168 research outputs found
Aerodynamic optimization of an adaptive flap for next-generation green aircraft
Get PDFAdaptive, morphing flaps are taking ever-increasing attention in civil aviation thanks to the expected benefits this technology can bring at the aircraft level in terms of high-lift performance improvement and related fuel burnt reduction per flight. Relying upon morphing capabilities, it is possible to fix a unique setting for the flap and adapt the flap shape to match the aerodynamic requirements for take-off or landing. The proper morphed shapes can assure better high-lift performances than those achievable by referring to a conventional flap. Moreover, standing the unique flap setting for take-off and landing, a dramatic simplification of the flap deployment systems may be achieved. As a consequence of this simplification, the deployment system can be fully hosted in the wing, thus avoiding under-wing nacelles with significantly better aerodynamics and fuel consumption. The first step for a rational design of an adaptive flap consists in defining the target morphed shapes and the unique optimal flap setting in the take-off and landing phases. In this work, aerodynamic optimization analyses are carried out to determine the best flap setting and related morphed shapes in compliance with the take-off and landing requirements of a reference civil transport aircraft. Four different initial conditions are adopted to avoid the optimization falling into local optima, thus obtaining four groups of optimal candidate configurations. After comparing each candidate's performance through 2D and 3D simulations, the optimal configuration has been selected. 2D simulations show that the optimal configuration is characterized by a maximum lift increase of 31.92% in take-off and 9.04% in landing. According to 3D simulations, the rise in maximum lift equals 22.26% in take-off and 3.50% in landing. Numerical results are finally verified through wind tunnel tests, and the aerodynamic mechanism behind the obtained improvements is explained by carefully analyzing the flow field around the flap
RETRACTED ARTICLE: Lycium barbarum polysaccharide alleviates oxygen glucose deprivation-induced PC-12 cells damage by up-regulating miR-24
No full textWe, the Editors and Publisher of the journal Artificial Cells, Nanomedicine, and Biotechnology, have retracted the following article:Shiqing Song, Faliang Lin, Pengyan Zhu, Changyan Wu, Shuling Zhao, Qiao Han & Xiaomei Li (2019) Lycium barbarum polysaccharide alleviates oxygen glucose deprivation-induced PC-12 cells damage by up-regulating miR-24. Artificial Cells, Nanomedicine, and Biotechnology, 47(1), 3994–4000, DOI: 10.1080/21691401.2019.1673767Since publication, concerns have been raised about the integrity of the data in the article. When approached for an explanation, the authors have been unable to verify their original data. We also have concerns regarding the integrity of the authorship, as one author has stated they did not consent to being listed as an author. We are therefore retracting this article and the corresponding author listed in this publication have been informed.We have been informed in our decision-making by our policy on publishing ethics and integrity and the COPE guidelines on retractions.The retracted article will remain online to maintain the scholarly record, but it will be digitally watermarked on each page as ‘Retracted’
Anufrievia akazu
No full text2. Anufrievia akazu (Matsumura, 1932) n. rec. for China (Fig. 25b) Zygina akazu Matsumura, 1932: 108 Anufrievia akazu: Dworakowska 1970: 763, Fig. 18; Ohara, 2013: 244, Figs 1–2, 8–16 Anufrievia vilbastei Dworakowska, 1970: 763, Figs 12–17. syn. Material examined: 1♂ [NWAFU], CHINA: Sichuan Prov., Mt. Qingcheng, 14.ix.1988, coll. Zhou Jingruo, Zheng Shuling & Xu Qiuyuan. Distribution: China (Sichuan); Japan; Korea.Published as part of Cao, Yanghui, Yang, Meixia, Lin, Shuanghu & Zhang, Yalin, 2018, Review of the leafhopper genus Anufrievia Dworakowska (Hemiptera: Cicadellidae: Typhlocybinae: Erythroneurini), pp. 203-232 in Zootaxa 4446 (2) on page 205, DOI: 10.11646/zootaxa.4446.2.2, http://zenodo.org/record/144409
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Nonparametric regression analysis
Get PDFtextNonparametric regression uses nonparametric and flexible methods in analyzing complex data with unknown regression relationships by imposing minimum assumptions on the regression function. The theory and applications of nonparametric regression methods with an emphasis on kernel regression, smoothing spines and Gaussian process regression are reviewed in this report. Two datasets are analyzed to demonstrate and compare the three nonparametric regression models in R.Statistic
OVERCOMING THE LIMITS TO GLOBALISATION: A PRODUCT MODULARITY PERSPECTIVE
No full textBachelor'sBACHELOR OF BUSINESS ADMINISTRATION WITH HONOUR
Sphingosine-1-phosphate/S1P Receptors Signaling Modulates Cell Migration in Human Bone Marrow-Derived Mesenchymal Stem Cells
No full textThe recruitment of bone marrow-derived mesenchymal stem cells (BMSCs) to damaged tissues and sites of inflammation is an essential step for clinical therapy. However, the signals regulating the motility of these cells are still not fully understood. Sphingosine-1-phosphate (S1P), a bioactive sphingolipid metabolite, is known to have a variety of biological effects on various cells. Here, we investigated the roles of S1P and S1P receptors (S1PRs) in migration of human BMSCs. We found that S1P exerted a powerful migratory action on human BMSCs. Moreover, by employing RNA interference technology and pharmacological tools, we demonstrated that S1PR1 and S1PR3 are responsible for S1P-induced migration of human BMSCs. In contrast, S1PR2 mediates the inhibition of migration. Additionally, we explored the downstream signaling pathway of the S1P/S1PRs axis and found that activation of S1PR1 or S1PR3 increased migration of human BMSCs through a G(i)/extracellular regulated protein kinases 1/2-(ERK1/2-) dependent pathway, whereas activation of S1PR2 decreased migration through the Rho/Rho-associated protein kinase (ROCK) pathway. In conclusion, we reveal that the S1P/S1PRs signaling axis regulates the migration of human BMSCs via a dualdirectional mechanism. Thus, selective modulation of S1PR's activity on human BMSCs may provide an effective approach to immunotherapy or tissue regeneration.Cell BiologyImmunologySCI(E)[email protected]
Poly(glycerol sebacate)/Bioglass® elastomeric biocomposites for tissue engineering
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Enhancement of Carbon Nanotube Particle Distribution in PPS/PEEK/Carbon Nanotube Ternary Composites with Sausage-Like Structure
No full textCarbon nanomaterial particles were selectively distributed in an incompatible and high-melting-temperature polymer blend interface, or in a particular phase, to obtain conductive composites. The composite products revealed poor morphology stability and mechanical performance due to processing several times. Poly(phenylene sulfide) (PPS) and poly(ether ether ketone) (PEEK) polymers with large differences of processing temperatures were selected as blend components to obtain a compatible blend. PPS/PEEK/multi-walled carbon nanotube (MWCNT) ternary nanocomposites were prepared using a controlled melt blending process. The composite samples with similar sausage-like structures of PEEK, as a dispersed phase, promote MWCNT to maximize concentration distribution in the PPS continuous phase. As a result, the theoretical percolation threshold of the composite reduced to 0.347 wt %. Moreover, the conductivity of the composite remained stable even after processing several times. CNTs revealed a particular effect when distributed selectively in this kind of system: it can enhance the dispersion of phases and also provide conductivity to the blend at small CNT contents, which can provide more useful ideas for the development of high-melting-temperature and antistatic or conductive plastic materials
miR-300 rs12894467 polymorphism may be associated with susceptibility to primary lung cancer in the Chinese Han population
No full textZhiqiang Liu,1,2 Yong Lin,3 Shuling Kang,4 Qiuping Xu,2 Weimin Xiong,2 Lin Cai,2 Fei He2,5 1The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, Fujian, China; 2Department of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou, Fujian, China; 3Clinical Laboratory, Zhongshan Hospital, Medical College of Xiamen University, Xiamen, Fujian, China; 4Fuzhou Center for Disease Control and Prevention, Fuzhou, Fujian, China; 5Key Laboratory of Ministry of Education for Gastrointestinal Cancer, Fujian Medical University, Fuzhou, Fujian, China Objective: The etiology of lung cancer has been attributed to both environmental and genetic factors. In this study, we investigated the association between five miRNA gene single-nucleotide polymorphisms (SNPs) and the risk of lung cancer, and explored the interaction between genetic and environmental factors in the Han people of China, the ethnic group that represents >90% of the population of the country.Methods: This case–control study included 1,067 cases and 1,085 controls. Epidemiological data were collected by in-person interviews using a standard questionnaire. Matrix-assisted laser desorption/ionization time of flight mass spectrometry was applied to genotype the selected miRNA gene SNPs. Unconditional logistic regression and stratified analysis were used to analyze the associations between these SNPs and lung cancer, and to calculate the adjusted odds ratios (ORs) and 95% confidence intervals (CIs). Crossover analysis, logistic regression, and the Excel table made by Andersson were used to analyze the combined and interaction effects of gene–environment.Results: The rs12894467 CC/CT genotype was associated with a significantly increased risk for lung cancer in women (adjusted OR =1.46, 95% CI=1.01–2.10). Smokers carrying the CC/CT genotype were associated with a significantly decreased risk of lung cancer, the adjusted OR was 0.75 (95% CI: 0.57–0.98). In the dominant model, rs12894467 and gender were associated with a positive multiplicative interaction; rs12894467 and smoking were associated with a negative multiplicative interaction.Conclusion: The rs12894467 polymorphism was potentially associated with primary lung cancer in the Han Chinese population and had an interactive relationship with environmental factors. Keywords: microRNAs, single-nucleotide polymorphism, lung cancer, case–control studies, susceptibilit
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