13,208 research outputs found
Electrochemical reduction of NO2 at a Pt/membrane electrode-Application to amperometric NO2 sensing
No full textVascular endothelial growth factor restores delayed tumor progression in tumors depleted of macrophages
No full textGenetic depletion of macrophages in Polyoma Middle T oncoprotein (PyMT)-induced mammary tumors in mice delayed the angiogenic switch and the progression to malignancy. To determine whether vascular endothelial growth factor A (VEGF-A) produced by tumor-associated macrophages regulated the onset of the angiogenic switch, a genetic approach was used to restore expression of VEGF-A into tumors at the benign stages. This stimulated formation of a high-density vessel network and in macrophage-depleted mice, was followed by accelerated tumor progression. The expression of VEGF-A led to a massive infiltration into the tumor of leukocytes that were mostly macrophages. This study suggests that macrophage-produced VEGF regulates malignant progression through stimulating tumor angiogenesis, leukocytic infiltration and tumor cell invasion
Cardiac rupture after minor blunt chest injury as a result of occult recent myocardial infarction.
No full textLysophospholipids Enhance Matrix Metalloproteinase-2 Expression in Human Endothelial Cells
No full textHigh-performance carbon-based supercapacitors using Al current-collector with conformal carbon coating
No full textDenaturing HPLC coupled with multiplex PCR for rapid detection of large deletions in Duchenne muscular dystrophy carriers
No full textDenaturing HPLC Coupled with PCR for Rapid Detection of Large Deletions in Duchenne Muscular Dystrophy Carriers. Clin Chem
No full textLIN-41 does not function as an E3 ubiquitin ligase.
No full text<p><b>A.</b> Sequence alignment of the mammalian TRIM71/LIN-41 RING domain with those from <i>Caenorhabditis</i> species and different known E3 ubiquitin ligases. Asterisks indicate the position of conserved cysteines (<i>C. elegans</i>: C114, C117, C130, C151, C154), which have been mutated to serines (S) to disrupt the domain (LIN-41<sup>RING</sup>). A highly conserved proline residue (P, highlighted in yellow), which is critical for canonical E3-E2 interactions, is absent in the nematode LIN-41 proteins. <b>B.</b> Fluorescent micrographs of live animals expressing wild-type (LIN-41<sup>WT</sup>) and mutated (LIN-41<sup>RING</sup>) GFP-tagged LIN-41 in the <i>lin-41(rrr3)</i> mutant background. The gonads are outlined with a dashed line. No differences in the distribution or in the levels of the two proteins have been observed (n>50). Scale bar: 20 µm.</p
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