1,722,835 research outputs found
Hybrid phenotypes and lineage promiscuity in acute leukemia
No full textClinical data indicate that AL are heterogeneous diseases with variable responsiveness to chemotherapeutic agents. Based on this evidence, the efforts of most investigators are aimed at providing rapid identification of AL features predictive of distinct prognostic outcomes. A considerable number of reagents (including MoAb and molecular probes) available from commercial sources has been widely used for diagnostic purpose, leading to the identification of "inappropriate" antigen expression and to diagnoses of "mixed" AL (M-AL). The latter still lacks adequate definition and identification criteria, but is frequently reported as a novel entity associated with poor clinical outcome. The use of more accurate methodologic approaches, as well as a better elucidation of normal hemopoietic cell characteristics suggest that true M-AL occur quite rarely: the features of normal precursor counterparts are more frequently conserved. "Ectopic" marker expression, however, which should not be interpreted as reflecting lineage infidelity, may in some instances explain different clinical courses in AL patients. Further elucidation of normal stem cell features, and adequate standardization of AL immunophenotyping--to be performed under proper technical conditions--are needed for a better evaluation of M-AL, both in terms of diagnosis and classification, as well as regarding their clinical significance
Additive effects in the induction of apoptosis in leukemic cells by WT1 and BCR-ABL specific siRNA
No full textBody cavity lymphoma.
No full textBody cavity lymphomas (BCLs) are a heterogeneous group of rare, primary non-Hodgkin's lymphomas that proliferate within the serous body cavities and result in recurrent effusions. This review is mainly focussed on the distinct entity primary effusion lymphoma (PEL) wherein the tumor clone is infected by human herpesvirus-8, the etiologic agent of Kaposi's sarcoma. In addition, we briefly discuss here recent data regarding other BCL types. The latter include a subset with no evidence of herpesvirus 8 which is associated with Epstein-Barr virus (pyothorax-associated lymphoma, PAL), the BCL forms associated to hepatitis C virus-related cirrhosis or alcohol-related cirrhosis and, finally, non-neoplastic forms mimicking lymphomatous effusions
POST-TRAUMATIC STRESS DISORDER: A FREQUENT WORK-RELATED ILLNESS
Full text linkPost-traumatic stress disorder (PTSD) is an anxiety disorder that results from exposure to a traumatic event, and is characterized by hypermnesia of the traumatic event with frequent re-experiencing of the tragic occurrence, hyperarousal, and avoidance behaviour. Depression, anxiety, sleep dysfunction and substance abuse are also commonly reported. PTSD is highly prevalent both in the general population and in certain occupations that are particularly exposed to life-threatening situations, physically and psychological demanding activities, and physical assault, such as rescue workers, firefighters and paramedics. Recent advances in the comprehension of the epidemiology, physiopathology and clinical presentation of PTSD could push toward increased identification of this common psychiatric disorder with significant reflections on the chances of successful treatmen
Acute myeloid leukemia developing in patients with autoimmune diseases.
Full text linkAcknowledgments: the authors gratefully acknowledge the generous support of Dr. Isabel Cunningham, for her intellectual input and editorial assistance. The authors would also like to thank Dr. Gabriele Mazzitelli, Tor-Vergata Digital Library, for his prompt response in providing the original full text of the reviewed literature. Prof. F. Lo-Coco acknowledges the support from the AIL and AIRC
, Un semplice metodo grafico per ottimizzare la scelta del pH al quale eseguire una titolazione complessometrica con indicatore metallocromico
No full textClinical usefulness of arsenic trioxide in the treatment of acute promyelocytic leukemia
No full textDiagnostic and prognostic advances in the immunophenotypic and genetic characterization of acute leukaemia
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