104,397 research outputs found
Letter, [Author unclear] to Paulina T. Merritt
No full textHandwritten letter to Paulina Merritt from an unknown author, October 1, 1876.
Activity of an immobilized fungal laccase on phenolic compounds for wine stabilization
No full textThe goals of this study were to immobilize a fungal laccase by covalent attachment and by gel entrapment comparing their oxidative propertie
PROTECTIVE EFFECT OF 3-AMINOBENZAMIDE, AN INHIBITOR OF POLY (ADP-RIBOSE) SYNTHETASE, AGAINST STREPTOZOTOCIN-INDUCED DIABETES
No full textTHE ENDOCRINE CONTROL OF PEROXISOME FUNCTION - EFFECTS OF ANTILIPOLYTIC AGENTS ON RAT LIVER PEROXISOMES
No full textEffect of an antilipolytic drug on plasma insulin and glucagon concentrations in the rat
No full textThe accumulation of 2-deoxyglucose-6-phosphate activates glycogen synthase (and inactivates glycogen phosphorylase) in rat skeletal muscle
No full textIn the muscle loaded with 2-dGlc "in vitro" (this sugar is accumulated as hexosephosphate) glycogen synthase I levels are changed by a mechanism which is additive to those of hormones such as insulinor epinephrine. The levels of glycogen phosphorylase are decreased only at the highest 2-dGlc-6-P concentration. The role of this effect of sugar phosphate - which has been attributed to the activation of muscle phosphatase (6) - is discussed with regard to glycogen metabolism during muscle function
EFFECTS OF ANTILIPOLYTIC AGENTS ON RAT-LIVER PEROXISOMES AND PEROXISOMAL OXIDATIVE ACTIVITIES
No full textIdentificazione, in microscopia laser confocale, di uova di Trichuris trichiura in una mummia italiana del XVI secolo
No full textHandwritten biographical information on Paulina T. McClung Merritt
No full textA handwritten biography of Paulina T. McClung Merritt by an unknown author, 1892.
Heterogeneous and tissue-specific regulation of effector T cell responses by IFN-gamma during Plasmodium berghei ANKA infection.
No full textIFN-γ and T cells are both required for the development of experimental cerebral malaria during Plasmodium berghei ANKA infection. Surprisingly, however, the role of IFN-γ in shaping the effector CD4(+) and CD8(+) T cell response during this infection has not been examined in detail. To address this, we have compared the effector T cell responses in wild-type and IFN-γ(-/-) mice during P. berghei ANKA infection. The expansion of splenic CD4(+) and CD8(+) T cells during P. berghei ANKA infection was unaffected by the absence of IFN-γ, but the contraction phase of the T cell response was significantly attenuated. Splenic T cell activation and effector function were essentially normal in IFN-γ(-/-) mice; however, the migration to, and accumulation of, effector CD4(+) and CD8(+) T cells in the lung, liver, and brain was altered in IFN-γ(-/-) mice. Interestingly, activation and accumulation of T cells in various nonlymphoid organs was differently affected by lack of IFN-γ, suggesting that IFN-γ influences T cell effector function to varying levels in different anatomical locations. Importantly, control of splenic T cell numbers during P. berghei ANKA infection depended on active IFN-γ-dependent environmental signals--leading to T cell apoptosis--rather than upon intrinsic alterations in T cell programming. To our knowledge, this is the first study to fully investigate the role of IFN-γ in modulating T cell function during P. berghei ANKA infection and reveals that IFN-γ is required for efficient contraction of the pool of activated T cells
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