19,913 research outputs found
TACC3-ch-TOG track the growing tips of microtubules independently of clathrin and Aurora-A phosphorylation
Full text linkThe interaction between TACC3 (transforming acidic coiled coil protein 3) and the microtubule polymerase ch-TOG (colonic, hepatic tumor overexpressed gene) is evolutionarily conserved. Loading of TACC3–ch-TOG onto spindle microtubules requires the phosphorylation of TACC3 by Aurora-A kinase and the subsequent interaction of TACC3 with clathrin to form a microtubule binding surface. Whether there is a pool of TACC3–ch-TOG that is independent of clathrin in human cells, and what is the function of this pool, are open questions. Here, we report that TACC3 is recruited to the plus-ends of microtubules by its association with ch-TOG and that this pool is independent of phosphorylation and binding to clathrin. The plus-end binding of TACC3–ch-TOG persists in interphase and we propose that one cellular function of TACC3–ch-TOG is to modulate cell migration. We also describe the distinct subcellular pools of TACC3, ch-TOG and clathrin. TACC3 is often described as a centrosomal protein, but we show that there is no significant population of TACC3 at centrosomes. The delineation of distinct protein pools reveals a simplified view of how these proteins are organized and controlled by post-translational modification
Notes sur les Lo-Lo du Kien-Tchang
No full textFrançois Ch. Notes sur les Lo-Lo du Kien-Tchang. In: Bulletins et Mémoires de la Société d'anthropologie de Paris, V° Série. Tome 5, 1904. pp. 637-647
Ar-40-Ar-39 thermo chronological constraints on the exhumation of ultrahigh-pressure metamorphic rocks in the Sulu terrane of eastern China
No full textA new picorna-like virus, PnPV, isolated from Ficus transparent wing moth, Perina nuda (Fabricius).
No full textCharacterization of a multiple-nucleocapsid nucleopolyhedrovirus isolated from Perina nuda (Fabricius) (Lepidoptera: Lymantriidae) larvae.
No full textViral interference in to-2 cells infected with IPN virus isolated from clam, Meretrix-lusoria.
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Ultrastructure of white spot syndrome virus development in primary lymphoid organ cell cultures.
No full textMolecular cloning and nucleotide sequences of the Perina nuda nucleopolyhedrovirus (PenuNPV) p10 gene.
No full textIn vitro phagocytosis of occlusion bodies of nucleopolyhedroviruses by insect cell lines.
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