89 research outputs found
Creation and composition of a songbook of children's routines as a resource for the teacher of Music aimed at primary school children
No full textTítulo: Creación y composición de un cancionero de rutinas infantiles como recurso didáctico para
el docente de música orientado a niños de básica primaria.
Autor(es): Daniela Macareo Velásquez, Francy Gabriela Zambrano Pereira.
Palabras Clave: Rutina, composición, cancionero, docente, niños, básica primaria.
Descripción: Este proyecto de grado está enfocado principalmente en la creación y composición
de un cancionero de rutinas infantiles como un recurso valioso para el docente de música y una
ventaja de aprendizaje para los estudiantes en el aula de clase, creando, de esta manera, una forma
nueva para que el estudiante vea sus rutinas diarias mucho más atractivas por medio de la música,
las canciones y el trabajo en grupo.PregradoLicenciado en MúsicaTitle: Creation and composition of a songbook of children's routines as a didactic resource for the
music teacher oriented to elementary school children.
Author(s): Daniela Macareo Velásquez, Francy Gabriela Zambrano Pereira.
Key Words: Routine, composition, songbook, teacher, children, elementary school.
Description: This degree work focuses primarily on the creation and composition of a songbook
of children's routines as a valuable resource for the music teacher and a learning advantage for
students in the classroom, thus creating a new way for the student sees his daily routines become
much more attractive through music, songs and group work
Speroni, Sperone
No full textThe Paduan philosopher and man of letters Sperone Speroni degli Alvarotti (1500–1588) was one of the most prominent cultural figures of sixteenth-century Italy who had a pivotal role in the vernacularization and dissemination of the works of Aristotle (Sperone Speroni 1989; Fournel 1989; Panciera 2010–2011; Vianello 2011). He spent his whole, unsettled life writing especially dialogues, orations, let- ters, and discourses on the most diverse topics, such as love, ethics, politics, history, language, and rhetoric (Ms. E/13; Dalle Laste and Forcellini 1740; Loi and Pozzi 1993). He was the author of a highly polemical play, the Canace et Macareo [Canace et Macareo], writ- ten in Padua in 1542 and printed in Florence four years later (Roaf 1982). Formerly a uni- versity professor and philosopher (he was a pupil of Pietro Pomponazzi), then a rhetorician and a vulgarizer in the academies, and finally a courtier, Speroni was closely involved in Padua’s Accademia degli Infiammati (Academy of the Burning Ones). His works deeply influenced several protagonists of the Renaissance culture, even beyond Italy, although only in recent years scholars have been giving this figure the attention he deserves
Emerg Infect Dis
No full textDuring 2013-2016, we isolated blaNDM- and blaVIM-harboring Enterobacteriaceae and nonfermentative bacteria from patients in the Philippines. Of 130 carbapenem-resistant isolates tested, 45 were Carba NP-positive; 43 harbored blaNDM, and 2 harbored blaVIM. Multidrug-resistant microbial pathogen surveillance and antimicrobial drug stewardship are needed to prevent further spread of New Delhi metallo-\u3b2-lactamase variants
Development of an adjuvanted nanoparticle vaccine against influenza virus, an in vitro study.
No full textInfluenza is an infectious respiratory illness caused by influenza viruses. Despite yearly updates, the efficacy of influenza vaccines is significantly curtailed by the virus antigenic drift and antigenic shift. These constant changes to the influenza virus make-up also challenge the development of a universal flu vaccine, which requires conserved antigenic regions shared by influenza viruses of different subtypes. We propose that it is possible to bypass these challenges by the development of an influenza vaccine based on conserved proteins delivered in an adjuvanted nanoparticle system. In this study, we generated influenza nanoparticle constructs using trimethyl chitosan nanoparticles (TMC nPs) as the carrier of recombinant influenza hemagglutinin subunit 2 (HA2) and nucleoprotein (NP). The purified HA2 and NP recombinant proteins were encapsulated into TMC nPs to form HA2-TMC nPs and NP-TMC nPs, respectively. Primary human intranasal epithelium cells (HNEpCs) were used as an in vitro model to measure immunity responses. HA2-TMC nPs, NP-TMC nPs, and HA2-NP-TMC nPs (influenza nanoparticle constructs) showed no toxicity in HNEpCs. The loading efficiency of HA2 and NP into the TMC nPs was 97.9% and 98.5%, respectively. HA2-TMC nPs and NP-TMC nPs more efficiently delivered HA2 and NP proteins to HNEpCs than soluble HA2 and NP proteins alone. The induction of various cytokines and chemokines was more evident in influenza nanoparticle construct-treated HNEpCs than in soluble protein-treated HNEpCs. In addition, soluble factors secreted by influenza nanoparticle construct-treated HNEpCs significantly induced MoDCs maturation markers (CD80, CD83, CD86 and HLA-DR), as compared to soluble factors secreted by protein-treated HNEpCs. HNEpCs treated with the influenza nanoparticle constructs significantly reduced influenza virus replication in an in vitro challenge assay. The results indicate that TMC nPs can be used as influenza vaccine adjuvants and carriers capable of delivering HA2 and NP proteins to HNEpCs
Triangular test design to evaluate tinidazole in the prevention of Plasmodium vivax relapse.
No full textBACKGROUND: There are very few drugs that prevent the relapse of Plasmodium vivax malaria in man. Tinidazole is a 5-nitroimidazole approved in the USA for the treatment of indications including amoebiasis and giardiasis. In the non-human primate relapsing Plasmodium cynomolgi/macaque malaria model, tinidazole cured one of six macaques studied with an apparent mild delay to relapse in the other five of 14-28 days compared to 11-12 days in controls. One study has demonstrated activity against P. vivax in man. Presented here are the results of a pilot phase II, randomized, open-label study conducted along the Thai-Myanmar border designed to evaluate the efficacy of tinidazole to prevent relapse of P. vivax when administered with chloroquine. METHODS: This study utilized a modified triangular test sequential analysis which allows repeated statistical evaluation during the course of enrolment while maintaining a specified power and type 1 error and minimizing recruitment of subjects. Enrolment was to be halted when a pre-specified success/failure ratio was surpassed. The study was designed to have a 5% type 1 error and 90% power to show whether tinidazole would produce a relapse rate of less than 20% or greater than 45% through Day 63 of weekly follow-up after initiation of treatment and initial parasite clearance with 3 days of an oral weight based dosing of chloroquine and five days of 2 grams/day of tinidazole. RESULTS: All subjects cleared their parasitaemia by Day 3. Six of the first seven subjects treated with tinidazole relapsed prior to Day 63 (average Day 48.3 (range 42-56)). This exceeded the upper boundary of the triangular test and enrolment to receive tinidazole was halted. A concurrent cohort of five subjects definitively treated with standard doses of primaquine and chloroquine (historically 100% effective) showed no episodes of recurrent P. vivax parasitaemia during the 63-day protocol specified follow-up period. CONCLUSIONS: Tinidazole is ineffective in preventing relapse of P. vivax at the dose used. The macaque relapsing model appeared to correctly predict outcome in humans. Use of the modified triangular test allowed minimal enrolment and limited unnecessary exposure to the study drug and reduced costs. This adds weight to the ethical and economic advantages of this study design to evaluate similarly situated drugs. TRIAL REGISTRATION: ClinicalTrials.gov NCT00811096
Use of structural equation models to predict dengue illness phenotype
No full textBACKGROUND: Early recognition of dengue, particularly patients at risk for plasma leakage, is important to clinical management. The objective of this study was to build predictive models for dengue, dengue hemorrhagic fever (DHF), and dengue shock syndrome (DSS) using structural equation modelling (SEM), a statistical method that evaluates mechanistic pathways. METHODS/FINDINGS: We performed SEM using data from 257 Thai children enrolled within 72 h of febrile illness onset, 156 with dengue and 101 with non-dengue febrile illnesses. Models for dengue, DHF, and DSS were developed based on data obtained three and one day(s) prior to fever resolution (fever days -3 and -1, respectively). Models were validated using data from 897 subjects who were not used for model development. Predictors for dengue and DSS included age, tourniquet test, aspartate aminotransferase, and white blood cell, % lymphocytes, and platelet counts. Predictors for DHF included age, aspartate aminotransferase, hematocrit, tourniquet test, and white blood cell and platelet counts. The models showed good predictive performances in the validation set, with area under the receiver operating characteristic curves (AUC) at fever day -3 of 0.84, 0.67, and 0.70 for prediction of dengue, DHF, and DSS, respectively. Predictive performance was comparable using data based on the timing relative to enrollment or illness onset, and improved closer to the critical phase (AUC 0.73 to 0.94, 0.61 to 0.93, and 0.70 to 0.96 for dengue, DHF, and DSS, respectively). CONCLUSIONS: Predictive models developed using SEM have potential use in guiding clinical management of suspected dengue prior to the critical phase of illness
Use of structural equation models to predict dengue illness phenotype
No full textBackgroundEarly recognition of dengue, particularly patients at risk for plasma leakage, is important to clinical management. The objective of this study was to build predictive models for dengue, dengue hemorrhagic fever (DHF), and dengue shock syndrome (DSS) using structural equation modelling (SEM), a statistical method that evaluates mechanistic pathways.Methods/FindingsWe performed SEM using data from 257 Thai children enrolled within 72 h of febrile illness onset, 156 with dengue and 101 with non-dengue febrile illnesses. Models for dengue, DHF, and DSS were developed based on data obtained three and one day(s) prior to fever resolution (fever days -3 and -1, respectively). Models were validated using data from 897 subjects who were not used for model development. Predictors for dengue and DSS included age, tourniquet test, aspartate aminotransferase, and white blood cell, % lymphocytes, and platelet counts. Predictors for DHF included age, aspartate aminotransferase, hematocrit, tourniquet test, and white blood cell and platelet counts. The models showed good predictive performances in the validation set, with area under the receiver operating characteristic curves (AUC) at fever day -3 of 0.84, 0.67, and 0.70 for prediction of dengue, DHF, and DSS, respectively. Predictive performance was comparable using data based on the timing relative to enrollment or illness onset, and improved closer to the critical phase (AUC 0.73 to 0.94, 0.61 to 0.93, and 0.70 to 0.96 for dengue, DHF, and DSS, respectively).ConclusionsPredictive models developed using SEM have potential use in guiding clinical management of suspected dengue prior to the critical phase of illness.</div
- …
