285 research outputs found
T.J. Stiles: “The Commodore’s Patriotism: Cornelius Vanderbilt’s Path to the Founding of Vanderbilt University”
No full textIncludes descriptive metadata provided by producer in MP4 file: "Chancellor's Lecture Series - Videos - T.J. Stiles: 'The Commodore’s Patriotism: Cornelius Vanderbilt’s Path to the Founding of Vanderbilt University'." By Vanderbilt University. T.J. Stiles, Pulitzer Prize-winning author and historian, speaks Sept. 29, 2010 as part of the Chancellor's Lecture Series. Stiles wrote the 2009 biography The First Tycoon: The Epic Life of Cornelius Vanderbilt. Chancellor Nicholas Zeppos introduces Stiles. Stiles takes questions after his lecture
Cwbr Author Interview: Custer\u27s Trials: A Life On The Frontier Of A New America
No full textInterview with T.J. Stiles, author of Custer\u27s Trials: A Life on the Frontier of a New America Interviewed by Tom Barber
Civil War Book Review (CWBR): The Civil War Book Review is pleased to speak with T.J. Stiles, winner of multiple awards for biography and author of Jesse James: Last Rebel of the Civil War and The First Tycoon: The Epic Life of Cornelius Vanderbilt. Today we get to discuss his most recent work Custer\u27s Trials: A Life on the Frontier of a New America. Mr. Stiles, thank you for joining us today. T.J. Stiles: Thanks very much for interviewing me...
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Novel Approaches for the Application of Mitochondrial Respirometry in Human Studies
No full textThough mitochondrial research has become more prominent in the last forty years, most methodologies to study mitochondria have been focused on cell and animal models. Respirometry, the assessment of mitochondrial function measured as oxygen consumption by Complex IV of the electron transport chain, is the “gold standard” for mitochondrial assessment, yet it is rarely utilized in human samples. This is due to two fundamental methodological challenges: (1) samples for respirometry must be processed and ran within hours of acquisition on specialized and complex equipment, and (2) human sampling for respirometry must be acquired using invasive tissue biopsies. While we as a field realize the importance of oxygen consumption as a measurement of mitochondrial function, the current methodologies are now limiting the types of biological and clinical questions we can ask and answer. Addressing the first challenge preventing widespread adoption of respirometry, the recently developed RIFS (Respirometry In previously-Frozen Specimen) assay allows for the measurement of maximal respiratory capacity from cells or tissues which have been previously frozen. This allows samples to be processed and then stored or biobanked for later respirometry assessment, ultimately making respirometry methodologies significantly easier, cheaper, and more accessible. To the second challenge though, there has been minimal breakthrough.In this thesis we will cover novel methodologies overcoming challenges which are paramount to the expansion of respirometry methodologies for clinical applications. We will discuss the RIFS protocol in detail, describe the methodologies developed to perform a first-of-its-kind high-throughput and high-resolution respirometry study of the human brain, and will detail the development of a technique to measure mitochondrial respiration in cells human salivary leukocytes. Together, these chapters present novel methodologies designed to overcome the primary limitations of performing respirometry in human studies
Characterization of a bacteriocin with effectivity against Klebsiella
No full textWithin the last century, antibiotics have been discovered and proved to be successful in killing or inhibiting growth of bacteria. However, in its short history, antibiotics have been overprescribed and misused, which has caused many species of bacteria to become resistant to its effects. This has led to a dramatic increase in infections that cannot be resolved with antibiotics. Therefore, antimicrobial research has turned to finding new ways to counter bacterial infections such as understanding and utilizing polymicrobial interactions. Previous research in our laboratory has found that Klebsiella pneumoniae, a Gram-negative, rod-shaped bacterium that can cause pneumonia, possess inhibitory properties that reduce the growth of certain bacterial genus including Enterobacter, Citrobacter, and even other Klebsiella species. In the current research, our lab has demonstrated that supernatant from a specific strain of K. pneumoniae, which includes the bacteria’s metabolites and proteins without cells, have antimicrobial properties that inhibit growth of other strains of K. pneumoniae including K. Pneumoniae 9997 in both planktonic and biofilm growth. Development of a treatment that delivers the antimicrobial compound from K. pneumoniae to those with drug resistant infections could become an alternative treatment to antibiotics that have failed in treating infections
The relationships among mental ability, academic achievement and vocational interests of a randomly selected group of students in the Sol C. Johnson High School, 1961
No full textProgress Report on a Survey of the Spiders of Iowa
No full textThe senior author began a study of Iowa spiders in the fall of 1936 when a black widow (Latrodectus mactaus texanus) was collected in Linn County. This was reported in Science (Stiles, 1937) and constituted the first official record of the black widow for Iowa. This record was of special interest because Minnesota and Iowa had been listed as the only states from which this spider had not been reported officially. It was discovered at that time that the spider was one of Iowa\u27s most neglected animals. Only three papers on our spider fauna have been reported to the Iowa Academy of Science in the past fifty years ; and there are no good collections of spiders in the State at the present time. In view of the incompleteness of our knowledge concerning Iowa\u27s spiders, it was thought worthwhile to begin a systematic study of them. It is the ambition of the Coe College Biology Department to make a study of the Araneae similar to that which Jaques (1932) is making on insects, thereby rounding out, somewhat, our knowledge of Iowa animal life. This is being undertaken with a full realization of the tremendous size of the task and the improbability that it will ever be wholly finished
A study of the enuretic children attending a day nursery and a nursery school in Atlanta, Georgia from February 1946 to March 1947, 1947
No full textKetchup and Blood: Documents, Institutions and Effects in the Performances of Paul McCarthy 1974-2013
No full textSince the 1970s, the work of Los Angeles-based artist Paul McCarthy (b. 1945) has included live performance, video, sculpture, kinetic tableaux, and installation. Tracing the development of McCarthy’s work between 1974 and 2013, I undertake a critical discussion of the development of performance in relation to visual art practices. Using one artist’s work as a guide through a number of key discussions in the history of performance art, I argue that performance has influenced every aspect of McCarthy’s artistic practice, and continues to inform critical readings of his work.
My thesis follows the trajectory of McCarthy’s performance practice as it has developed through different contexts. I begin with the early documentation and dissemination of performance in the Los Angeles-based magazine High Performance (1978-83), which established a context for the reception of performance art, and for McCarthy’s early work. I then examine specific examples of McCarthy’s practice in relation to his critical reception: live performances and videos from the 1970s are discussed alongside critical readings of his work influenced by psychoanalysis; and the wider public recognition of McCarthy’s object-based art in the 1980s and early 1990s. I then look more broadly at the recent trend of re-enacting historical performances in the Getty’s Pacific Standard Time project (2011-12), as a mode of engaging with performance history and exploring how histories of ephemeral art are re-iterated over time. Finally, I discuss a number of McCarthy’s recent exhibitions and installations that mobilises a wider consideration of the histories of performance and ephemeral practices in art institutions.
McCarthy’s work is firmly established in the art world, and I argue that his work also provides a significant touchstone for histories of performance. I look historically at how McCarthy’s work has been documented, disseminated, curated, and re-performed, and open wider discussions about ways of engaging with performance history. In turn, I complicate the relationship between performance and the art world; between ephemeral art and object-based art practices; and between scholarly engagements with performance history, and the public presentation of performance in curatorial practices and institutional contexts.This project was funded by a College Studentship from Queen Mary, University of London. Additional financial support for a research trip to Los Angeles in 2012 to undertake primary research and conduct interviews was provided by the Queen Mary Central Research Fund (now the Postgraduate Research Fund). I would also like to acknowledge the support of the Glynne Wickham Scholarship fund, which contributed to travel expenses for a conference presentation at Stanford University in 2013
Employing a Case Study in Building an Assimilation Theory Account of Generalized Anxiety Disorder and Its Treatment with Cognitive-Behavioral Therapy
No full textThis theory-building case study aimed to elaborate an account of anxiety and its treatment within an assimilation model of therapeutic change (e.g., Stiles, 2002). A team consisting of the senior author and two other co-investigators independently reviewed the case of Robert, a 52 year-old man who was successfully treated for generalized anxiety disorder (GAD) in a clinical trial of cognitive behavior therapy (CBT). The team observed the expression of Robert's major voices—the assimilation model’s name for the individual parts of a client’s personality—in the audio record of the client’s in-session dialogue. Prominent among these was a critic voice, described by co-investigators as harsh and derisive toward other aspects of the self. Our work led us to infer that, although the critic voice seemed closely associated with the anxiety that characterized Robert's GAD, it did not produce that anxiety directly through its attacks on his other voices. Rather, the critic voice induced vulnerability to specific, anxiety-arousing external circumstances by derogating Robert's coping skills or exaggerating the threat of specific external circumstances. Robert's anxiety then arose when he encountered those circumstances.
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