10 research outputs found
sj-docx-1-mso-10.1177_20552173231201422 - Supplemental material for Does the Multiple Sclerosis Impact Scale-29 (MSIS-29) have the range to capture the experience of fully ambulatory multiple sclerosis patients? Learnings from the ASCLEPIOS studies
No full textSupplemental material, sj-docx-1-mso-10.1177_20552173231201422 for Does the Multiple Sclerosis Impact Scale-29 (MSIS-29) have the range to capture the experience of fully ambulatory multiple sclerosis patients? Learnings from the ASCLEPIOS studies by Antoine Regnault, Angely Loubert, Róisín Brennan, Juliette Meunier, Christel Naujoks, Stefan Cano and Nicholas Adlard in Multiple Sclerosis Journal – Experimental, Translational and Clinical</p
Feminismus a mytopoetika v dílech Angely Carterové Krvavá komnata a Noci v cirkuse
No full textCílem této práce je představit specifické pojetí feminismu a mytopoetiky Angely Carterové a demonstrovat je na jejích dvou vybraných dílech, jmenovitě na sbírce subverzivně zpracovaných tradičních pohádek Krvavá komnata a jiné pohádky a na románu Noci v cirkuse. Práce se také zabývá vybranými rysy postmodernismu obsažených v těchto dvou dílech. V první, teoretické části je představena autorka a její dílo, dále pak koncept postmodernismu a jeho vybrané jednotlivé rysy. Druhá, praktická část se zaměřuje na analýzu obou knih s cílem zjistit, zda a jakým způsobem tato díla vykazují rysy postmodernismu a do jaké míry lze ve vybraných knihách myšlenky feminismu a mytopoetiky Angely Carterové nalézt.The aim of this thesis is to present the specific notion of feminism and mythopoetics in the selected works of Angela Carter and demonstrate them on two selected works of Carter's, namely on the collection of re-visited traditional fairy tales The Bloody Chamber and Other Stories and the novel Nights at the Circus. The thesis also deals with chosen features of postmodernism these two works contain. In the first, theoretical part the author and her oeuvre is introduced, followed by the concept of postmodernism and its selected features. The second, practical part is focused on both books' analysis which attempts to establish whether and how the selected works show the features of postmodernism and to which extent it is possible to trace the notions of Carter's feminism and mythopoetics in them.Katedra anglického jazyka a literaturyFaculty of EducationPedagogická fakult
Dramaturgia Acusmática
No full textIlustraciones, figurasEste trabajo propone una metodología de investigación-creación que entrelaza la acusmática con la dramaturgia, estableciendo un diálogo multidisciplinario basado en diversas áreas del conocimiento. A lo largo de la investigación, la autora recoge y analiza un considerable conjunto de relatos que ilustran las memorias de la infancia en el contexto del conflicto armado en Colombia, abordando la violencia desde una perspectiva poética y crítica.
El estado del arte de este trabajo se fundamenta en interacciones con múltiples autores y materiales expresivos, evidenciando los referentes artísticos que conforman la obra. La autora enfatiza la importancia de realizar memoria en un contexto donde el arte se convierte en un mecanismo de reparación simbólica, dando visibilidad a la niñez afectada por la violencia y el abandono institucional. Su análisis se centra en la relación de los sonidos con las memorias, resaltando cómo la violencia del territorio enmascara las violencias intrafamiliares.
La metodología de investigación-creación en este trabajo, denominada dramaturgia acusmática, se distingue por la transformación de interpretaciones artísticas en mecanismos dramatúrgicos que construyen narrativas a través del sonido, enmascarando una realidad del campesinado colombiano. La autora enfrenta la tradición académica al incorporar un formato de escritura epistolar que refleja sus indagaciones teóricas de manera no convencional. A través de conceptos como el "fósil sonoro" y el "cocktail party effect", su propuesta aporta al diálogo sobre la creación dramatúrgica contemporánea al trascender la autoficción y autorreferencialidad, dirigiendo la atención hacia la construcción de un relato que trasciende lo individual y se vuelve colectivo.
Frente a la realidad del post-acuerdo en Colombia, el trabajo no solo documenta un lacerante retrato de la cotidianidad en contextos de conflicto, sino que también insta a reflexionar sobre el dolor de generaciones afectadas. En conclusión, la propuesta metodológica de la autora representa un aporte al campo de la escritura creativa, retando las normas tradicionales y abriendo nuevas posibilidades de exploración en el arte y la producción de conocimiento.This work proposes a research-creation methodology that intertwines acousmatics with dramaturgy, establishing a multidisciplinary dialogue based on various areas of knowledge. Throughout the research, the author collects and analyzes a considerable set of stories that illustrate childhood memories in the context of the armed conflict in Colombia, addressing violence from a poetic and critical perspective.
The state of the art of this work is based on interactions with multiple authors and expressive materials, highlighting the artistic references that make up the work. The author emphasizes the importance of creating memory in a context where art becomes a mechanism of symbolic reparation, giving visibility to children affected by violence and institutional abandonment. Her analysis focuses on the relationship between sounds and memories, highlighting how the violence of the territory masks intra-family violence.
The research-creation methodology in this work, called acousmatic dramaturgy, is distinguished by the transformation of artistic interpretations into dramaturgical mechanisms that construct narratives through sound, masking a reality of the Colombian peasantry. The author confronts academic tradition by incorporating an epistolary writing format that reflects her theoretical inquiries in an unconventional way. Through concepts such as the "sound fossil" and the "cocktail party effect", her proposal contributes to the dialogue on contemporary dramaturgical creation by transcending autofiction and self-referentiality, directing attention towards the construction of a story that transcends the individual and becomes collective.
Faced with the reality of the post-agreement in Colombia, the work not only documents a lacerating portrait of everyday life in contexts of conflict, but also encourages reflection on the pain of affected generations. In conclusion, the author's methodological proposal represents a contribution to the field of creative writing, challenging traditional norms and opening up new possibilities for exploration in art and the production of knowledge.MaestríaMagister en Arte
O cinema e o uso de ferramentas digitais para a apropriação dos direitos humanos em sala de aula
No full textEl cine como representación social implica el uso de múltiples elementos de comunicación que, a su vez, posibilita abordar temas diversos que pueden tocar la cotidianidad, imaginación y emocionalidad de los participantes, es por ello que puede convertirse en una excelente herramienta para la educación en el área de sociales, su inclusión para el manejo de temas como derechos humanos es invaluable. El cine, además, genera en los estudiantes creatividad, reflexión y un pensamiento crítico, que finalmente contribuyen en el proceso formativo.En el aula el cine puede utilizarse ya sea como material de trabajo o plantearse la creación de videos para la expresión de diversas temáticas y situaciones cotidianas cercanas al estudiante, en cualquier caso, la imagen y el sonido pueden aportar en la construcción de saberes, en la expresión de emociones e incluso en la resolución de conflictos en el aula. Ahora bien, en un gran número de instituciones educativas se presentan conflictos que afectan el día a día en el aula, algunos problemas incluso desencadenan en violencia escolar, es por ello, que la búsqueda de iniciativas y propuestas para mitigar estas situaciones es apremiante.En este contexto, herramientas como el cine y el video pueden incorporarse en el aula para apoyar la apropiación de los derechos humanos, tema que puede tener gran incidencia en la mitigación de conflictos. En este artículo se muestra una reflexión respecto a la temática desde la vivencia del autorCinema as a social representation implies the use of multiple elements of communication that, in turn, makes it possible to address various topics that can touch the daily life, imagination and emotionality of the participants, which is why it can become an excellent tool for education in the area of social studies, its inclusion for the management of issues such as human rights is invaluable. Cinema also generates creativity, reflection and critical thinking in students, which ultimately contribute to the educational process. In the classroom, films can be used either as work material or for the creation of videos for the expression of various topics and everyday situations close to the student, in any case, the image and sound can contribute to the construction of knowledge, in the expression of emotions and even in the resolution of conflicts in the classroom. However, in a large number of educational institutions there are conflicts that affect the daily life in the classroom, some problems even lead to school violence, which is why the search for initiatives and proposals to mitigate these situations is urgent. In this context, tools such as film and video can be incorporated in the classroom to support the appropriation of human rights, a topic that can have a great impact on conflict mitigation. This article presents a reflection on the subject from the author\u27s own experience.O cinema como representação social envolve a utilização de múltiplos elementos de comunicação que, por sua vez, permitem abordar diversos temas que podem tocar o quotidiano, a imaginação e a emotividade dos participantes, razão pela qual pode tornar-se uma excelente ferramenta para a educação em na área social, a sua inclusão na gestão de questões como os direitos humanos é inestimável. O cinema também gera criatividade, reflexão e pensamento crítico nos alunos, o que acaba por contribuir para o processo educativo. Na sala de aula, o cinema pode ser utilizado quer como material de trabalho, quer a criação de vídeos pode ser considerada para expressar diversos temas e situações do quotidiano próximos do aluno. Em qualquer caso, a imagem e o som podem contribuir para a construção do conhecimento, na expressão das emoções e até na resolução de conflitos em sala de aula. Agora, em um grande número de instituições de ensino surgem conflitos que afetam o cotidiano em sala de aula, alguns problemas até desencadeiam a violência escolar, por isso é urgente a busca por iniciativas e propostas para mitigar essas situações. Neste contexto, ferramentas como o filme e o vídeo podem ser incorporadas na sala de aula para apoiar a apropriação dos direitos humanos, uma questão que pode ter um grande impacto na mitigação de conflitos. Este artigo apresenta uma reflexão sobre o tema a partir da experiência do autor.
Horizontální přímý účinek základních svobod
No full textv slovenskom jazyku: Vyjadrenie Angely Merkelovej z novembra 2014, že by radšej videla EU bez Veľkej Británie ako kompromitovala voľný pohyb v EU (ktoré sa nakoniec do dňa uzavretia rukopisu tejto práce zhmotnilo v potenciálne vystúpenie Veľkej Británie z EU) bolo jedným z motívov, ktoré primäli autorku k tomu, aby vo svojej práci analyzovala dosah pravidiel upravujúcich voľný pohyb, konkrétne horizontálny priamy účinok slobôd voľného pohybu. Autorka sa v práci zameriava na otázky vyplývajúce zo širšej problematiky legitimity integrácie európskeho trhu, ktoré premietla do konceptu rozdelenia legislatívnych (a širšie povedané regulačných) právomocí medzi EU a členskými štátmi a z toho vyplývajúceho rozdelenia medzi adresátmi jednotlivých ustanovení Zmluvy, teda členskými štátmi a súkromnými subjektmi. Táto práca sa teda zaoberá nasledujúcou otázkou: Do akej miery sa podarilo SDEU rozšíriť európsku integráciu prostredníctvom rozvinutia princípu horizontálneho priameho účinku slobôd voľného pohybu? Podľa tradičného vnímania prevládajúceho po založení Európskeho hospodárskeho spoločenstva boli jedinými adresátmi ustanovení upravujúcich voľný pohyb v rámci EU členské štáty a súkromným osobám mohli vznikať povinnosti len na podklade európskeho súťažného práva. Avšak ako vyplýva z analýzy obsiahnutej v...in English language: The statement of Angela Merkel from November 2014 that she would rather see the UK out of the EU than compromise the free movement in the EU (which as at the date of the submission of this dissertation materialized in potential Brexit) was one of the reasons which encouraged the author to analyse the reach of free movement rules, more specifically the horizontal direct effect of the Treaty freedoms, in this dissertation. The author focuses on the issues stemming mainly from the broader topic of the legitimacy of market integration which the author translated into the concept of separation of the regulatory competences between the EU and the Member States and related separation between the Treaty provisions' addressees, namely the Member States and the private entities. This dissertation focuses on the following research question: To what extent has the CJEU advanced the European market integration through the development of the principle of horizontal direct effect of the Treaty freedoms? The starting point after the establishment of the EEC was that the sole addressees of the Treaty freedoms were the Member States whereas the Treaty rules on competition only applied to private entities. However, as is demonstrated throughout this dissertation, it is nowadays generally accepted...Department of European LawKatedra evropského právaPrávnická fakultaFaculty of La
Assessing Tolerability with the Functional Assessment of Cancer Therapy Item GP5: Psychometric Evidence from LIBRETTO-531, a Phase 3 Trial of Selpercatinib in Medullary Thyroid Cancer
No full textBACKGROUND: This psychometric analysis generated evidence to support the use of the Functional Assessment of Cancer Therapy item GP5 (GP5) as a measure of tolerability and confirms the appropriateness of categorizing high side-effect burden using a rating of 3 or 4 (score ranges 0-4) in patients with advanced/metastatic RET-mutant medullary thyroid cancer (MTC).
METHODOLOGY: Blinded, pooled interim data from the safety population (n=290) enrolled in the phase 3 LIBRETTO-531 trial (NCT04211337) were used. Intraclass correlation coefficients (ICC) were calculated for test-retest reliability using data from cycles 1-2 post-baseline. Construct validity was evaluated by examining the correlations of GP5 ratings with (a) symptomatic adverse events (AEs; measured by the PRO-CTCAE), and (b) functioning scores of EORTC QLQ-C30. The ability to detect change over time was examined by Cochrane-Mantel-Haenszel tests for GP5 ratings and PRO-CTCAE. The relationship of high side-effect burden categories with QLQ-C30 functioning scores was examined.
RESULTS: ICCs for the GP5 ratings after cycle 1 ranged between 0.80 and 0.85, indicating good reliability. Correlations between GP5 and PRO-CTCAE items ranged from 0.18 to 0.62 and ranged from -0.37 to -0.50 for QLQ-C30 functioning scores, consistent with study assumptions. Post-baseline GP5 ratings showed significant associations with PRO-CTCAE scores (p
CONCLUSIONS: This analysis generated evidence supportive of the psychometric properties of the GP5 as a fit-for-purpose measure to assess treatment tolerability in patients with advanced/metastatic MTC. The definition of high side-effect burden was associated with the clinical feature of tolerability
Assessing tolerability with the Functional Assessment of Cancer Therapy item GP5: psychometric evidence from LIBRETTO-531, a phase 3 trial of selpercatinib in medullary thyroid cancer
No full textAbstract Background This psychometric analysis generated evidence to support the use of the Functional Assessment of Cancer Therapy item GP5 (GP5) as a measure of tolerability and confirms the appropriateness of categorizing “high side-effect burden” using a rating of 3 or 4 (score ranges 0–4) in patients with advanced/metastatic RET-mutant medullary thyroid cancer (MTC). Methodology Blinded, pooled interim data from the safety population (n=290) enrolled in the phase 3 LIBRETTO-531 trial (NCT04211337) were used. Intraclass correlation coefficients (ICC) were calculated for test-retest reliability using data from cycles 1-2 post-baseline. Construct validity was evaluated by examining the correlations of GP5 ratings with (a) symptomatic adverse events (AEs; measured by the PRO-CTCAE), and (b) functioning scores of EORTC QLQ-C30. The ability to detect change over time was examined by Cochrane-Mantel-Haenszel tests for GP5 ratings and PRO-CTCAE. The relationship of “high side-effect burden” categories with QLQ-C30 functioning scores was examined. Results ICCs for the GP5 ratings after cycle 1 ranged between 0.80 and 0.85, indicating good reliability. Correlations between GP5 and PRO-CTCAE items ranged from 0.18 to 0.62 and ranged from -0.37 to -0.50 for QLQ-C30 functioning scores, consistent with study assumptions. Post-baseline GP5 ratings showed significant associations with PRO-CTCAE scores (p<0.001). Participants with GP5 ratings of 3 or 4 had worse physical function than those with GP5 ratings of 0 to 2 (p<0.0001). Conclusions This analysis generated evidence supportive of the psychometric properties of the GP5 as a fit-for-purpose measure to assess treatment tolerability in patients with advanced/metastatic MTC. The definition of “high side-effect burden” was associated with the clinical feature of tolerability
O vztazích mezi tematickými posloupnostmi a kohezními vazbami ve vybraných moderních povídkách a pohádce
No full textDiplomová práce se zabývá srovnáním dvou povídek Angely Carterové s pohádkou, ze které vycházejí. Cílem práce je určit, do jaké míry autorka ve svých povídkách zachovala jazykovou strukturu pohádky. Práce také interpretuje motivaci a efekt odchylek struktury obou povídek od struktury pohádky. Všechny tři zmíněné texty jsou analyzovány ze tří hledisek: tematických posloupností, předmětů řeči a kohezních řetězců, a kohezních vazeb. Texty jsou nejprve popsány odděleně, poté se práce zaměří na jejich porovnání. Pozornost je věnována především odlišnostem mezi povídkami na jedné straně a pohádkou na straně druhé. Ze srovnání vyplývá, že struktura pohádky byla v povídkách ve velké míře zachována, protože texty sdílí charakteristiky na všech třech úrovních analýzy. Podařilo se nalézt dva vzájemně propojené aspekty, které vedou k rozdílům mezi strukturou povídek a pohádky: věk zamýšlených čtenářů a kontext a prostředí příběhu.This thesis focuses on the comparison of two short stories by Angela Carter with the fairy tale on which they are based. It attempts to discern to what extent the author preserved the structure of the fairy tale, as viewed from a linguistic point of view, in her short stories. The thesis also suggests an interpretation of the motivation and effect of the divergences of the structure of the short stories from that of the fairy tale. The three texts are analysed from three points of view: thematic progressions, discourse subjects and cohesive chains, and cohesive ties. Attention is payed first to the description of the individual texts, and then to the comparison of the three texts. The comparison puts emphasis on the distinction between the shorts stories on one hand and the fairy tale on the other hand. The comparison shows that the structure of the fairy tale is to a large extent retained in the short stories, as they share characteristics on all the three levels of analysis. The short stories were found to differ from the fairy tale in two main respects, connected to each other, which influence the differences in their structure: the age of the intended reader, and the context and setting of the story.Katedra anglického jazyka a literaturyPedagogická fakultaFaculty of Educatio
P1112: PATIENT-REPORTED OUTCOMES (PRO) AMONG PATIENTS WITH MANTLE CELL LYMPHOMA RECEIVING PIRTOBRUTINIB AFTER PRIOR COVALENT BTKI: INTERIM PRO ANALYSIS FROM THE BRUIN PHASE 1/2 STUDY
No full textPatient-reported outcomes among patients with mantle cell lymphoma or chronic lymphocytic leukemia receiving pirtobrutinib in the BRUIN phase 1/2 study: final analysis.
No full textBACKGROUND: This study presents patient-reported outcomes (PROs) from the phase 1/2 BRUIN (NCT03740529) trial of pirtobrutinib monotherapy for the treatment of B-cell malignancies, including chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) and mantle cell lymphoma (MCL).
METHODS: PROs were collected at each cycle using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire and item library (IL) sets for CLL/SLL- and MCL-related symptoms and an Expanded Fatigue measure. Prespecified analyses included descriptive change from baseline, time to worsening (TTW) using Kaplan-Meier method, and longitudinal analyses using a mixed model for repeated measures.
RESULTS: A total of 263 patients with CLL/SLL and 124 with non-blastoid MCL who received pirtobrutinib monotherapy after prior BTKi were included in the final PRO analysis. The proportion of patients with CLL/SLL who improved or remained stable from baseline through Cycle 31 remained above 80% for physical function (PF), CLL/SLL-related symptoms, fatigue, and global health status/quality of life (GHS/QoL). The proportion of patients with MCL who improved or remained stable through Cycle 20 remained above 70% for PF, MCL-related symptoms, fatigue, and GHS/QoL. Median TTW was not reached in either CLL or MCL. Longitudinal analyses for PF, CLL/SLL-related symptoms, fatigue, and GHS/QoL consistently met statistically significant and clinically-meaningful improvement from baseline for CLL. PRO assessments remained stable over time for MCL.
CONCLUSIONS: The final analysis from the BRUIN trial demonstrates stability in PROs throughout the duration of treatment with pirtobrutinib. Most patients with CLL/SLL and MCL reported stable or improved outcomes throughout the study
