1,354,983 research outputs found
Show your work : A Conversation with Frank LoMonte
No full textIn this installment, JNP sits down with Frank LoMonte to talk about the importance of student media, the value of journalism education, and the need for transparency and the free flow of information. Frank LoMonte is the Director of the Brechner Center for Freedom of Information at the University of Florida. Prior to that, he was the Executive Director of the Student Press Law Center in Washington, D.C.
Brechner Center for Freedom of Information: http://brechner.org/Student Press Law Center: http://www.splc.org
Censorship Makes the School Look Bad: Why Courts and Educators Must Embrace the Passionate Conversation
No full textThis Article analyzes the Supreme Court’s decision in Hazelwood School District v. Kuhlmeier. The Court held that students have no freedom to choose the content of school-sponsored newspapers or other curricular vehicles, so long as the justification for censorship is “reasonably related to legitimate pedagogical concerns.” LoMonte argues the Court erred in elevating the government’s reputation to a concern of constitutional value. LoMonte urges the Supreme Court to re-think its decision as it has done with respect to persons in other categories. Young people use their talents to organize reform movements and have political opinions worth hearing, particularly about the education they are receiving
Inhibition of adenylosuccinate lyase by 2’,3’-acyclic substrate analogs.
No full textAdenylosuccinate lyase catalyzes the trans-elimination of fumarate from adenylosuccinate to yield AMP. The catalysis is not affected by opening the ribose ring of the substrate. The addition of aliphatic chains on the ring does not markedly affect the binding of the substrate analog, though preventing its cleavage
Development of a Desktop Application to Enable Doctors to Remotely Monitor Patients’ Hematological Parameters
No full textThe constant advancement of technology has revolutionized the healthcare industry, introducing new opportunities for improved medical services. Desktop applications have emerged as a versatile platform for enhancing healthcare delivery, providing efficient access to medical information and services. In this paper, we explore the development of a desktop application tailored specifically as a side application to a non-invasive anemia detection system, to allow patients and physicians to easily interact. By leveraging our expertise in software engineering principles and collaborating closely with medical experts, we present a comprehensive framework that incorporates advanced features, security protocols, and intuitive user interfaces, ensuring a reliable and secure desktop application that enables doctors to remotely monitor patients’ hematological parameters extracted from the mobile application on the patients’ smartphone
Structural performance of a large-span bi-directional partially precast waffle slab system under fire exposure
No full textThis paper describes the evaluation of the structural performance under fire exposure of a partially precast waffle slab system employed in the 1970s for the construction of residences in high-mountain skying stations in the Italian Alpine arch. Full information is available about this structural arrangement, including geometry and reinforcement shop drawings, and material properties, adjuvated by on-site non-destructive detection tests. The bi-directional waffle slab system at study was not designed according to any specific rule or calculation concerning fire resistance. The performance of the slab system under fire exposure is investigated through numerical analysis employing non-linear equivalent beam elements under the standard ISO 834 temperature-time exposure, where sectional non-linear temperature distribution and moment-curvature diagrams are evaluated separately and attributed to the numerical model. The modelling is aimed at evaluating the structural performance of the waffle slab under fire exposure with an advanced method taking into account of indirect actions caused by the temperature rise in this highly-statically-undetermined structural arrangement, cheking the actual safety as well as stress and deformation profiles of the slab members under different time exposures. The simulation also aims at assessing the benefits brought in by structural redundancy and stress/force redistribution capacity, this being of primary importance for structures not designed to withstand the recent provisions in case of fire
La valutazione della capacità sismica di un edificio in c.a. progettato per i soli carichi verticali finalizzata alla messa a punto di una metodologia semplificata
No full textUsing Automatic Low-Voltage Regulators to Increase Distribution Networks' Hosting Capacity: A Real case Study in Milan, Italy
No full textThe energy transition is leading to growing electrification of consumption and production from non-programmable renewable sources within distribution networks. In this scenario, new challenges emerge in the operation of distribution networks, which distribution system operators must efficiently manage. The paper investigates a real case study in Milan's distribution network where frequent overvoltage and under-voltage problems have led to the deployment of an automatic low-voltage regulator to guarantee a reliable service of a long rural low-voltage feeder with photovoltaic and storage systems connected to it. Firstly, the paper presents current voltage issues in distribution networks, the working principle of the installed low-voltage regulator and a brief description of the feeder under study. Secondly, after the description of the optimal sizing and location through the feeder, the field data collected by the low-voltage regulator over a couple of months is punctually and statistically analyzed to demonstrate the valuable impact on voltage stability. In the end, the paper highlights the benefits gained by Unareti, Milan's distribution system operator, comparing the presented innovative voltage control solution with the traditional approach of network reinforcement from both technical and economic points of view
03 02 a RE Lomonte-03-05-11.qxp
No full textPLA 2 s constitute a large superfamily of enzymes which are widely distributed in living organisms. On the basis of their structural and biochemical properties, these enzymes have been classified within at least 15 groups Abstract Phospholipases A 2 (PLA 2 s) are abundant components in snake venoms, which play important toxic roles. This review focuses on group II PLA 2 s endowed with myotoxic effects, present in Viperidae venoms. These PLA 2 s are subdivided into catalytically-active (Asp49) PLA 2 s, and catalytically-inactive PLA 2 homologues, the latter most frequently presenting the Lys49 substitution. Both protein subgroups induce skeletal muscle necrosis, although by different mechanisms. Current evidence indicates that phospholipid hydrolysis plays a central role in the necrotizing action of Asp49 myotoxins, whereas PLA 2 homologues rely on the direct membrane-destabilizing actions of their cationic C-terminal region to achieve such effect, in the absence of catalysis. Both mechanisms converge in sarcolemmal permeabilization, triggering a series of intracellular events that lead to necrosis. Most viperid PLA 2 myotoxins act only locally, but those forming heterodimeric complexes such as crotoxin spread to distant muscles and induce rhabdomyolysis. This divergence between local and systemic myotoxicity might be related to differences in binding specificity to cell targets. Nevertheless, the identity of molecular targets recognized by viperid PLA 2 myotoxins remains elusive. Identification of their membrane target(s), and a deeper understanding of the catalytic-dependent and -independent mechanisms that result in membrane destabilization, are two crucial, but still unclarified aspects of their myotoxic action
Cellular pathology induced by snake venom phospholipase A(2) myotoxins and neurotoxins: common aspects of their mechanisms of action
No full textA large variety of snake toxins evolved from PLA(2) digestive enzymes through a process of 'accelerated evolution'. These toxins have different tissue targets, membrane receptors and mechanisms of alteration of the cell plasma membrane. Two of the most commonly induced effects by venom PLA(2)s are neurotoxicity and myotoxicity. Here, we will discuss how these snake toxins achieve a similar cellular lesion, which is evolutionarily highly conserved, despite the differences listed above. They cause an initial plasma membrane perturbation which promotes a large increase of the cytosolic Ca(2+) concentration leading to cell degeneration, following modes that we discuss in detail for muscle cells and for the neuromuscular junction. The different systemic pathophysiological consequences caused by these toxins are not due to different mechanisms of cell toxicity, but to the intrinsic anatomical and physiological properties of the targeted tissues and cells
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