614 research outputs found
Calling large indels in 1047 Arabidopsis with IndelEnsembler
No full text10.1093/nar/gkab904NUCLEIC ACIDS RESEARCH491910879-1089
Design and build portable fixed-wing VTOL aircraft with autonomous capability
No full textUnmanned Aerial Vehicle (UAV) has been around for years and was used extensively in Aerial Filming, Mapping & Inspection. However, the capabilities of the UAV are often limited by the type of aircraft and the specialized skills required to pilot the UAV. They are generally categorized into two different groups, namely Rotary Wing (Multirotor) and Fixed-Wing. Multirotors under the Rotary Wing are generally precise in missions with Vertical Take-Off and Landing (VTOL) capabilities. However, it is less efficient due to the lift generated primarily from its rotors, resulting in a shorter range and endurance. Conversely, Fixed-Wing UAV generates its lift from its wing profile which enables the aircraft to fly further and longer. In spite of the operational advantages, it requires a sufficiently large and empty space for Conventional Take-Off and Landing (CTOL). Furthermore, Fixed-Wing UAV is generally larger and not able to be broken down into components which could result in assembly and portability issues. This has severely limited its operational capabilities such as a dense plantation. The innovative combination of both Vertical Take-off and Landing capability of Multirotor and the Long-Range of Fixed-Wing aircraft system is initiated. It enhances the performance of the UAVs in various ways such as the ability to hover, to transit between flight modes, high speed, long range, long endurance flight and to provide effective reconnaissance and support in time-critical situations.Bachelor of Engineering (Aerospace Engineering
Discrete space-based route planning for rotary-wing UAV formation in urban environments
No full textThe route planning problem for rotary-wing UAV formation is studied in discrete urban environments. First, a discrete-space consensus algorithm (DSCA) integrating asynchronous planning and grouping mechanism is developed to make the rotary-wing UAVs converge to the desired formation. Then the DSCA is combined with the improved rapidly-exploring random tree (IRRT) algorithm to enable the rotary-wing UAV formation to avoid the obstacles. Finally, the time information of waypoints is complemented by resolving the conflicts among multiple rotary-wing UAVs, thus reducing the rotary-wing UAVs' time gap of reaching the destinations. The proposed method extends the original consensus theory in the discrete space and for the obstacle avoidance issue. Also, it is valid in the route planning problem for rotary-wing UAV formation considering the real urban environments.Ministry of Education (MOE)This research work is supported by the Chongqing Research Program of Basic Research and Frontier Technology, China (grant number of cstc2020jcyj-msxmX0602) and the Fundamental Research Funds for the Central Universities, China (grant number of 2020 CDJ-LHZZ-066). Thanks are also due to China Scholarship Council (project reference number 201906055030) for the financial support of the research attachment of the first author to the ATMRI in the NTU, Singapore. This collaborative research, findings presented, and interactions among teams are also relevant to the Ministry of Education (MOE, Singapore) Tier-1 project research grant (Project ID: 2018-T1-002-124) and the UAS Program on ‘‘Urban Aerial Transport Traffic Management and Systems’’ in the ATMRI, NTU, Singapore. The current work also provides the basis and idea for the recently approved National Natural Science Foundation of China (grant number of 52102453)
Coordinative conjunctions in Chinese dialects : a typological study
No full textWu (2003) investigated a number of coordinative conjunctions and stated that the coordinative conjunctions in Chinese were developed through the grammaticalization path: verb > comitative preposition > coordinative conjunction. Liu and Peyraube (1994) studied the historical texts from pre-Qin to Song Dynasties and they reached the same conclusion as Wu (2003). Liu (2003), however, argued that the coordinative conjunction taʔ 5搭 in the Wu dialect was grammaticalized directly from the verb. Despite that research has been carried out to investigate the use of coordinative conjunctions in Chinese dialects and classical Chinese, none of the previous research mentioned the situation in the Yue dialect. This present research aims at reconstructing the grammaticalization path of the coordinative conjunctions in several varieties of Yue as spoken in the Guangdong Province. The grammaticalization processes observed in Yue are to be compared with those in other Chinese dialects.Three findings are obtained in this study (i) The coordinative conjunctions in Guangdong Yue were developed from two possible grammaticalization paths, of which Path II is not observed in other Chinese dialects. Path I: verb > comitative preposition > coordinative conjunction (for animate nouns) > coordinative conjunction (for all nouns) > coordinative conjunction (for all nouns and adjectives) Path II: verb > coordinative conjunction (for adjectives) > coordinative conjunction (for all nouns and adjectives) (ii) For those lexical items from which the coordinative conjunctions in Chinese dialects were developed, there is a tendency that they share similar semantic properties, named as ‘physical proximity’, and (iii) two implicational hierarchies were observed in Chinese dialects, namely comitative > allative > ablative > locative, and comitative > allative > benefactive.</p
Rethinking the mechanism of the social impact assessment with the ‘right to the city’ concept: a case study of the Blue House Revitalization Project in Hong Kong (2006–2012)
No full textThis is the author accepted manuscript. The final version is available from Taylor & Francis (Routledge) via the DOI in this record.Over the past two decades, urban renewal has become a major means to increase the efficiency of land production in Hong Kong (HK). Although the Urban Renewal Authority (URA) and Hong Kong Housing Authority (HKHA) have introduced the social impact assessment (SIA) mechanism to mitigate the social impact of renewal projects, social conflicts have intensified between affected residents and the URA/HKHA. To what extent can SIA effectively mitigate the social impacts of urban renewal in HK? To answer this question, the author draws on a mixture of empirical and secondary materials to analyse the development, assessment procedures, and report format of SIA in HK as a basis to evaluate the challenges of this mechanism. Then the author goes on to critically analyse how thinking on ‘right to the city’ and affected residents’ comments come together to inform reflections on SIA in HK. The author argues that the SIA mechanism in HK remains technocratic in nature because it does not function effectively in addressing the needs of affected residents and resolving the deep-rooted conflicts between residents’ right of living and pro-growth development
An implementation of form-oriented applications software development
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Robotic insect
No full textThis thesis was scanned from the print manuscript for digital preservation and is copyright the author.
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Kin-state diaspora politics: Serbian and Hungarian diaspora policy case studies
No full textAutore maģistra darbā Etniskās dzimtenes īstenotā diasporas politika: Serbijas un Ungārijas diasporu politikas gadījumu analīze apskata diasporas politiku un tās lomu starpvalstu attiecību veidošanā. Pētījums ir balstīts uz Serbijas un Ungārijas diasporas politikas analīzi pēc 1989. gada.
Analizējot diasporas politiku un partiju ideoloģiskās piederības lomu aktīvas diasporas politikas īstenošanā, autore secina, ka aktīvāka diasporas politika tiek īstenota laikā, kad pie varas ir labējā spārna partijas.
Darbā autore analizē Serbijas attiecības ar Horvātiju un Slovēniju, Ungārijas attiecības ar Slovākiju un Rumāniju diasporas politikas kontekstā, secinot, ka negatīvi tiek vērtēta vienpusēji īstenota diasporas politika, kas sniedzas ārpus kultūras un identitātes stiprināšanas jomas.In the paper Kin-state diaspora politics: Serbian and Hungarian diaspora policy case studies for Master’s degree the author analyzes diaspora politics and its role in inter-state relations. The research paper is based on the Serbian and Hungarian diaspora policy case studies after 1989.
Analysing the diaspora policy and the role of the ideologies of political parties in the implementation of active diaspora policy, the author concludes that a more active diaspora policy is implemented at a time when right-wing parties are in power.
The author analyzes Serbia's relations with Croatia and Slovenia, Hungary's relations with Slovakia and Romania in the context of diaspora policy. The author concludes that a unilaterally implemented diaspora policy is evaluated negatively, if the diaspora policy includes broader objectives than the strengthening of culture and identity
Radiological tracking of lung cancer metastases from relapse to death using longitudinal imaging and ctDNA
No full textMetastatic non-small cell lung cancer (NSCLC) shows significant heterogeneity in clinical progression and treatment response. The prognostic impact of the distribution and growth dynamics of metastases from relapse to death remains poorly understood. Characterising these patterns on a lesion level may reveal the biological mechanisms underlying metastatic growth.
Longitudinal 3D volumetric data was compiled for 704 metastases, alongside multi-region sequencing from primary and metastatic tumours from 151 patients with early-stage NSCLC who relapsed after surgical resection in the TRACERx (TRAcking Cancer Evolution through therapy (Rx) and PEACE (Posthumous Evaluation of Advanced Cancer Environment) studies. I integrated radiological data with tumour genomics to uncover genomic and transcriptomic features driving metastatic dissemination and treatment resistance. Additionally, I explored the clinical utility of circulating tumour DNA (ctDNA) as a marker for tracking changes in tumour volume during the disease course.
I observed that the anatomical nature of metastatic disease progressed from relapse to death in distinct temporal patterns. Extrathoracic metastases, including bone, liver, and adrenal glands emerged later in the disease course and were associated with poor prognosis. Despite significant heterogeneity in lesion growth rates within patients, rapid metastatic growth at first relapse was associated with poor prognosis. Transcriptomic and genomic features of the primary tumour, including proliferation, immune suppression, and chromosomal instability (CIN) were associated with rapid metastatic growth. A mixed response to treatment was associated with worse prognosis and extrathoracic metastases demonstrated lower response rates than intrathoracic metastases, potentially due to higher CIN in the metastasis. ctDNA tracked with the total metastatic burden for most patients, with liver metastases showing the highest ctDNA shedding per unit of tumour volume, suggesting organ-specific differences in ctDNA release.
By integrating longitudinal imaging with genomic, transcriptomic, and ctDNA analyses I provide real-world insights into the molecular features that underpin phenotypic lesion-specific heterogeneity in metastatic NSCLC
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