61 research outputs found
In Conversation with Steven Schweitzer, Reading Utopia in Chronicles (LHBOTS, 442; London: T. & T. Clark International, 2007)
No full textThis conversation with Steven Schweitzer, Reading Utopia in Chronicles (LHBOTS, 442; London: T. & T. Clark International, 2008) began in a special session of the Chronicles-Ezra-Nehemiah Section of the Society of Biblical Literature held at the SBL annual meeting in November 2007 in San Diego, California. It includes an introduction by the editor and two contributions, one by the editor and Matthew Forrest Lowe and another by Roland Boer, and concludes with a response by Steven Schweitzer.</jats:p
Review of Eidevall, Göran, Prophecy and Propaganda: Images of Enemies in the Book of Isaiah (Coniectanea Biblica: Old Testament Series, 56; Winona Lake, Ind.: Eisenbrauns, 2009).
No full text
Understanding the role of interleukin-8 (IL-8) in canine osteosarcoma metastasis
No full textThe student, Matthew Dowling, accepted the attached license on 2018-06-20 at 22:06.The student, Matthew Dowling, submitted this Thesis for approval on 2018-06-20 at 22:14.This Thesis was approved for publication on 2018-06-22 at 14:38.DSpace SAF Submission Ingestion Package generated from Vireo submission #12656 on 2018-09-27 at 11:16:08Made available in DSpace on 2018-09-27T16:30:14Z (GMT). No. of bitstreams: 2
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Previous issue date: 2018-06-22Embargo set by: Seth Robbins for item 107754
Lift date: 2020-09-27T16:30:34Z
Reason: Author requested U of Illinois access only (OA after 2yrs) in Vireo ETD systemEmbargo set by: Seth Robbins for item 107754
Lift date: 2020-09-27T16:31:43Z
Reason: Author requested U of Illinois access only (OA after 2yrs) in Vireo ETD systemEmbargo set by: Seth Robbins for item 107754
Lift date: 2020-09-27T16:34:29Z
Reason: Author requested U of Illinois access only (OA after 2yrs) in Vireo ETD systemInterleukin-8 (IL-8) is a chemokine whose primary function is to regulate neutrophil chemotaxis and modulate the inflammatory response in normal physiologic conditions. Additionally, IL-8 appears to play an important role in tumorigenesis and metastasis in vitro and in vivo in human solid tumors. There is growing evidence to suggest that IL-8 can serve as a biomarker for patients with cancer, with high IL-8 levels often correlated with advanced stage disease, metastasis, and poorer overall outcome. Though IL-8 appears to be intimately associated with cancer progression and metastasis in human, the role of IL-8 in veterinary oncology is largely unexplored.
Osteosarcoma (OS) is a common, naturally-occurring, highly metastatic cancer in dogs that serves as an excellent model for the disease in people. Recent comparative genomics indicate that IL-8 expression is conserved in both human and canine OS and is a negative prognostic indicator in people with this cancer. Therefore, understanding how IL-8 impacts disease progression, specifically in regards to the development of metastasis, could help us more effectively manage OS in both dogs and people.
In this study, we hypothesized 1) that canine OS cells will express IL-8 and its cognate receptors, CXCR1 and CXCR2, 2) that inhibition of IL-8 signaling will attenuate proliferation and migration, 3) that inhibition of IL-8 signaling will enhance sensitivity to cytotoxic agents, and 4) that IL-8 signaling will influence the expression of genes involved necessary for angiogenesis.
We investigated CXCR1 and CXCR2 gene transcription with qualitative polymerase chain reaction (PCR), and we investigated protein expression for IL-8, CXCR1, and CXCR2 with Western blotting. We evaluated OS cell production of IL-8 with an ELISA. We employed a competitive CXCR1/CXCR2 antagonist (Reparixin), as well as an IL-8 neutralizing monoclonal antibody (mAb), to mitigate IL-8 signaling in cell lines. Fluorescent cellular metabolic assays were used to determine the effects of manipulation of the IL-8 signaling axis on cellular proliferation and on chemosensitization to a platinum chemotherapeutic (carboplatin). Scratch assays were used to assess cellular migration following exposure to one of the IL-8 inhibitory agents. Quantitative PCR was again used to evaluate the gene transcription of VEGF in OS cell lines and a canine endothelial cell line following manipulation of the IL-8 signaling axis.
Gene transcription of the IL-8 receptors was noted in six OS cell lines. Furthermore, we were able to demonstrate protein expression of IL-8 in all cell lines. IL-8 was produced in a cell density-dependent manner in all cell lines examined. We showed that the addition of exogenous IL-8 led to a dose-dependent increase in proliferation in an OS cell line that was a low producer of IL-8. IL-8 receptor blockade appeared to have no impact on proliferation at the doses examined. IL-8 receptor blockade also did not enhance sensitivity to carboplatin in vitro. However, receptor blockade did appear to inhibit migration in a dose-dependent manner in the low-producer of IL-8. IL-8 neutralization with a mAb had not effect on proliferation, migration, or chemosensitization. We were also able to show that addition of IL-8 increased VEGF gene transcription.
These findings suggest that autocrine/paracrine IL-8 signaling may be more important in promoting a more metastatic cellular phenotype in those OS cells that are low-producers of this chemokine. Additionally, our results suggest that IL-8 likely plays a role in cultivating a pro-angiogenic tumor microenvironment.Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2020-08-01U of I Only Restriction Lifted for Item 107754 on 2020-09-28T09:15:07Z
Additional file 1 of Diagnostic delay of myositis: an integrated systematic review
No full textAdditional file 1. Supplementary table 1. Search string conducted on Pubmed/Medline. Supplementary table 2. Data extraction tool. Supplementary table 3. Adapted version of Newcastle-Ottawa score. Supplementary table 4. Data extraction summary of selected studies. Supplementary table 5. Meta-aggregation results of initial symptoms by subtypes of IIM. Factors identified in case studies as related to diagnostic delay. Supplementary table 6. Factors identified in case studies as related to diagnostic delay. Supplementary table 7. Factors of diagnostic delay by myositis types. Supplementary figure 1. Adapted version of Newcastle-Ottawa score. Supplementary figure 2. Contour-Enhanced funnel plot for mean diagnostic delay in diagnosis (n = 19). Supplementary figure 3. Forrest plot for mean diagnostic delay in all studies reporting standard deviation (no = SD not estimated, yes = SD estimated). Supplementary figure 4. Forrest plot for mean diagnostic delay in MSA tested and not tested studies. Supplementary figure 5. forrest plot for mean diagnostic delay in Peter Bohan's criteria and ENMC criteria. Supplementary figure 6. Forrest plot for mean diagnostic delay in multidisciplinary and specialist centres. Review protocol: Diagnostic delay of myositis: a protocol of an integrated systematic review
Reading acts of narrative appropriation: four instances of fraudulent memoir
No full textPhDThis thesis examines acts of narrative appropriation, the telling of purportedly‘authentic’ life stories by those for whom the stories are not theirs to tell. This
misuse or subversion of genre - the discipline of historical writing and the category
of autobiography - becomes a means for cultural, social and political dissimulation,
and the analysis focuses both on the act: the event, trespass, or ‘theft’ of another’s
life story, and on the cultural meaning that this event reveals. These narrative acts
are approached theoretically through discussions of what it means to be an author, a
reader, and through the consideration of literary and social genre, category and form.
In exploring identities at particular risk of appropriation, this thesis shows how
fraudulent appropriated narratives affect our reading of the world, and in turn
influence our perception of already marginalized social groups. My primary
examples include prostitution ‘narratives’, Native North American ‘memoir,’ and
fraudulent Holocaust survivor ‘testimony,’ with each text providing decoded
evidence of ‘genre-bending’ exhibiting a social and political intent. These works
seek to be read as authentic personal narratives, as autobiography, and that is how
they have been presented to the reader. However, they are imposters – fictional tales
desiring the elevated status of historical authenticity and willing to bend the rules
and contracts of genre to achieve their end. Here the appearance of authenticity is
achieved through the use of cultural and social ‘myth,’ or perceptions of cultural
identity, and as such its fraudulent construction is first and foremost a social act,
with a social and economic motivation. As this thesis concludes, these texts are
most successful when their own political and social ideologies echo and confirm that
of the readership; when their subjects, the fraudulent ‘I’ at the center of the text is
also a performative elaboration of cultural belief
ALT-C 2011 Abstracts
No full textThis is a PDF of the abstracts for all the sessions at the 2011 ALT conference. It is designed to be used alongside the online version of the conference programme. It was made public on 1 September, with a "topped and tailed" made live on 2 September
Renaissance humanism and John Merbecke's - The booke of Common praier noted (1550)
No full textRenaissance humanism was an intellectual technique which contributed most to the origin and development of the Reformation. While the relation of Renaissance humanism and the Reformation is of considerable interest in the realms of history and theology, it has seldom been examined from a musicological perspective. This study aims to fill that gap by elucidating the way humanist musical thought influenced Reformation attitudes to music, with particular reference to the sixteenth-century reform of plainchant. The focus of the study is on the musical manifestation of the English Reformation, The booke of Common praier noted (BCPN, 1550) by John Merbecke (c.1505 - C.1585). Drawing upon issues of the interpretation of Renaissance humanism and its relation to the Reformation, the thesis challenges existing understandings of Merbecke and his music. Chapter one is a biographical study to re-appraise Merbecke's careers and outlooks in the light of Renaissance humanism, especially of Erasmian lines. It serves as a starting point for re-evaluating the significance of BCPN in relation to humanist musical thought. Chapter two explores the musical framework of Erasmian humanism which became a major intellectual basis for the renewal of Christian music on the eve of the Reformation. Chapter three reveals the core of Anglican plainchant apologetics underlying BCPN, illustrating that the musico- rhetorical and ethical associations of humanism played an integral part in shaping the Anglican criteria of true ecclesiastical music. Chapter four argues that two humanist conceptions were integrated into the programme of the reform of plainchant in BCPN: 'rhetorical theology' (theologia rhetorica) and 'rhetorical music' (musica rhetorica). It explores word-tone relations in BCPN, thereby demonstrating its characteristics as a humanist plainchant directed towards the 'rhetoricisation of music'; it sheds a new light upon Merbecke's notation and modes in BCPN, especially in relation to the ‘theory of accented singing' and the doctrine of 'mode ethos’
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