106,421 research outputs found
Lu AA21004, a multimodal psychotropic agent, in the prevention of relapse in adult patients with generalized anxiety disorder
No full textThe purpose of this study was to investigate the long-term maintenance of the efficacy of Lu AA21004 5 or 10 mg/day in the prevention of relapse in patients with generalized anxiety disorder (GAD). Patients (n = 687) with a primary diagnosis of GAD (DSM-IV criteria) and a baseline Hamilton Anxiety (HAM-A) total score of at least 20 underwent a 20-week, open-label Lu AA21004 treatment. In all, 459 patients responded and were randomized to 24-56 weeks of a double-blind treatment with Lu AA21004 (n = 229) or placebo (n = 230). The predefined primary efficacy endpoint was time to relapse (HAM-A total score ? 15) using a Cox model; the key secondary efficacy endpoint under multiplicity control was time to relapse for patients responding to treatment for at least 12 weeks. The primary analysis showed a statistically significant effect of Lu AA21004 relative to the placebo on the time to relapse of GAD, with a hazard ratio of 2.71 (P < 0.001). There was a statistically significant effect of Lu AA21004 in the stable responders (hazard ratio = 3.06, P < 0.001). Lu AA21004 was well tolerated, with withdrawal rates due to adverse events of 9% (open-label) and 3% (placebo) and 4% (Lu AA21004) in the double-blind period. In this study, Lu AA21004 5 or 10 mg/day was efficacious in preventing relapse and was well tolerated in the maintenance treatment of GAD.<br/
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LOFT LOCE fuel module structural response
No full textThe purpose of the LOFT fuel structural response evaluation program is to assess the accuracy of the structural response prediction codes and confirm that LOFT fuel bundle structural integrity will be maintained during the LOFT tests. A WHAM/SHOCK/SAP computer code combination has been developed to predict the LOFT fuel module structural response. LOFT test data have been evaluated, and additional computer code (RELAP/SCORE/MOXY) combinations are being developed for predicting guide tube temperatures during the future LOFT tests
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LOFT reactor advanced instrumented center fuel bundle
No full textThe program for designing and fabricating replacement fuel modules for LOFT provides a method for incorporating improvements in contemporary LPWR fuel design and in-reactor measurement techniques. Special development projects for measurement devices support the LOFT replacement fuel program
Vertical Residential Condominium: loft concept
No full textProposal for the preparation of a preliminary design for a vertical multi-family residential condominium on Rua das Ararajubas, in the São Marcos neighborhood, using the loft concept. The main characteristic of this condominium will be the personalization of spaces, demonstrated by the double-height ceiling, the use of a mezzanine and the almost total elimination of internal walls. Emphasis is placed on the creation of the loft concept by the French architect Le Courbusier, the promotion of the loft in European countries and its heyday in the United States; the introduction into the Brazilian real estate market and the consolidation of this concept in some Brazilian capitals; the acceptance of the real estate market in São Luís, the behavior of real estate agencies regarding the launch of new concepts and the profile of buyers for this development, their desires and motivations.Proposta para elaboração do anteprojeto de um
condomínio residencial vertical e multifamiliar, à
Rua das Ararajubas, no bairro São Marcos,
utilizando o conceito loft. Este condomínio terá
como característica principal a personalização dos
espaços demonstrada através do pé-direito duplo, a
utilização de mezanino e a eliminação, quase que
total, das paredes internas.
Enfatizam-se a criação do conceito loft pelo
arquiteto francês Le Courbusier, a divulgação do loft
nos países europeus e o seu apogeu nos Estados
Unidos; a introdução no mercado imobiliário
brasileiro e a consolidação deste conceito em
algumas capitais brasileiras; a aceitação do mercado
imobiliário de São Luís, o comportamento das
Imobiliárias quanto ao lançamento de novos
conceitos e o perfil dos compradores para este
empreendimento, seus anseios e motivações
Effectiveness of Vortioxetine on Emotional Blunting in Patients with Major Depressive Disorder with inadequate response to SSRI/SNRI treatment
No full textIntroduction: Inadequate treatment response and emotional blunting are common challenges with selective serotonin reuptake inhibitors/serotonin-noradrenaline reuptake inhibitors (SSRIs/SNRIs) for major depressive disorder (MDD). We investigated the effectiveness of vortioxetine on emotional blunting in patients with partial response to treatment with SSRIs/SNRIs. Methods: Patients with MDD who experienced a partial response to SSRI/SNRI monotherapy at adequate dose for ≥6 weeks were switched to 8 weeks of vortioxetine treatment 10-20 mg/day (Study NCT03835715). Key inclusion criteria were Montgomery-Åsberg Depression Rating Scale (MADRS) total score >21 and <29, current major depressive episode <12 months, Oxford Depression Questionnaire (ODQ) total score ≥50, and confirmation of emotional blunting by standardized screening question. Emotional blunting was assessed by ODQ and depressive symptoms by MADRS. Other outcomes assessed included motivation and energy (Motivation and Energy Inventory [MEI]), cognitive performance (Digit Symbol Substitution Test [DSST]), and overall functioning (Sheehan Disability Scale [SDS]). Results: At week 8, patients (N=143) had improved by -29.8 points (p<0.0001) in ODQ total score; 50% reported no emotional blunting in response to standardized screening question. Significant improvements were observed on the DSST, MEI, and SDS at all time points assessed, and 47% of patients were in remission (MADRS total score ≤10) at week 8. The most common treatment-emergent adverse events included nausea, headache, dizziness, vomiting, and diarrhea. Limitations: No prospective phase before medication switch. Conclusion: Vortioxetine 10-20 mg effectively improved emotional blunting, overall functioning, motivation and energy, cognitive performance, and depressive symptoms in patients with MDD with partial response to SSRI/SNRI therapy and emotional blunting
LOFT suppression tank spray system piping: heat exchanger BS-H-31 piping modifications
No full textA stress analysis of the piping modification, resulting from relocation of heat exchanger BS-H-31 of the LOFT Blowdown Suppressing Tank Spray System, was performed. The piping, fittings, and supports were found to comply with the criteria of Section III of the ASME Boiler and Pressure Vessel Code, 1974
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LOFT blowdown experiment safety analysis methodology
No full textAn unprecedented blowdown experiment safety analysis (ESA) has been performed for the first two scheduled nuclear experiments in the Loss-of-Fluid Test (LOFT) facility. The ESA methodology is a unique approach needed to estimate conservatively the maximum consequences that will occur during an experiment. Through use of this information an acceptable risk in terms of adequate protection of the facility, personnel, and general public can be balanced with the requirements of the experiment program objectives. As an example, one of the LOFT program objectives is to evaluate the performance and effectiveness of emergency core cooling systems (ECCS) while relying on the same ECCSs (and backup ECCSs) to effectively perform as plant protection systems (PPS). The purpose of this paper is to present the LOFT blowdown ESA methodology
Loft Entry at Buskala Ranch, Dumont SD, Lawrence County
No full text35 mm slide, a stack of logs and decaying vegation next to a log structureDrawer info: Finnish, Danish, Swedish; Buskala Ranch LA COKodachrome Slide Log "Bridge" Loft Entry Stable H. Buskala Ranch LA CO 11 May 85O
LOFT CIS analysis penetration S-11B 12'' H and V duct
No full textThe 12 in. H and V Duct and related piping outside the LOFT containment and connected to containment penetration S-11B was analyzed to ASME Code, Subsection NC (Class 2) criteria. This duct is part of the Containment Isolation System. The model considered the duct from the containment O.D. outward through the second isolation valve. Results of this analysis show that this section of the line will meet Class 2 requirements without modification
LOFT CIS analysis: 24'' H and V Duct outside penetration S-12A
No full textThe 24'' H and V Duct and related piping outside the LOFT containment and connected to containment penetration S-12A were analyzed to ASME Section III, Subsection NC (Class 2) criteria. The duct is part of the Containment Isolation System. The model considered the duct from the containment O.D. outward through the second isolation valve. Results of this analysis show that this section of the line will meet Class 2 requirements without modification
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