1,721,180 research outputs found
Epileptic nocturnal wanderings with a temporal lobe origin: A stereo-electroencephalographic study
No full textIs CEA better than CYFRA 21-1 in the monitoring of squamous cell lung cancer progression?
Full text linkEsperienze emozionali evocate dalla stimolazione elettrica intracerebrale del lobo temporale.
No full text[ATTO DI CONVEGNO
Assessment of personality and emotive profile in temporal drug-resistant epilepsy patients: A follow-up study.
No full textAnatomo-electro-clinical features of nocturnal epileptic motor behaviors and non-REM parasomnias: Data from intracerebral recordings
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Studio del profilo emotivo di soggetti con epilessia temporale farmaco-resistente in fase pre e post-chirurgica
No full textNeuropsychological outcome after paediatric temporal lobe surgery: Analysis of 6 cases [Outcome neuropsicologico del trattamento chirurgico dell'epilessia del lobo temporale in età pediatrica: Analisi di 6 casi]
No full textStereo-EEG-guided radio-frequency thermocoagulations of epileptogenic grey-matter nodular heterotopy
No full textObjective: To retrospectively evaluate seizure outcome in a case-series of patients with nodular heterotopy (NH)-related epilepsy treated by stereo-EEG (SEEG)-guided radio-frequency thermocoagulation (RF-THC) of the NH. Methods: Five patients (three male, age 5-33 years) with drug-resistant focal epilepsy presented a single NH at brain MRI. Following video-EEG monitoring, patients underwent SEEG recording to better identify the epileptogenic zone. All patients received RF-THC of the NH, using contiguous contacts of the electrodes employed for recording. The contacts for RF-THC lesions were chosen according to anatomical (intranodular position) and electrical (intranodular ictal low-voltage fast activity) criteria. Results: At SEEG recordings, ictal discharge originated from the NH alone in three cases and from the NH and ipsilateral hippocampus in one case. In the remaining case, different sites of ictal onset, including the NH, were identified within the left frontal lobe. No adverse effects related to the RF-THC procedures were observed, apart from a habitual seizure that occurred during coagulation in one patient. Postprocedural sustained seizure freedom was detected in four cases (mean follow-up 33.5 months). In the case with left frontal multifocal ictal activity, RF-THC of the NH provided no benefit on seizures, and the patient is seizure-free after left frontal lobe resection. Conclusions: SEEG-guided RF-THC proved to be a safe and effective option in our small case-series of NH-related focal epilepsy. The indications to this treatment were strictly dependent on findings of intracerebral recording by SEEG, which can define the role of the NH in the generation of the ictal discharge
RNASET2 as a tumor antagonizing gene in a melanoma cancer model
No full textThe RNASET2 gene, mapped in 6q27, was previously found to exert control of tumorigenesis in an ovarian cancer system. We present here results indicating a similar control in a melanoma cancer model. Thus, this gene is most likely involved in a common general pathway of tumorigenesis. Moreover, its antitumorigenic activity is manifested in vivo but not in vitro, suggesting that this gene belongs to the growing category of tumor antagonizing/malignancy suppressor genes. A possible role of RNASET2 in the activation of a senescence program, whose responsible locus was mapped in the same chromosomal 6q27 region, seems to be inconsistent with our data
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