4,037 research outputs found
Prediction of long-term pore pressure dissipation behavior by short-term piezocone dissipation test
No full textThe coefficient of consolidation determined from piezocone dissipation test and common interpretation methods makes the predicted dissipation curve match only at 50% degree of dissipation of the measured dissipation curve. It makes it difficult to predict the long-term pore pressure dissipation behavior of in-situ soft deposits. Therefore, based on the authors' previous result [Kim YS, Lee SR, Kim YT. Application of an optimization design technique for determining the coefficient of consolidation by using piezocone test data. Computers and Geotechnics 1997;21(4): 77-93] in which an optimized coefficient of consolidation reflects well the measured dissipation trend over the input degree of dissipation range, a systematic way of predicting a more realistic pore pressure dissipation behavior at high degree of dissipation with the optimized coefficient of consolidation is proposed. It was found that, relatively over the wide range of dissipation, the optimized coefficient of consolidation is more consistent than those determined by other researchers' methods. Applied to some real examples, it is also shown that the dissipation behavior of pore water pressure at a high degree of the dissipation range can be predicted well if the coefficient of consolidation is determined using the optimization technique with the data up to around 50% dissipation. Thus, it is expected that the proposed method saves time and expenses in conducting dissipation tests in the held. (C) 2000 Published by Elsevier Science Ltd. All rights reserved
Generation Ys' employment expectations: UK undergraduates' opinions on enjoyment, opportunity and progression
No full textGeneration Y can be taken to be the group of people born between 1977 and 2000. The aim of this paper is to investigate the initial career entry and long-term career employment expectations of UK undergraduate Generation Ys, in order to inform employability skills development in higher education. The empirical research comprises 26 focus groups with 172 undergraduates of this generation in 2 universities in the UK. The focus group participants are found predominantly to have high expectations of their employment in enjoyment, opportunity and progression. Overall, the respondents appear enthusiastic and optimistic, with a positive work ethic and healthy mindset. Fundamentally, recognising and appreciating undergraduate Generation Ys’ opinions on their employment expectations enables development of their employability skills while they are in university. The paper sets out implications for higher educational stakeholders including students, graduates and employers on the development of employability skills
Simulation with YS domain having two open ends.
No full text<p>(<b>a</b>) initial condition of Y and S: we place the rectangular YS domain in the center, with high concentrations (Y = 1.0 and S = 0.5) inside the rectangle (5 space steps wide ×80 space steps long) and low concentrations (Y = 0.0 and S = 0.0) outside that rectangle. (<b>b, c</b>) two activator peaks emerge simultaneously at the two open ends of the YS domain, marked by the asterisks. (<b>d, e, f, g</b>) these two activator peaks induce more activator peaks to form along the YS domain, marked by double-arrows, in a wave-like manner, until the YS domain is filled up. Parameters: = 0.002, = 0.16, = 0.04, = 0.03, = 0.0001, = 0.02, = 0.26. Space step dx = 0.3, time step dt = 0.4dx<sup>2</sup>.</p
Activator peaks march inward and evolve periodic patterns along the YS domain.
No full text<p>(<b>a</b>) initial condition of Y and S: high concentrations (Y = 1.0 and S = 0.5) inside the rectangle (5 space steps wide ×80 space steps long) and low concentrations (Y = 0.0 and S = 0.0) outside that rectangle. (<b>b, c</b>) a first activator peak emerges at the open end of the rectangularly-shaped YS domain, marked by the asterisk. (<b>d, e, f, g</b>) this first activator peak induces new activator peaks to form along the YS domain, marked by double-arrows, in a wave-like manner, until the YS domain is filled up. Parameters: = 0.002, = 0.16, = 0.04, = 0.03, = 0.0001, = 0.02, = 0.26.</p
Immuno-oncology for B-cell lymphomas
No full textThe goal of cancer immunotherapy is to restore and optimize the immune response against malignant clones through several stages, from recognition of tumor antigens to establishment of long-lived memory cell populations. Boosting the intrinsic anti-tumor immune responses of the patients' own, several types of “active immunotherapies” have been tried in many types of malignancies, inspired by successful experiences of immune checkpoint inhibition even in Hodgkin lymphoma. However, in B-cell non-Hodgkin lymphomas, clinical usefulness of such “active immunotherapies” is relatively unsatisfactory considering the remarkable advances in “passive immunotherapy,” including CD19-targeting chimeric antigen receptor T-cell therapy. Understanding how tumor cells and immune cells interact and contribute to immune evasion processes in the tumor microenvironment (TME) is an important prerequisite for the successful restoration of anti-tumor immune responses. In this review, a recent understanding of the biology of the immune tumor microenvironment surrounding B-cell non-Hodgkin lymphomas will be introduced. In addition, novel therapeutic approaches targeting the immune microenvironment other than immune checkpoint blockade are discussed
Congenital Hypothyroidism: Long-Term Growth and Intellectual Outcomes With a Lower Initial Levothyroxine Dose
No full textOBJECTIVES: This study aims to review the long-term outcome of congenital hypothyroidism (CH) and whether patient- or treatment-related factors impact the outcomes, especially focusing on the initial Levothyroxine dose. METHODS: This is a retrospective, cross-sectional study of the children diagnosed with CH who received Levothyroxine at Ajou University Hospital between 2003 and 2024. Comparative analysis was performed between the low (<10 mcg/kg) and high (>/=10 mcg/kg) initial dose groups. Repeated-measures analysis of covariance was employed to evaluate longitudinal changes in growth outcomes, and multivariate linear regression was utilised to evaluate the effects of clinical factors on the intelligence quotient (IQ). RESULTS: Among the study population, 84 of 144 children were prescribed an initial low dose of Levothyroxine. Most children in both initial dose groups showed appropriate growth within the normal range in the biennial growth evaluation from ages four to eight and in the Wechsler IQ exam. The initial dose seemed to not significantly affect the growth outcomes over time, as no significant differences between the low- and high-dose groups were observed (p values: 0.545, 0.609, 0.532, and 0.501 for bone age-chronological age, height z-score, weight z-score, and BMI z-score, respectively). The effect of the initial dose group on the full-scale IQ was also not statistically significant (p = 0.362). CONCLUSION: We demonstrated the favourable long-term outcomes in linear growth and neurodevelopment among children with CH, even in lower initial Levothyroxine doses
Cyclic Fatigue-Crack Propagation Behavior in Silicon Carbide: Long- and Small-Crack Behavior
No full textCyclic fatigue properties of high-toughness SiC with additives of Al2O3 and Y2O3 were examined, with a focus on differences between long- (>3 mm) and small-crack (<200 <mu>m) behavior. Small cracks were initiated with Vickers indents placed on the tensile surfaces of beams, and crack extension was monitored optically under cyclic load. For small cracks, high growth rates which exhibited a negative dependence on the far-field driving force were observed. Such behavior was explained by both indent-induced residual stresses and the relative size of cracks compared with bridging zone lengths
Efficient coherent neighbour cell search for synchronous 3GPP LTE system
No full textFor a coherent neighbour cell search, the 3GPP long term evolution system detects a cell-specific secondary synchronisation channel by using the channel response estimated from the primary synchronisation channel (P-SCH). Owing to the limited number of P-SCH sequences, however, the channel response estimated from P-SCH does not exactly match the channel response of the target neighbour cell. To mitigate the effect of such channel mismatch problems, a simple technique is proposed which improves coherent neighbour cell search performance significantly.X111117sciescopu
New family of monoglucosylglyceride diacyl glycerol lipids containing very long chain bifunctional acyl chains in Sarcina ventriculi
No full textRecent research on the fatty acyl chains in the membrane lipids in Sarcina ventriculi has shown that unusually long chain bifunctional fatty acyl components are the major components of the total lipid. However, these studies did not yield any information on the complete structures of the lipid species containing these fatty acids. In this study, the structures of a new family of glucolipids containing bifunctional acyl chains are described. These structures were determined using NMR (Nuclear Magnetic Resonance) spectroscopy, GC (Gas Chromatography)/MS (Mass Spectrometry), FTIR (Fourier Transform Infrared) spectroscopy, and FAB (Fast Atom Bombardment) mass spectrometric studies. One of the major bifunctional acyl components of the alpha-glucolipids was an omega-formylmethyl ester indicating the presence of plasmalogen. The general structure of the lipid components was one in which the two head groups were separated by a membrane-spanning acyl species. One head group component is a glycerol moiety of each head group, and the other is a glyceryl glucoside. Two regular chain fatty acids, one on the glycerol moiety of each head group, are also present and meet in the middle of the membrane, roughly equidistant from each head group.X111sciescopu
Long-Term Trend of Green and Golden Tides in the Eastern Yellow Sea
No full textSince 2008, floating green tides (Ulva sp.) have been occurring continuously in the Yellow Sea (YS), and after 2013 floating golden tides (Sargassum sp.) have also occurred. The distribution, areal coverage, and migration of floating green tides have been actively studied, but most research has focused only on the western YS. Little is known about the floating golden tides in the eastern YS. The purpose of this study was to determine the long-term distribution of floating green and golden tides in the eastern YS using Geostationary Ocean Color Imager (GOCI), Moderate Resolution Imaging Spectroradiometer (MODIS), and Landsat satellite images from 2008 to 2017. In addition, the migration of floating macroalgae with Global Hybrid Coordinate Ocean Model (HYCOM) surface current data were compared. Green tides were observed in 2008, 2009, 2011, 2015, and 2016 in the eastern YS. From a satellite image backtracking analysis, it was confirmed that the green tides observed in the eastern YS were supplied from the western YS. When the maximum areal coverage of green tide was compared between the eastern and western YS, the coverage in the eastern YS was found to be about 4 % of that of the western YS. However, in 2011, the largest amount of floating macroalgae was found in the eastern YS and it accounted for about 45 % of the amount in the western part of the YS. In the eastern YS, floating golden tides were found in 2013, 2015, 2016, and 2017, with the largest amount of floating macroalgae occurring in 2017. Although there were no long-term golden tide data for the western YS, such that it was not compared to the areal coverage of the eastern YS, it was confirmed that the amount of golden tide supplied to the eastern YS gradually increased. A comparison between the migration of floating macroalgae and HYCOM surface current data suggested that the migration and flow directions were not identical, and were considerably affected by surface ocean currents during their passage into the eastern YS. From this study, the long-term distribution and changes in areal coverage of green and golden tides in the eastern YS were obtained for the first time. This information will be useful for understanding the long-term patterns of green and golden tides, and provides basic data for predicting the occurrence and migration of floating macroalgae.11Nsciescopu
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