5,102 research outputs found

    Space-time codes with full antenna, diversity using weighted nonbinary repeat-accumulate codes

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    Like turbo codes, repeat-accumulate codes have remarkably good performance when r greater than or equal to 3, where r is the number of repetition times. In this letter, we present space-time codes with full antenna diversity using "weighted" nonbinary repeat-accumulate codes. Compared with the space-time turbo codes in Liu et al. and So et al., the main advantage of this new scheme is to construct space-time codes with full diversity for any m less than or equal to r and any length of frame without searching for interleavers, where m is the number of transmit antennas. These space-time codes have rate m/r and so, have full rate when m = r. Furthermore, they have an efficient decoding based on the message passing algorithm.X113sciescopu

    KC-180‑2 Exerts Anti-SCLC Effects via Dual Inhibition of Tubulin Polymerization and Src Signaling

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    In this study, a series of N-benzyl-2-(5-phenylpyridin-2-yl) acetamide-based derivatives were successfully designed and synthesized as anti-cancer agents. KC-180-2 was screened as a potentially leading compound with dual mechanisms of action: Src signaling and tubulin polymerization inhibition. It efficiently suppressed the proliferation of five cancer cell lines (MDA-MB-231, H446, SKOV-3, HepG2, and HT29), with IC50 values ranging from 5 to 188 nM, especially small-cell lung cancer (SCLC) cells (IC50, 5 nM). Correspondingly, it exerted a significant therapeutic effect on the H446 small-cell lung cancer xenograft model, significantly reducing the volume of tumors without obvious toxicity. Mechanistically, this compound significantly inhibited the polymerization of purified tubulin in vitro, inducing G2/M cell cycle arrest and binding to the kinase catalytic domain of the Src protein, which reduced the phosphorylation of Src. Thus, KC-180-2 is a potential lead compound for the further development of a new anti-tumor drug against SCLC

    sj-docx-1-nms-10.1177_14614448221099173 – Supplemental material for Hashtag activism in a politicized pandemic: Framing the campaign to include Taiwan in the World Health Organization’s efforts to combat COVID-19

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    Supplemental material, sj-docx-1-nms-10.1177_14614448221099173 for Hashtag activism in a politicized pandemic: Framing the campaign to include Taiwan in the World Health Organization’s efforts to combat COVID-19 by Anita KC Liu, Yotam Ophir, Shu-An Tsai, Dror Walter and Itai Himelboim in New Media & Society</p
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