3,499 research outputs found
Hepatopancreas is the extraovarian site of vitellogenin synthesis in black tiger shrimp, Penaeus monodon.
No full textPolymeric micelles and the Dy-166/Ho-166 generator: A study of the loading mechanism of Dy/Dy-166 and Ho-166 into PCL-b-PEO polymeric micelles for imaging and cancer treatment
No full textA radioisotope used in radionuclide therapy is Holmium-166 (Ho-166). The treatment effectiveness of Ho-166 could be improved by the use of a so called in vivo Dysprosium-166(Dy-166)/Ho-166 generator. The application of this generator is hindered by an effect called internal conversion (IC). This affect can arise after the decay of Dy-166 to Ho-166, which can cause separation of Ho-166 from its carrier.Polymeric micelles might form a solution in the application of the Dy-166/Ho-166 generator in radionuclide therapy. The main goal of this thesis was to investigate and understand the loading mechanism of metallic species and polymeric micelles with a focus on the loading of Dy/Dy-166 and Ho-166. It was found that it was not effective to load metallic species (Dy/Dy-166) as free ions or as solid precipitates. Loading metallic species as aqueous hydroxides showed to be crucial for achieving a good loading and high stability. The second goal was to study if polymeric micelles were able to retain Ho-166 inside their core under the effects of internal conversion. No additional losses of Ho-166 were found when Dy/Dy-166 and Ho-166 were loaded into the micelles. It was concluded that the PCL-PEO micelles prevented the loss of Ho-166 under internal conversion effects.Applied Science
Hepatopancreas and ovary are sites of vitellogenin synthesis as determined from partial cDNA encoding of vitellogenin in the marine shrimp, Penaeus vannamei.
No full textbeta-delayed proton decays and spin assignments for Tb-140, Dy-141 and Dy-143
No full textThe proton-rich isotopes Tb-140 and Dy-141 were produced via the fusion evaporation reaction Ca-40+ Cd-106. Their beta-delayed proton decays were studied by p-gamma coincidence in combination with a He-jet tape transport system, and half-lives, proton energy spectra, gamma-transitions following the proton emission, as well as beta-delayed proton branching ratios to the low-lying states in the grand-daughter nuclei were determined. Comparing the experimental data with statistical model calculations, the ground-state spins of Tb-140 and Dy-141 were found to be consistent with 7 and 9/2, respectively. The configuration-constrained nuclear potential energy surfaces (NPES) of Tb-140 and Dy-141 were calculated using the Woods-Saxon-Strutinsky method, which suggest the ground-state spins and parities of Tb-140 and Dy-141 to be 7(+) and 9/2(-), respectively. In addition, the configuration-constrained NPES of Dy-143 were calculated, which predict a 1/2(+) ground state and a 11/2(-) isomer with excitation energy of 198 keV. These findings are consistent with our previous experimental data on Dy-143 reported in Eur. Phys. J. A 16, 347 (2003).Physics, NuclearPhysics, Particles & FieldsSCI(E)3ARTICLE137-402
Direct numerical simulation of turbulent Couette-Poiseuille flow with zero skin friction
No full textThe near-wall scaling of mean velocity U(y) is addressed for the case of zero skin friction on one wall of a fully turbulent channel flow. The present DNS results can be added to the evidence in support of the conjecture that U is proportional to √yw in the region just above the wall at which the mean shear dU/dy = 0
Iron oxide nanoparticles as carriers for the Dy-166/Ho-166 in vivo generator: A study into the characteristics and retention of Dy and Ho in iron oxide nanoparticles
No full textBackground:Cancer is one of the leading causes of death worldwide. Targeted radionuclide therapy has become a important treatment, this is when a carrier molecule is attached to a radionuclide to deliver cytotoxic radiation levels to diseased cells. β− emitters are frequently used in RNT because they have a long penetration depth, such as the dysprosium-166/holmium-166 (166Dy/166Ho) in vivo generator. The 166Dy/166Ho in vivo generator shows great potential for large tumors because of the long half-life time of the mother nuclide 166Dy and the emission of high energy β− from the daughter nuclide 166Ho. Previous research shows the release of 72 % of the 166Ho when 166Ho is bound to conventional chelators due to internal conversion after the β− decay. The aim of this thesis is to synthesize an iron oxide nanoparticle as carrier for the 166Dy/166Ho in vivo generator. This iron oxide nanoparticles (SPIONs) should prevent internal conversion and thus the loss of the daughter nuclide 166Ho.Results:The dysprosium doped iron oxide nanoparticles were synthesized successfully with an average diameter of 6.1 ± 1.5 nm, measured with TEM. The DLS and TEM results showed that the SPIONs were aggregating. The labeling efficiency represents how much Dy is retained in the Dy doped SPIONs, for the non-radioactive Dy this was measured with the ICP/OES. The labelling efficiency was 3.21 ± 0.8 %. The 166Dy doped iron oxide nanoparticles were also synthesized successfully with a radiolabelling efficiency of 3.12 ± 2.2 %, measured with a 2480 Wizard 2 Gamma counter. The retention of 166Dy + 166Ho was 79.2 ± 1.8 % after 96 h.Conclusion:The retention of 166Dy + 166Ho in iron oxide nanoparticles was 79.2±1.8 % after 96 hours. This is much higher than the retention of 28% by conventional chelators. This means that the iron oxide nanoparticls is a safer carrier for the 166Dy/166Ho in vivo generator than the conventional chelator.Applied Physic
Carrier recombination processes and divalent lanthanide spectroscopy in YPO4:Ce3+;L3+ (L=Sm,Dy,Tm)
No full textWe studied charge carrier trapping, detrapping, and recombination phenomena in Ce3+ doped YPO4, codoped with Sm3+, Dy3+, or Tm3+. Ce ions trap the holes and Sm, Dy, and Tm trap electrons created during x-ray irradiation. By means of red to infrared stimulation, the trapped electrons can be back transferred to Ce leading to shorter wavelength Ce3+?5d-4f luminescence. Excitation spectra for this recombination luminescence were recorded from 10 K to room temperature. It provides information on the excited state energies of divalent Sm, Dy, and Tm with respect to the lanthanide ground state energy and with respect to the mobility edge energy of YPO4. From the temperature dependence, insight is obtained on the carrier recombination pathways. We will identify temperature independent tunneling recombination, recombination by thermal excitation to the conduction band, and phonon-assisted delocalization of electrons from impurity states within the conduction band.QN/Quantum NanoscienceApplied Science
Effective tumor therapy with plasmid-encoded cytokines combined with in vivo electroporation
No full textPlasmids may have unique advantages as a gene delivery system. However, a major obstacle is the low in vivo transduction efficiency. In this study, an electroporation-based gene transduction approach was taken to study the effect of interleukin (IL)-2 or IL-12 gene transduction on the growth of experimental murine tumors. Significant intratumoral gene transduction was achieved by electroporation of tumors that had been injected with naked plasmids encoding reporter genes and cytokine genes (IL-2 and IL-12) under the control of a constitutive cytomegalovirus promoter. In addition, significant tumor growth delay could be achieved in a murine melanoma line B16,F10 with the cytokine genes. Most importantly, systemic transgene levels were negligible when compared with intratumoral adenovirus-mediated IL-12 gene delivery, which leads to significantly higher systemic cytokine levels, Therefore, naked plasmid- and in vivo electroporation-mediated cancer gene therapy may be therapeutically efficacious while maintaining low systemic toxicity
Síntesis y caracterización de granates del tipo Sm3-xTRxFe5O12 (TR = Dy, Gd, Lu y La)
No full textLos granates de tierras raras (TR3Fe5O12) presentan propiedades magneto-eléctricas y ópticas que permiten su aplicación en transformadores, dispositivos de microondas y de almacenamiento de datos. Estas propiedades dependen de su estructura y morfología, que son altamente influenciadas por la sustitución parcial o total de los sitios catiónicos, así como por el método de síntesis. El presente trabajo se enfocó en la obtención de los nuevos granates de formula Sm3-xTRxFe5O12 (TR= Gd, Dy, Lu y La) con x=0.0, 0.1, 0.2, 0.4, 0.6, 0.8 y 1.0 sintetizados por los métodos citrato y cerámico, con el fin de evaluar la influencia del catión sustituyente y método sobre sus propiedades. La caracterización por DRX, Raman, MEB, EDX, VSM y medida de resistividad, demostró la adecuada sustitución del Sm por Lu, Dy y Gd favoreciendo la obtención de materiales de fase pura, de estructura cúbica y con grupo espacial Ia-3d (230). En contraste, el La llevó a la formación de fases de Sm1-xLaxFeO3 lo que se explica en función de su radio iónico. El método citrato favoreció la obtención de granates con partículas de menor tamaño ( 1 µm) y de carácter ferrimagnético, de mayor Hc y Ms menor en comparación con las muestras obtenidas por el método cerámico, con un tiempo y temperatura de calcinación menores en 18 h y 300 °C. Los resultados obtenidos permiten concluir que las muestras del sistema Sm3-xTRxFe5O12 (TR= Gd, Dy, Lu) presentan potenciales aplicaciones en transformadores y conmutadores de microondas, con una importante disminución en los costos de producción.Abstract. Rare earth garnets (TR3Fe5O12) have magneto-electric and optical properties that allow their application in transformers, microwave and data storage devices. These properties depend on their structure and morphology, which are influenced by the partial or total substitution of the cationic sites, as well as by the synthesis method. The present work focused in the obtaining of new garnets with formula Sm3-xTRxFe5O12 (TR = Gd, Dy, Lu and La) with x = 0.0, 0.1, 0.2, 0.4, 0.6, 0.8 and 1.0 synthesized by method citrate and ceramic method, in order to evaluate the influence of substituent cation and. Synthesis method on their properties. The characterization by XRD, Raman, MEB, EDX, VSM and resistivity measurement, demonstrated the adequate substitution of Sm by Lu, Dy and Gd favoring the obtaining of pure phase materials with cubic structure and space group Ia-3d (230). on the other hand, the substitution with La carried generated the formation of phases of Sm1-xLaxFeO3 which is explained according to its ionic radius. The citrate method favored the obtaining of garnets with particles of smaller size (1 μm), ferrimagnetic character, of higher HC and smaller MS compareted to the samples obtained by the ceramic method, with a calcination temperature and time even 300 °C and 18 h below. The results obtained allow to conclude that samples of the Sm3-xTRxFe5O12 system (TR = Gd, Dy, Lu) present potential applications in transformers and microwave switches, with a significant decrease in production costs.Maestrí
Study on Superdeformed Bands of Dy-152 and Its Neighboring Nuclei
No full textDy-152 is the first observed superdeformed nucleus, whose band structure reflects the typical distribution of high j low Omega orbitals of superdeformed nuclei in A similar to 150 mass region. The particle-number conserving treatment of the cranked shell model with monopole and quadrupole paring interactions is adopted to investigate the observed six superdeformed bands in Dy-152. The pi[523]7/2 orbital is emphasized for the first time to interpret the microscopic structure of band 2 and 3 of Dy-152. A new comprehension is proposed on the basis of ever existing experimental and theoretical results, and the reliability is illustrated by several superdeformed bands of neighboring nuclei.Physics, Fluids & PlasmasSCI(E)EI中国科学引文数据库(CSCD)05408-4111
- …
