210 research outputs found
Cytosim codebase extensions for a 2D T cell model
No full textCode is used in "Kinesin-4 KIF21B limits microtubule growth to allow rapid centrosome polarization in T cells", by Peter Jan Hooikaas, Hugo G.J. Damstra, Oane J. Gros, Wilhelmina E. van Riel, Maud Martin, Yesper T.H. Smits, Jorg van Loosdregt, Lukas C. Kapitein, Florian Berger, Anna Akhmanova. The code is an extended form of Cytosim, made by François Nedelec (https://gitlab.com/f.nedelec/cytosim). Only the minor extensions outside of the base code, listed in the README.txt file, can be attributed to author O.J.Gros, other authors are taken from the registered contributors on the cytosim gitlab, as having worked on the code base that was extended
Archetypical Patterns in Agent-Based Models
No full textComplex systems produce recognizable self-organized patterns across time. This conceptual paper consists of a systematic reflection on what kinds of archetypical patterns systems can show, and in what kinds of cases these patterns could occur. Agent-based models are used to exemplify each pattern. We present a classification of the breadth of typical patterns that agent-based models can show when one runs them. The patterns fall into three categories: resource use, contagion, and output patterns. These are pattern archetypes; most real-world systems, and also most models, could and will show combinations of the patterns. In real systems, the patterns will occur as phases and building blocks of developments. These are patterns frequently occurring in real-world systems. The classification is the first of its kind. It provides a way of thinking and a language to non-mathematicians. This classification should be beneficial to those researchers who are familiar with a real-world pattern in their discipline of interest, and try to get a grasp of pattern causation. It can also serve in education, for giving students from a variety of disciplines an idea of the possibilities of agent-based models
De noordsche weereld : vertoond in twee nieuwe, aenmercklijcke, derwaerts gedaene reysen : d'eene, van de heer Martiniere door Norweegen, Lapland, Boranday, Siberien, Samojessie, Ys-land, Groenland en Nova-Zembla ... : dandre, van de Hamburger Frederick Martens, verright nae Spitsbergen of Groenland, in't jaer 1671 ... /
No full textIncludes index.Signatures: *⁴ 2*² A-2X⁴.Added etched t.p. Etched and engraved plates by Cornelis Decker and Jacobus Harrewijn. Woodcut in-text map of Novai︠a︡ Zemli︠a︡.De La Martinière's Voyage des pais septentrionaux first published Paris, 1671. Martens' Spitzbergische oder Groenlandische Reise-Beschreibung first published Hamburg, 1675.Mode of access: Internet.Bookplates of G.J. Honig, of Zaandyk. Inscription by Honig giving auction record: Muller, May 1911, f. 5. Another inscription with auction record: Koch, 1974, fl. 2300. John Landwehr's printed label.Binding: mottled calfskin. Double fillets in gilt along margins of boards, fleurons at corners. Spine tooled in gilt, author & title on red label
Modulation of nitrosative stress by S-nitrosoglutathione reductase is critical for thermotolerance and plant growth in arabidopsis
No full textNitric oxide (NO) is a key signaling molecule in plants. This analysis of Arabidopsis thaliana HOT5 (sensitive to hot temperatures), which is required for thermotolerance, uncovers a role of NO in thermotolerance and plant development. HOT5 encodes S-nitrosoglutathione reductase (GSNOR), which metabolizes the NO adduct S-nitrosoglutathione. Two hot5 missense alleles and two T-DNA insertion, protein null alleles were characterized. The missense alleles cannot acclimate to heat as dark-grown seedlings but grow normally and can heat-acclimate in the light. The null alleles cannot heat-acclimate as light-grown plants and have other phenotypes, including failure to grow on nutrient plates, increased reproductive shoots, and reduced fertility. The fertility defect of hot5 is due to both reduced stamen elongation and male and female fertilization defects. The hot5 null alleles show increased nitrate and nitroso species levels, and the heat sensitivity of both missense and null alleles is associated with increased NO species. Heat sensitivity is enhanced in wild-type and mutant plants by NO donors, and the heat sensitivity of hot5 mutants can be rescued by an NO scavenger. An NO-overproducing mutant is also defective in thermotolerance. Together, our results expand the importance of GSNOR-regulated NO homeostasis to abiotic stress and plant development
Is exercise training safe and effective for ALL heart failure patients: A retrospective service evaluation of a hospital based cardiac rehabilitation programme
No full textThe main purpose of this study was to investigate whether exercise training is safe and effective for all classifications of heart failure, female and elderly (70 years and above) heart failure patients and also those heart failure patients with significant co-morbidity. Much of the research into exercise training and heart failure has been carried out on middle aged men in NYHA II-III classification of heart failure who have no other significant co-existing conditions. This is not reflective of the population of heart failure patients in general. The cardiac rehabilitation records (n=1000) of heart failure patients who had attended an exercise programme at a hospital based NHS service over a period of ten years were retrospectively evaluated to investigate the safety and efficacy of exercise training. Analysis of baseline statistics and repeated outcome measures were used to investigate the significance of the service and to ascertain where similarities and differences lay with the research. 74% were male, the age range was 17-90 years and 52% of patients had one or more significant co-morbidity. The acute event incidence was recorded at four per 1000 patients. NYHA I patients, female, elderly heart failure patients and those with significant co-morbidity showed significant improvements in functional capacity and quality of life measures with exercise training (p< 0.05). However no conclusion on the effectiveness of exercise could be drawn for NYHA IV heart failure patients due to insufficient recorded data and reduced adherence to exercise sessions for this group. A hospital based exercise programme, therefore may not be the most appropriate setting for the NYHA IV patient. This study supports previous research of the benefit of exercise training in heart failure but broadens it further to show that exercise is safe for all heart failure patients and is also effective for all heart failure patients with the exception of NYHA IV patients where further investigation is needed
Analysis of the resource concentration on size and research performance: The case of Italian National Research Council over the period 2000-2004
No full textNowadays the Government of industrialised countries, in presence of reduced public funds, has to manage the public research laboratories to increase the efficiency and research performance, necessary to the competitiveness of firms and of economic systems. The purpose of this paper is to investigate the relationships between size and performance of public research organisations within of the Italian national system of innovation, for the period 2000-2004, which is characterised by two different research policies. The comparative analysis shows that the results can supply useful information to policy makers on the behaviour of these structures. The new research policy based on merger among the research institutes generates higher research performance and scale economies. However some elements suggest to be cautious about this relationship and to further investigate.Research Laboratories, R&D Performance, Size, Public Research, Research Structure, Research Policy
The 'true use of reading' : Sarah Fielding and mid eighteenth-century literary strategies.
No full textPhDThe aim of this thesis is to explore, by examining her life and
works, how Sarah Fielding (1710-68) established her identity as an author.
The definition of her role involves her notions of the functions of
writing and reading.
Sarah Fielding attempts to invite readers to form a sense of ties
by tacit understanding of her messages. As she believes that a work
of literature is produced through collaboration between the writer and
the reader, it is an important task in her view to show her attentiveness
toward reading practice. In her consideration of reading, she has two
distinct, even opposite views of her audience: on the one hand a familiar
and limited circle of readers with shared moral and cultural values and
on the other potential readers among the unknown mass of people. The
dual targets direct her to devise various strategies. She tries to
appeal to those who can endorse and appreciate her moral values as well
as her learning. Her writings and letters testify that she is sensitive
to the demands of the literary market, trying to lead the taste of readers
by inventing new forms.
The thesis opens with an overview of Sarah Fielding's career,
followed by a consideration of her critical attention to the roles of
reading. I go on to examine the narrative structures and strategies
she deploys, with a particular emphasis on her use of the epistolary
method. The following chapter deals with her attention to the reading
of the moral message tangibly embodied in her educational writing. It
is followed by an analysis of the activity which earned her a reputation
as a learned woman. Various as the forms of her works are, they invariably
reflect her attempt to balance herself between the two demands of
inventiveness and familiarity
Survey Results of the New Health Care Worker Study: Implications of Changing Employment Patterns
No full textThis report examines the effects of contemporary employment arrangements on the quality of nursing work life, and the implications of these employment arrangements for individual nurses, the hospitals, and also for the organization. First we look at nurse work status (full-time, part-time or casual job), contract status (permanent or temporary), and employment preference as factors affecting commitment to the hospital and profession, job satisfaction, retention in the organization, and absenteeism from work. Second, we examine stress, burnout, and physical occupational health problems (in particular, musculoskeletal disorders), as affecting nurse and hospital outcomes. This project investigated how the quality of nursing worklife and career choices differ for nurses in full-time, part-time and casual employment, and whether nurses who have the employment arrangements they prefer enjoy a standard of worklife that encourages retention. We collected data for the study from 1,396 nurses employed at three large teaching hospitals in Southern Ontario (Hamilton Health Sciences, Kingston General Hospital, and St. Michael's Hospital in Toronto) using the New Health Care Worker Questionnaire. Results indicate that although a substantial majority of the nurses were employed in the type of job that they preferred, problems of stress, burnout and physical health problems were reported. Further, these problems affected the nurses' job satisfaction, commitment, and propensity to leave the hospitals.health care workers, employment status, nurses, job satisfaction, commitment, stress, burnout, physical health problems, MSD, propensity to leave
Variation in the carbon and nitrogen isotopic signatures of pig remains from prehistoric sites in the Near East and Central Europe
No full textThe first results of carbon and nitrogen (δ13C, δ15N) stable isotope analyses of domestic pig (Sus domesticus Erxl., 1777) remains from three prehistoric sites are presented. Of these, comparison of the datasets from Tell Aqab in Syria and Çamlıbel Tarlası in Turkey suggests different dietary patterns, and possibly different pig husbandry practices, at these sites. The study highlights the need for supporting evidence from archaeobotanical and palaeoenvironmental investigations in the interpretation of stable isotope data
Postprandial hepatic protein expression in trout Oncorhynchus mykiss a proteomics examination
No full textFollowing a meal, a series of physiological changes occurs in animals as they digest, absorb and assimilate ingested nutrients, the kinetics of these responses depends on metabolic rate and nutrient quality. Here we investigated the hepatic proteome in the ectothermic teleost, the rainbow trout, following a single meal to define the postprandial expression of hepatic proteins. The fish were fed a high marine fishmeal/fish oil single meal following a period of 24 h without feeding. Liver protein profiles were examined by 2D gel electrophoresis just before feeding (time 0 h) and at 6 and 12 h after feeding. Of a total of 588 protein spots analysed in a temporal fashion, 49 differed significantly in abundance between the three time groups (ANOVA, p<0.05), before and after feeding, 15 were increased and 34 were decreased in abundance after feeding. Amino acid metabolism-regulated proteins such as phenylalanine-4-hydroxylase and proliferating cell antigen were increased in abundance 12 and 6 h following the meal, suggesting by this time that the fish were increasing their protein turnover to utilize efficiently their dietary protein consumption. Overall, these results highlight some specificity of the trout metabolism and identify postprandial response of metabolism-related proteins 6–12 h after feeding a single meal. © 2016 The Author
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