1,721,182 research outputs found

    Glutathione interacts with neuronal membranes in the frog central nervous system.

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    Studying the effects of GSH on the activity of spinal cord, it was found that: 1) GSH suppresses potentials reversibly; 2) cords pretreated with GSH and successively exposed to mBBr or NEM, mantain their normal spontaneous potentials.These results suggest that GSH interacts with the membrane sulfhydryl groups possibly involved in the electrical activity

    Gut-brain axis: A new revolution to understand the pathogenesis of autism and other severe neurological diseases

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    The gut-brain axis (GBA) is a complex communication network interfacing the gut and the brain of a single individual. The central (CNS) and enteric (ENS) nervous systems are, of course, communicating; however, other pathways are involved in GBA, among which are immune activation, intestinal barrier function, and enteroendocrine signaling. All these communication lines are bidirectional and involve neuro-immuno-endocrine mediators. The reason for the development of such a complex network is to maintain gastrointestinal homeostasis keeping in mind its links with cognitive and affective functions. Recently, the role of enteric flora, or microbiota, has been recognized as a part of the gut-brain axis. The gut microbiota can modulate brain function, forming a crucial link in the bidirectional interactions between the intestine and the nervous system
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