203,996 research outputs found

    Gymnothorax melanosomatus Loh, Shao & Chen 2011

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    * Gymnothorax melanosomatus Loh, Shao & Chen, 2011 ΑAAΟR Gymnothorax melanosomatus Loh, Shao & Chen, 2011: 44, figs. 1–2 (type locality: offshore from Changbin, Taitung, Taiwan, 50–100 m). Smith, 2012: 19; Loh et al., in press:table 1; Loh et al., 2015: 30. Remarks. A relatively deep-living species that is commonly collected by hook and line off southeastern Taiwan.Published as part of Ho, Hsuan-Ching, Smith, David G., Mccosker, John E., Hibino, Yusuke, Loh, Kar-Hoe, Tighe, Kenneth A. & Shao, Kwang-Tsao, 2015, Annotated checklist of eels (orders Anguilliformes and Saccopharyngiformes) from Taiwan, pp. 140-189 in Zootaxa 4060 (1) on page 157, DOI: 10.11646/zootaxa.4060.1.16, http://zenodo.org/record/24365

    Pylorobranchus hoi McCosker, Loh & Lin 2012

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    * Pylorobranchus hoi McCosker, Loh & Lin, 2012 ¼R÷№ª Pylorobranchus hoi McCosker, Loh & Lin in McCosker et al., 2012: 1192, figs. 1–4 (type locality: Changbin, 23 ° 18 'N, 121 ° 29 'E, Taitung County, Taiwan, 300 m). McCosker, 2014: 337. Remarks. A deepwater species known only from the type series collected by hook and line off southeastern Taiwan.Published as part of Ho, Hsuan-Ching, Smith, David G., Mccosker, John E., Hibino, Yusuke, Loh, Kar-Hoe, Tighe, Kenneth A. & Shao, Kwang-Tsao, 2015, Annotated checklist of eels (orders Anguilliformes and Saccopharyngiformes) from Taiwan, pp. 140-189 in Zootaxa 4060 (1) on page 175, DOI: 10.11646/zootaxa.4060.1.16, http://zenodo.org/record/24365

    Gymnothorax taiwanensis Chen, Loh & Shao 2008

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    * Gymnothorax taiwanensis Chen, Loh & Shao, 2008 e*AΟR Gymnothorax taiwanensis Chen, Loh & Shao, 2008: 132, figs. 1–2 (type locality: offshore from Shihtiping, 23 ° 29 'N, 121 ° 30 'E, Hualien, eastern Taiwan, 10 m). Ho & Shao, 2011: 22, table 1; Smith, 2012: 28; Loh et al., in press:table 1. Remarks. A species commonly collected by hook and line in the coral reef regions of southeastern Taiwan.Published as part of Ho, Hsuan-Ching, Smith, David G., Mccosker, John E., Hibino, Yusuke, Loh, Kar-Hoe, Tighe, Kenneth A. & Shao, Kwang-Tsao, 2015, Annotated checklist of eels (orders Anguilliformes and Saccopharyngiformes) from Taiwan, pp. 140-189 in Zootaxa 4060 (1) on page 161, DOI: 10.11646/zootaxa.4060.1.16, http://zenodo.org/record/24365

    [Book Reviews] Re-engineering at Work, by M. Loh

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    Book review of "Re-engineering at Work" by M. Loh, published by Gower Publishing Ltd, Aldershot in 1995 (ISBN 0 566 07642 X

    Linewidth and phase noise characteristics of DFB fibre lasers

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    The anomalous linewidth behavior in a DFB fiber laser is investigated. It is shown that not only does the linewidth deviate drastically from the Schawlow-Townes linewidth formula by increasing with pump and laser power, but it also varies significantly with the pumping configuration used. These results have potentially important implications for the design and operation of such fiber lasers

    Wavelength conversion in a short length of a solid lead-silicate fibre

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    We experimentally demonstrate a four-wave-mixing-based wavelength conversion scheme at 1.55 µm using a 1.1-m length of highly nonlinear, dispersion tailored W-type lead–silicate optical fibe

    Influence of MSI and 18q LOH markers on capecitabine adjuvant monotherapy in colon cancer patients

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    Nadica Matevska-Geshkovska,1 Marija Staninova-Stojovska,1 Aleksandra Kapedanovska-Nestorovska,1 Natalija Petrushevska-Angelovska,2 Milco Panovski,3 Biljana Grozdanovska,2 Nenad Mitreski,2 Aleksandar Dimovski1 1Center for Biomolecular Pharmaceutical Analyses, Faculty of Pharmacy, Ss. Cyril and Methodius University in Skopje, Skopje, Macedonia; 2University Clinic for Oncology and Radiotherapy, Ss. Cyril and Methodius University in Skopje, Skopje, Macedonia; 3University Clinic for Abdominal Surgery, Ss. Cyril and Methodius University in Skopje, Skopje, Macedonia Purpose: The aim of this study was to evaluate whether pretreatment analysis of selected molecular markers can be used for the prediction of disease-free survival (DFS)/overall survival (OS) of capecitabine adjuvant monotherapy in colon cancer patients.Patients and methods: A total of 126 patients enrolled in a capecitabine Phase IV clinical trial were analyzed for microsatellite instability (MSI), 18q loss of heterozygosity (LOH), thymidylate synthase (TYMS) 5′ variable number of tandem repeat (VNTR), and methylene tetrahydrofolate reductase (MTHFR) C677T variants. The significance in predicting 5-year DFS/OS was assessed by Kaplan–Meier and Cox regression analyses.Results: The MSI-high (MSI-H) genotype was significantly associated with DFS (HR 0.205, 95% CI 0.05–0.88, P=0.033) and OS (HR 0.208, 95% CI 0.05–0.89, P=0.035) compared to the microsatellite stable genotype. In models stratified according to clinicopathologic characteristics, the MSI-H genotype remained a positive predictive factor for DFS/OS only in patients with stage III (P=0.023) and patients with tumors localized proximally to the splenic flexure (P=0.004). Distal colon cancers with 18q LOH have a greater survival rate when treated with capecitabine than patients with stable tumors (81.3% vs 50.0%, HR for relapse 0.348, 95% CI 0.13–0.97, P=0.043). TYMS 5′VNTR and MTHFR C677T variants were not associated with DFS or OS.Conclusion: MSI and 18q LOH markers have the potential to be utilized in the selection of colon cancer patients eligible for capecitabine adjuvant monotherapy. Keywords: gastrointestinal cancer, microsatellite instability, 18q allelic imbalance, prognostic marker&nbsp

    Johannes Loh, Homiletik und Psychologie, Frankfurt a. M., Peter Lang, 2007

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    Parmentier Elisabeth. Johannes Loh, Homiletik und Psychologie, Frankfurt a. M., Peter Lang, 2007. In: Revue d'histoire et de philosophie religieuses, 90e année n°2, Avril-Juin 2010. pp. 286-287

    LOH profile and malignant tumor type correlate to <i>brca2</i> genotype.

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    <p>(<b>A</b>) Relative prevalence of each LOH profile for malignant tumors from <i>brca2+/+;tp53+/m</i>, <i>brca2+/m;tp53+/m</i>, and <i>brca2 m/m;tp53+/m</i> zebrafish. (<b>B</b>) LOH profiles of MPNST (left) and undifferentiated sarcomas (right). <i>brca2</i> loss of function refers to either homozygous <i>brca2</i> mutation or loss of the <i>brca2</i> wildtype allele. (<b>C</b>) Model depicting the roles for haploinsufficiency, LOH, and homozygous mutation in <i>brca2</i> and <i>tp53</i> during malignant transformation. Solid arrows indicate more common pathways of carcinogenesis; dashed arrows indicate less common pathways of carcinogenesis. MPNST, malignant peripheral nerve sheath tumor, LOH, loss of heterozygosity.</p

    LOH at the MCPH1 locus.

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    <p>(A) Representative phosphor images showing LOH for the markers D8S1819, D8S277 and D8S1798 flanking the MCPH1 locus. B & T denote constitutive blood/normal oral tissue and tumor DNA respectively. Arrows indicate the loss of alleles in tumor DNA. (B) Diagrammatic representation of LOH data from 81 matched blood/normal oral tissue and tumor DNA samples using three microsatellite markers. Tumor samples are arranged according to their T classification (T1 to T4) or ED (epithelial dysplasia). Abbreviations: NI, non-informative; IN, informative; MSI, microsatellite instability; and, L, LOH.</p
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