1,417 research outputs found
Draft Article with suggested Edits "The People Versus Frank Smiley: Investigating an 1894 Sodomy Crime in Territorial Utah"
No full textText document "The People Versus Frank Smiley: Investigating an 1894 Sodomy Crime in Territorial Utah" article written by Randell Hoffman, proof read and edit suggestions by Connell "Rocky" O\u27Donovan. gives back grounds of Frank Smiley\u27s arrest and detention for "Buggary" for his relations with Willis Clark. LGBTQ History through arrest records.Converted from .docx to .pdf for compatibilit
My Reflections on Connell
No full text\ua9 The Author(s).I have carried Connell\u27s work with me as I have embarked on a career within human geography with specialist interest in gender and generation. Although my empirical lens has shifted and expanded in different ways and at different times, those same theoretical underpinnings have remained in place. I found myself returning to Connell\u27s work on The Men and The Boys in my most recent academic work, namely through a "young dads and lads"project. Particularly noteworthy are the ways in which these young men move (and are moved by others) in between "boyhood, ""manhood, "and back again. Connell\u27s work helps me understand how processes of childhood socialization gendered these boys, and how as young men they are gendered still through processes of fatherhood. Iam left questioning what is left behind when boys become men. I also am left needing to thank Raewyn for my lectureship - perhaps these reflections will go some way toward doing so
Biographical notes on Bonnie Alice Christensen
No full textText Document lisa evans interview notes and biographical information on Bonnie Alice ChristensenConverted from .docx to .pdf for compatibilit
Biographical notes on Charles Warren Stoddard
No full textText document Queer Author visits Utahconverted from .docx to .pdf for compatibilit
Rereading gender in Sally Rooney’s novel normal people: an analysis of connell waldron as a 21st century redefinition of masculinity
No full text[eng] The best-selling novel Normal People (2018), written by the Irish author Sally Rooney, has
engaged readers through its intricate portrayal of youngsters in Ireland and the dynamics of
coming-of-age relationships. This literary work follows the lives of Marianne Sheridan and
Connell Waldron from their small town of Carricklea to their entrance into adulthood in urban
Dublin. Through a close reading of the text, this thesis delves into Rooney’s portrayal of
Connell’s masculinity and the different stages he goes through in his life: from a young boy
who perpetuates traditional masculine traits to a young adult who is characterised by his
empathy and vulnerability. This analysis will be carried out through the lens of “gender
performativity”, discussed by Judith Butler, “hegemonic masculinity” as theorised by Raewyn
Connell, and what Michael Foucault perceives as “power discourses”. This dissertation will
explore the impact of personal relationships along with societal pressures in shaping Connell
Waldron’s identity. By its redefinition of masculinity, Normal People contributes to broader
conversations about complex identities, challenging traditional gender roles and offering a
critique of twenty-first-century societal expectations
Jonathan F. Krell. Ecocritics and Ecoskeptics: A Humanist Reading of Recent French Ecofiction. Liverpool UP, 2020.
No full textReview of Jonathan F. Krell. Ecocritics and Ecoskeptics: A Humanist Reading of Recent French Ecofiction. Liverpool UP, 2020, 261 pp
Ms King and Mr O 'Connell, 1987
No full textPhotograph originally appeared in the 'Swinburne Newsletter', 2nd July 1987. Left Ms Lisa King, Arts Degree student and Mr Kevin O'Connell, Arts Degree student , President Student Union. Ms King and Mr O'Connell are standing as candidates for the Senate in the July 11th 1987 Federal Election
sj-docx-1-vet-10.1177_03009858231171906 – Supplemental material for Hepatic proinflammatory myeloid phenotypes are a hallmark of Ebola virus Kikwit pathogenesis in rhesus monkeys
No full textSupplemental material, sj-docx-1-vet-10.1177_03009858231171906 for Hepatic proinflammatory myeloid phenotypes are a hallmark of Ebola virus Kikwit pathogenesis in rhesus monkeys by Anna E. Tseng, Mariano Carossino, Hans P. Gertje, Aoife K. O�Connell, Suryaram Gummuluru, Vijaya B Kolachalama, Udeni B. R. Balasuriya, John H. Connor, Richard S. Bennett, David X. Liu, Lisa E. Hensley and Nicholas A. Crossland in Veterinary Pathology</p
Establishment of hedgehog pathway overexpression in osteosarcoma cell lines leading to an anti-apoptotic genotype which can be inhibited by the common anti-fungal and hedgehog pathway inhibitor, itraconazole
No full textOsteosarcoma (OS) is the most common primary bone cancer in dogs, yet therapies for pets with metastatic OS remain clinically ineffective. With the advent of precision medicine, strong scientific and clinical impetus exists to further investigate druggable molecular perturbations that might contribute to canine OS pathology. Dysregulated activity of the hedgehog (HH) pathway has been identified in diverse cancers in people and animals and leads to overexpression of anti-apoptotic proteins including Bcl-2 and c-FLIP. This produces an anti-apoptotic genotype by influencing both the intrinsic and extrinsic arms of the apoptotic pathway. Itraconazole is an antifungal agent that has been found to inhibit Smoothened (SMO), a crucial G protein-coupled receptor located on the cell membrane and becomes activated on the primary cilium, which allows initiation of HH pathway signaling. We hypothesize that components of the HH pathway are overexpressed in canine OS cell lines with concurrent downstream anti-apoptotic factor overexpression relative to non-malignant osteoblasts. Additionally, itraconazole would inhibit HH pathway signaling by promoting SMO relocation off the primary cilium.
RNA transcript and protein expressions of SMO, Bcl-2 and c-FLIP were characterized in three canine OS cell lines and normal canine osteoblast cultures. The IC50 concentrations of itraconazole in OS cell lines were determined, and itraconazole’s effects on the HH pathway signaling partners were evaluated at RNA and protein levels. Confocal microscopy was utilized to confirm the modulation of protein levels after treatment with itraconazole. In addition, the effect of the combinations of itraconazole and commonly used cytotoxic agents, doxorubicin and carboplatin, were explored with regard to cell death. This data was used to assess the tolerability of itraconazole in combination with these chemotherapeutics in a murine model which was then used to explore the effects of itraconazole with or without cytotoxic agents on a metastatic osteosarcoma model.
OS cell lines overexpress SMO, Bcl-2, and c-FLIP relative to normal osteoblasts. The IC50 of itraconazole in OS cells ranged from 490-790 nM. Itraconazole effectively perturbs protein expressions of the HH signaling pathway and downstream targets. The combination of itraconazole with carboplatin and itraconazole with doxorubicin was found to be synergistic compared to agents alone with regard to cell death. The combination of cytotoxin and itraconazole was found to be tolerable in mice with no cumulative toxicity.
SMO and Bcl-2 are overexpressed in OS cells and itraconazole can disrupt the HH signaling pathway at biologically relevant concentrations, warranting further investigation of itraconazole as adjuvant therapy for OS.Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2023-05-01The student, Dana Connell, accepted the attached license on 2020-11-02 at 19:08.The student, Dana Connell, submitted this Thesis for approval on 2020-11-02 at 20:00.This Thesis was approved for publication on 2020-11-18 at 12:01.DSpace SAF Submission Ingestion Package generated from Vireo submission #15854 on 2021-09-16 at 17:01:23Made available in DSpace on 2021-09-17T02:34:08Z (GMT). No. of bitstreams: 2
CONNELL-THESIS-2021.pdf: 19956003 bytes, checksum: 064479b56f45d3d97352ed353da6f636 (MD5)
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Previous issue date: 2020-11-18Embargo set by: Seth Robbins for item 118456
Lift date: 2023-09-17T02:34:57Z
Reason: Author requested U of Illinois access only (OA after 2yrs) in Vireo ETD systemAuthor requested U of Illinois access only (OA after 2yrs) in Vireo ETD systemU of I Onl
The Salience of Hegemonic Masculinity
No full textThis article argues that the concept of “hegemonic masculinity” remains highly salient to critical masculinities studies. The author outlines Raewyn Connell\u27s initial formulation of the concept, how that initial model of hegemonic masculinity has been historically misinterpreted, the reformulation of the concept by Connell and Messerschmidt, and the recent scholarly amplification of the concept. The author concludes that Connell’s original emphasis on the legitimation of unequal gender relations remains essential to both the concept and to the field of critical masculinities studies
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