95,966 research outputs found
Probing and extracting the structure of vibrating SF6 molecules with inner-shell photoelectrons
No full textCitation: Nguyen, N. T., Lucchese, R. R., Lin, C. D., & Le, A. T. (2016). Probing and extracting the structure of vibrating SF6 molecules with inner-shell photoelectrons. Physical Review A, 93(6), 9. doi:10.1103/PhysRevA.93.063419We propose a scheme for probing the structure of vibrating molecules with photoelectrons generated from ultrashort soft-x-ray pulses. As an example we analyze below-100-eV photoelectrons liberated from the S(2p) orbital of vibrating SF6 molecules to image very small structural changes of molecular vibration. In particular, photoionization cross sections and photoelectron angular distributions (PAD) at nonequilibrium geometries can be retrieved accurately with photoelectrons near the shape resonance at 13 eV. This is achieved with a pump-probe scheme, in which the symmetric stretch mode is first Raman excited predominantly by a relatively short laser pulse and then later probed at different time delays by a few-femtosecond soft-x-ray pulse with photon energy near 200 eV
Cleruchoides Lin & Huber 2007
No full textCleruchoides Lin & Huber, 2007. Not illustrated.Published as part of Huber, John T., Bolte, Klaus & Read, Jennifer D., 2023, The morphological diversity of Mymaridae (Hymenoptera): an atlas of scanning electron micrographs. Part 1. General overview and structure of the head, pp. 1-100 in Zootaxa 5273 (1) on page 26, DOI: 10.11646/zootaxa.5273.1.1, http://zenodo.org/record/789251
LIN-1 sumoylation is required for ventral toroid contraction.
No full text(A) Wild-type and K10A, K169A mutant LIN-1::GFP expression in L3 larvae at the Pn.px stage after VPC-specific degradation of AID::SMO-1 from the L2 stage onward. The 1° and 2° VPC descendants are underlined in white. The left panels show the corresponding DIC images overlaid with the LIN-1::GFP signal in green. (B) Quantification of LIN-1::GFP expression levels in 1° and 2° VPC descendants at the Pn.px stage in LIN-1::GFP wild-type and K10A, K169A double mutants under the indicated conditions. See S3 Fig for the corresponding measurements at the Pn.pxx stage. (C) Toroid morphogenesis defects in LIN-1 K10A and K169A single and double mutants at the L4 stage. Left panels show lateral views of z-projections. vulA and vulB1 toroids are outlined by the white rectangle in the top left panel and shown in top (xz) views in the right panels. (D) Quantification of vulA contraction, calculated as the ratio of the vulA and vulB1 toroid diameter. The box plots show the median values with the 25th and 75th percentiles and the whiskers indicate the maximum and minimum values. Where indicated, untreated controls are labelled with–IAA (blue) and animals treated with 1 mM auxin with +IAA (red). In each graph, the numbers of animals scored are indicated by the numbers in brackets. Statistical significance in (B) and (D) was calculated with unpaired two-tailed t-tests. p-values are indicated as * p ≤ 0.05; ** p ≤ 0.01; *** p ≤ 0.001. The scale bars are 10 μm.</p
Parastethynium Lin & Huber 2011
No full textParastethynium Lin & Huber, 2011. Papua New Guinea, West New Britain, Dami Oil Palm Research Station. Figs A56, B52, C57, D58, E52, F54a,b (all P. maxwelli (Girault)).Published as part of Huber, John T., Bolte, Klaus & Read, Jennifer D., 2023, The morphological diversity of Mymaridae (Hymenoptera): an atlas of scanning electron micrographs. Part 1. General overview and structure of the head, pp. 1-100 in Zootaxa 5273 (1) on page 28, DOI: 10.11646/zootaxa.5273.1.1, http://zenodo.org/record/789251
Retrieval of target structure information from laser-induced photoelectrons by few-cycle bicircular laser fields
No full textCitation: Hoang, V. H., Le, V. H., Lin, C. D., & Le, A. T. (2017). Retrieval of target structure information from laser-induced photoelectrons by few-cycle bicircular laser fields. Physical Review A, 95(3), 6. doi:10.1103/PhysRevA.95.031402By analyzing theoretical results from a numerical solution of the time-dependent Schrodinger equation for atoms in few-cycle bicircular laser pulses, we show that high-energy photoelectron momentum spectra can be used to extract accurate elastic scattering differential cross sections of the target ion with free electrons. We find that the retrieval range for a scattering angle with bicircular pulses is wider than with linearly polarized pulses, although the retrieval method has to be modified to account for different returning directions of the electron in the continuum. This result can be used to extend the range of applicability of ultrafast imaging techniques such as laser-induced electron diffraction and for the accurate characterization of laser pulses
Vascular endothelial growth factor restores delayed tumor progression in tumors depleted of macrophages
No full textGenetic depletion of macrophages in Polyoma Middle T oncoprotein (PyMT)-induced mammary tumors in mice delayed the angiogenic switch and the progression to malignancy. To determine whether vascular endothelial growth factor A (VEGF-A) produced by tumor-associated macrophages regulated the onset of the angiogenic switch, a genetic approach was used to restore expression of VEGF-A into tumors at the benign stages. This stimulated formation of a high-density vessel network and in macrophage-depleted mice, was followed by accelerated tumor progression. The expression of VEGF-A led to a massive infiltration into the tumor of leukocytes that were mostly macrophages. This study suggests that macrophage-produced VEGF regulates malignant progression through stimulating tumor angiogenesis, leukocytic infiltration and tumor cell invasion
Kompsomymar Lin & Huber 2007
No full text<p> <i>Kompsomymar</i> Lin & Huber, 2007.</p> <p>Not illustrated.</p>Published as part of <i>Huber, John T., Bolte, Klaus & Read, Jennifer D., 2023, The morphological diversity of Mymaridae (Hymenoptera): an atlas of scanning electron micrographs. Part 1. General overview and structure of the head, pp. 1-100 in Zootaxa 5273 (1)</i> on page 27, DOI: 10.11646/zootaxa.5273.1.1, <a href="http://zenodo.org/record/7892514">http://zenodo.org/record/7892514</a>
D. T. Max, 36th Annual ODU Literary Festival
No full textD. T. Max is a graduate of Harvard University and a staff writer at The New Yorker. His new book, Every Love Story Is A Ghost Story: A Life of David Foster Wallace, was released in August 2012 and was a New York Times best-seller. He is also the author of The Family That Couldn\u27t Sleep: A Medical Mystery
Tim-1 signaling and localization during T cell activation
No full textTransmembrane immunoglobulin and mucin 1 (Tim-1) belongs to a family of cell surface proteins with roles in immune regulation, among other functions. Tim-1 polymorphisms have been implicated in human asthma susceptibility, and antibody modulation of Tim-1 has been shown to modulate murine models of autoimmune disease and allograft tolerance. This ability of Tim-1 to influence disease progression has been attributed to its role in co-stimulating T cell function, inducing transcriptional activation, and skewing cytokine production.
Despite the emerging role of Tim-1 in immune modulation, the molecular mechanisms underlying Tim-1 function remain largely unidentified. We and others have demonstrated that Tim-1 is a co-stimulatory molecule with the ability to enhance transcriptional activation. However, it is unknown where Tim-1 localizes upon T cell activation, an avenue of investigation that has yielded important insights about other molecules involved in T cell activation. Using imaging, I demonstrate that in contrast to most co-stimulatory molecules, murine Tim-1 localizes away from the immunological synapse, and towards the distal pole complex in manner dependent on ezrin/radixin/moesin (ERM) family proteins. This localization is important for Tim-1 enhancement of cytokine production. In addition, a variety of molecular, pharmacological, and biochemical methods were used to examine the molecules and pathways induced downstream of Tim-1 activation. In particular, I discovered that Tim-1 can trigger NFAT/AP-1 activation in a PLC-1 independent, but TCR- and CD28-dependent, manner.
Overall, this dissertation reveals some of the complexity underlying Tim-1 function. Better understanding of where and how Tim-1 interacts with other molecules will provide greater insight into Tim-1 mediated T cell activation and disease modulation
Camptopteroides (Alalinda) dorothea Huber in Huber & Lin 1999
No full textCamptopteroides (Alalinda) dorothea Huber, 1999 Camptopteroides (Alalinda) dorothea Huber in Huber & Lin, 1999: 35. Holotype ♀ (CNC). TL: USA, South Carolina, Anderson Co., Pendleton. Distribution. USA: FL, MO, SC, VA.Published as part of Huber, John T., Read, Jennifer D. & Triapitsyn, Serguei V., 2020, Illustrated key to genera and catalogue of Mymaridae (Hymenoptera) in America north of Mexico, pp. 1-411 in Zootaxa 4773 (3) on page 103, DOI: 10.11646/zootaxa.4773.1.1, http://zenodo.org/record/382137
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