54' N 39°54' E, 960-1050 m a.s.l. (Locality No. 12 EX), 25.XI.2012, 7♂ 6♀ 5juvs., 27.-30.XI.2014, 7♂ 1♀, topotypes, leg. F. Kovařík (UV detection), FKCP. EMENDED DIAGNOSIS. Total length 18–22 mm (males), 22.5–30 mm (females); carapace with area between anterior median carinae fuscous; tergites with fuscous pigmentation unbroken across median area; pedipalp relatively slender, males with femur L/ W 2.50 –2.70, patella L/ W 2.45 –2.70, chela L/ W 4.63 –5.08; chela movable finger with 5–6 subrows of primary denticles, 3–5 external accessory denticles flanking proximal end of each subrow; trichobothria d 2 usually absent from femur and patella; posterior margins of carapace and tergites usually bearing 2–4 macrosetae; pedipalps, legs, metasoma and telson with short, stout macrosetae in males, and long, fine setae in females; males with coxae sparsely granulated, sternites III–VI lightly shagreened to smooth, sternite VII finely granulated with 4 weak, granulated carinae; females with sternites III–VI smooth, sternite VII sparsely shagreened with 4 weak carinae, median carinae granulated; metasoma I–III with median lateral carinae present in both sexes; lateral surface of metasoma V in males densely granulated, with granules separated; soles of telotarsi with relatively sparse setation, leg III of adults with 6–9 macrosetae in retroinferior series of basitarsus, 12–19 ventral macrosetae on telotarsus; pectine teeth: 17–21 (males), 15–18 (females).Published as part of Lowe, Graeme & Kovařík, František, 2016, Scorpions of the Horn of Africa (Arachnida, Scorpiones). Part V. Two new species of Neobuthus Hirst, 1911 (Buthidae), from Ethiopia and Eritrea, pp. 1-46 in Euscorpius 224 on page
Study of the cell biological role of Lowe Syndrome protein OCRL1
No full textOculocerebrorenal syndrome of Lowe (OCRL) is caused by mutations in a
phosphatidylinositol 5-phosphatase, OCRL1, and is believed to lead to an
elevation of its preferred substrate, PI(4,5)P2. To date, much of the work on
OCRL1 has centred on its role at Golgi and endosomal membranes.
However, there is also evidence of plasma membrane activity for OCRL1,
where its PI(4,5)P2 substrate is known to be highly abundant. PI(4,5)P2
regulates a wide array of downstream cellular functions such as cytoskeletal
dynamics, membrane trafficking and signalling. The tight regulation of
PI(4,5)P2 levels and localisation, like other phosphoinositides, provides a
framework upon which many of these cellular processes work. In this thesis,
effects of OCRL1 loss have been tested through siRNA depletion of OCRL1,
focussing where possible on multiple PI(4,5)P2-dependent mechanisms, and
also focussing on cells forming polarised epithelia. Firstly, we have visualised
the localisation of PI(4,5)P2 in living HeLa cells lacking OCRL1 through
immunostaining for Annexin A2, which showed a marked translocation to the
plasma membrane. This change in distribution of Annexin A2 suggested that
OCRL1 depletion may have an effect on intracellular calcium dynamics as
well as PI(4,5)P2 localisation. We also used a GFP-chimera of the well
characterised PI(4,5)P2-binding pleckstrin homology domain of PLCδ1. This
showed no difference in localisation upon OCRL1 depletion. As OCRL1 is
highly enriched at the TGN, we fused the pleckstrin homology domain of
PLCδ1 to a mutated pleckstrin homology domain of OSBP known to bind ARF1 at the TGN, to act as a coincidence detector for PI(4,5)P2 at the TGN.
This construct also showed no reproducible effect of OCRL1 depletion.
Secondly we tested the effect of loss of OCRL1 on cytosolic calcium levels.
Using two phospholipase C (PLC) agonists, and a SERCA pump inhibitor, we
found no consistent differences in calcium handling upon depletion of OCRL1.
Thirdly, we have assessed the potential specialised role that OCRL1 has in
polarised epithelial cells, which might relate to the clinical picture in Lowe
Syndrome. We found that OCRL1 targets the tight junctions of immortalised
lines and primary cells. Through co-immunoprecipitation, we found OCRL1 in
complexes with the tight junction scaffold protein ZO-1. Most significantly, we
found that depletion of OCRL1 in human polarised epithelial cell lines
interfered with epithelial differentiation, reducing cell number and altering
morphology, to produce large flat cells. We attribute this phenotype, stronger
than any other so far described experimentally, to a defect in tight junction
maturation
Barbaracurus zambonellii Kovařík & Lowe & Šťáhlavský 2018, comb. n.
No full textBarbaracurus zambonellii (Borelli, 1902) comb. n. (Figures 7, 28, 36, 58–61, 79–80, 88–89, 219–244, 248– 251, 261–262, 265, Table 1) Babycurus zambonellii Borelli, 1902: 1–4; Hirst, 1907: 209; Kraepelin, 1913: 181; Caporiacco, 1947: 232; Probst, 1973: 329; Lamoral & Reynders, 1975: 498; Kovařík, 1998: 104 (in part); Fet & Lowe, 2000: 80 (in part); Lowe, 2000: 185–191 (in part); Kovařík, 2000: 260–261 (in part); Kovařík, 2003: 137 (? in part); Chiarle et al., 2012: 21. TYPE LOCALITY AND HOLOTYPE DEPOSITORY. Eritrea, Chenafena; MZUT. MATERIAL EXAMINED. Eritrea, Chenafena (14.786N 39.018E), 1♀ (holotype), MZUT; Filfil, Salamuna river, 15°36'34.6"N 38°57'22.8"E, 817 m a.s.l., 3.-4.XI.2015, (Figs. 224–225, Locality No. 15 EH), 3♂ 3♀1♀ im.3juvs. (No. 876, Figs. 28, 36, 219–223, 226–244, 258–251, 258–259), leg. F. Kovařík, FKCP. DIAGNOSIS. Total length of adult males 32–35 mm, adult females 46–52 mm. Coloration yellowish brown to grey with darker markings, chelicerae yellow without or with traces of reticulation. Pedipalp chela manus much wider in male than female, chela length/width ratio 3.42 in males and 4.29 in female; proximal margins of pedipalp fingers of female straight (Figs. 61, 231), of male undulate so as to leave a gap with fingers closed (Figs. 59, 233); dentate margin of movable finger armed with 7 rows of granules, and a short apical row of 3–4 denticles (Fig. 7); most proximal granule row with one external accessory granule. Pectines with 17–19 teeth in both sexes. Hemispermatophore basal lobe a weak, oblique carina (Figs. 28, 36). Metasoma narrow, metasoma V length/width ratio is 2.40–2.46 in males and 2.56–2.58 in females (Figs. 76–77); metasoma I with 10 carinae, II–IV with 8 carinae. Telson setose, bearing numerous long macrosetae and short, pointed subaculear tubercle; vesicle smooth, elongate, ellipsoidal, slightly bulbous, telson length/depth ratio 2.27–2.37 in both sexes; aculeus slender, curved, shorter than vesicle. NOTE. In his original description, Borelli (1902: 3) assumed that the holotype was a male, and this was accepted by most subsequent authors. Only Lowe (2000: 190–191) questioned this assumption, observing that the holotype exhibited some characters more consistent with females of other species of Babycurus sensu lato, and noted that “Study of additional material is needed to clarify variation and sexual dimorphism in B. zambonellii ”. Recently, the first author (F.K.) was able to finally settle this question by collecting additional material representing both sexes of B. zambonellii. The new specimens clearly demonstrated that the holotype is indeed female, not male. B. zambonellii is an Eritrean endemic and the female which Sissom (1994) cited from Yemen represents a new species which we describe here as B. yemenensis sp. n. COMMENTS ON LOCALITY AND LIFE STRATEGY. The first author (F.K.) visited the locality 15EH (Figs. 224–225), a montane, forested habitat along a riverbed of an occasional river, on 3–4 November 2015. At this locality, the author recorded a maximum daytime temperature of 30.3 ºC, and minimum nighttime temperatures of 19.6 ºC. The recorded humidity was between 46% and 92%. In addition to B. zambonellii the first author also recorded Hottentotta minax (L. Koch, 1875) at this locality.Published as part of Kovařík, František, Lowe, Graeme & Šťáhlavský, František, 2018, Review of the genus Babycurus Karsch, 1886 (Arachnida, Scorpiones, Buthidae), with descriptions of Barbaracurus gen. n. and two new species from Oman and Yemen, pp. 1-41 in Euscorpius 267 on pages 33-36, DOI: 10.5281/zenodo.654415
Richard Lowe
No full textMarietta High School students, studio portrait. Richard Lowe (Orian, v. 16, 1934, p. 45)
Marjorie Lowe
No full textMarietta High School students; studio portrait. Marjorie Lowe (Orian, v. 20, 1938, p. 46)
- …
