1,721,110 research outputs found
Traumatic extrusion of the talus-delayed re-implantation with autologous bone marrow mononuclear cell addition: A case report
No full textno abstract availabl
Comparison of cytologic composition with microfluorometric DNA analysis of the glioblastoma multiforme and anaplastic astrocytoma.
No full textFunctional assessment of human mesenchymal stem cells grown in hyaluronic acid scaffolds-biomechanics
No full textProliferation and collagene type I expression of osteoarthritic osteoblasts are induced by CXCL12 (SDF-1) and CXCL13 (BCA-1) chemokines
No full textBiomaterials: Foreign bodies or tuners for the immune response?
Full text linkThe perspectives of regenerative medicine are still severely hampered by the host response to biomaterial implantation, despite the robustness of technologies that hold the promise to recover the functionality of damaged organs and tissues. In this scenario, the cellular and molecular events that decide on implant success and tissue regeneration are played at the interface between the foreign body and the host inflammation, determined by innate and adaptive immune responses. To avoid adverse events, rather than the use of inert scaffolds, current state of the art points to the use of immunomodulatory biomaterials and their knowledge-based use to reduce neutrophil activation, and optimize M1 to M2 macrophage polarization, Th1 to Th2 lymphocyte switch, and Treg induction. Despite the fact that the field is still evolving and much remains to be accomplished, recent research breakthroughs have provided a broader insight on the correct choice of biomaterial physicochemical modifications to tune the reaction of the host immune system to implanted biomaterial and to favor integration and healing
NUOVE MOLECOLE PER LA RIGENERAZIONE TISSUTALE OSSEA
No full textLa presente invenzione ha per oggetto nuovi composti per il trattamento
dell’osteoporosi e in generale delle patologie ossee caratterizzate da una
progressiva perdita di massa ossea, ad esempio artrite reumatoide,
iperparatiroidismo, metastasi tumorali ossee
Bone regeneration improves with mesenchymal stem cell derived extracellular vesicles (Evs) combined with scaffolds: A systematic review
No full textScaffolds associated with mesenchymal stem cell (MSC) derivatives, such as extracellular vesicles (EVs), represent interesting carriers for bone regeneration. This systematic review aims to analyze in vitro and in vivo studies that report the effects of EVs combined with scaffolds in bone regeneration. A methodical review of the literature was performed from PubMed and Embase from 2012 to 2020. Sixteen papers were analyzed; of these, one study was in vitro, eleven were in vivo, and four were both in vitro and in vivo studies. This analysis shows a growing interest in this upcoming field, with overall positive results. In vitro results were demonstrated as both an effect on bone mineralization and proangiogenic ability. The interesting in vitro outcomes were confirmed in vivo. Particularly, these studies showed positive effects on bone regeneration and mineralization, activation of the pathway for bone regeneration, induction of vascularization, and modulation of inflammation. However, several aspects remain to be elucidated, such as the concentration of EVs to use in clinic for bone-related applications and the definition of the real advantages
Mechano-functional assessment of human mesenchymal stem cells grown in three-dimensional hyaluronan-based scaffolds for cartilage tissue engineering.
No full textHistological and immunohistochemical analysis of an allogenic bone graft engineered with autologous bone marrow mononuclear cells in the treatment of a large segmental defect of the ulna. A case report.
No full textP167 Rationale for the use of tissue engineering in early cartilage lesions in osteoarthritis
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