164 research outputs found
Abstract ED02-03: Gaining epidemiologic insights from ancestry associations with cancer risk factors.
No full text
Transethnic genome-wide association study of colorectal cancer identifies a new susceptibility locus in VTI1A
No full textAbstract
To identify genetic variants that contribute to colorectal cancer (CRC) susceptibility, we performed a meta-analysis of two genome-wide association studies in 2,627 cases and 3,797 controls of Japanese ancestry and 1,894 cases and 4,703 controls of African ancestry, followed by a replication of genome-wide statistically significant associations (P < 5E-8) in 16,823 cases and 18,211 controls of European ancestry. This study revealed a new pan-ethnic CRC risk locus at 10q25 (rs12241008, intronic to VTI1A; P=1.5E-9), providing additional insight into the etiology of CRC and highlighting the value of association mapping in diverse populations.
Citation Format: Hansong Wang, Terrilea Burnett, Suminori Kono, Christopher Haiman, Motoki Iwasaki, Lynne Wilkens, Lenora Loo, David Van Den Berg, Laurence Kolonel, Brian Henderson, Temitope Keku, Robert Sandler, Lisa Signorello, William Blot, Polly Newcomb, Mala Pande, Christopher Amos, Dee West, Stéphane Bézieau, Sonja Berndt, Brent Zanke, Li Hsu, Noralane Lindor, Robert Haile, John Hopper, Mark Jenkins, Steven Gallinger, Graham Casey, Stephanie Stenzel, Fredrick Schumacher, Ulrike Peters, Stephen Gruber, Shoichiro Tsugane, Dan Stram, Loic Le Marchand. Transethnic genome-wide association study of colorectal cancer identifies a new susceptibility locus in VTI1A. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr LB-282. doi:10.1158/1538-7445.AM2014-LB-28
Adult weight gain and diabetes among African American and White adults in southeastern US communities
No full textTo examine associations between adult weight gain and diabetes among African Americans and whites
Reconciling the Evidence on Serum Homocysteine and Ischaemic Heart Disease: A Meta-Analysis
No full textThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
Abstract B75: Racial differences in <i>Helicobacterpylori</i> infection in the southeastern United States
No full textAbstract
Context: Gastric cancer incidence in African Americans is twice that in whites, and differing prevalence of strain-specific Helicobacter pylori infection may explain the disparity.
Objective: To investigate if there are racial differences in Helicobacter pylori infection.
Design, Setting, and Participants: The Southern Community Cohort Study recruited 86,000 participants, two-thirds African American, from 12 southeastern states from 2002-2009. Serum levels of antibodies to Helicobacter pylori proteins were assessed for a sample of 712 African American and non-Hispanic white participants using multiplex serology. Sero-positivity to each Helicobacter pylori protein was defined by predetermined cut-points based on median reporter fluorescence intensity. African and European admixture was estimated using a panel of 276 ancestry genetic markers, with “low,” “medium,” and “high” categories of African ancestry defined as &lt;85%, 85-95%, and ≥95%.
Main Outcome Measures: Odds ratios (ORs) for sero-positivity to antibodies to Helicobacter pyloriproteins, by race and African ancestry.
Results: In this sample of low-income African Americans and whites, 88% of African Americans and 69% of whites were sero-positive for Helicobacter pylori. Being African American, compared to being white, was associated with a 2- to 6-fold increased risk for sero-positivity to 8 of 15 Helicobacter pylori proteins examined, including CagA (OR, 5.88; 95% CI, 4.21 −8.22), and VacA (OR, 2.70; 1.96-3.72), previously established as virulence factors for gastric cancer risk. Compared to whites, African Americans of low, medium, and high African ancestry had 1.5-, 4.1 -, and 5.0-fold increased risks of sero-positivity to Helicobacter pylori, respectively, primarily related to CagA+ strains, for which increasing African ancestry led to 2.7-, 8.7-, and 12.3-fold increased risks, respectively (all Pfor trend &lt;0.0001).
Conclusions: African American race and increasing percentage of genetic estimation of African ancestry are strongly associated with prevalence of infection with Helicobacter pylori, particularly its virulent strains.
Citation Information: Cancer Epidemiol Biomarkers Prev 2010;19(10 Suppl):B75.</jats:p
Sedentary behaviors among females [adjusted mean (std err)] across demographic characteristics and body mass index, by race<b>.</b>
No full text1<p>Includes total/occupational activity plus sports/exercise.</p>2<p>Wake time includes sitting, household/occupational activity, and sports.</p><p>NOTE: All models are adjusted for the other demographic characteristics shown in the table as well as for hypertension (Y/N), diabetes (Y/N), heart attack/coronary artery disease (Y/N), stroke/TIA (Y/N), and emphysema (Y/N).</p
Association Between Socioeconomic Status (SES) and Lower Urinary Tract Symptom (LUTS) Severity Among Black and White Men
No full text- …
