208,661 research outputs found
The effect of BisGMA on cyclooxygenase-2 expression, PGE2 production and cytotoxicity via reactive oxygen species- and MEK/ERK-dependent and -independent pathways
No full textCopyright © 2009 Elsevier Ltd All rights reserved.Mei-Chi Chang, Li-Deh Lin, Chiu-Po Chan, Hsiao-Hua Chang, Lin-I. Chen, Hsueh-Jen Lin, Hung-Wei Yeh, Wan-Yu Tseng, Po-Shuen Lin, Chiu-Chun Lin and Jiiang-Huei Jenghttp://www.elsevier.com/wps/find/journaldescription.cws_home/30392/description#descriptio
Is UNESCO Recognition Effective in Fostering Tourism? A Comment on Yang, Lin and Han: Reply
No full textCome tradurre Milo De Angelis
No full textThe section presents the Chinese translation of four poems by Milo De Angelis, who is
among the best Italian contemporary poets. The poems are taken from the collection "Incontri e agguati" (Mondadori, 201 5). The texts are both in Italian and Chinese in parallel
text. Yang Lin, with the help of Geng Jiang (Chinese musician and poet), took care of the
translation.
The section opens with a note made by the translation group that analyses the processes
of the transposition of the dense poetic language of De Angelis into the Chinese language.
There follows an enlightening letter from Milo De Angelis to the translation group. The four
poems in Chinese and Italian complete the section
The stem cell E3-ligase Lin-41 promotes liver cancer progression through inhibition of microRNA-mediated gene silencing
No full textLin-41 is a stem cell-specific E3 ligase and a known target of the tumour suppressor microRNA (miRNA) let-7. Lin-41 was recently reported to mediate ubiquitylation and degradation of the miRNA pathway protein Ago2. We demonstrate that Lin-41 is over-expressed in hepatocellular carcinoma (HCC). Lin-41 over-expression correlates with high a-fetoprotein level, high tumour grade and high tumour stage and predicts early tumour recurrence. Lin-41 is a strong predictor of poor long-term survival for patients with HCC. Lin-41 knock-down by RNA interference in HCC cell lines Huh7 and Hep3B suppressed proliferation in vitro and reduced in vivo tumour growth in NOD/SCID mice. On the other hand, over-expression of Lin-41 in the HCC cell line SK-Hep1 enhanced tumourigenicity. Over-expression and knock-down of Lin-41 led to inverse changes in the levels of Ago1 and Ago2 proteins. Over-expression of Ago1 and Ago2 reduced in vivo tumour growth. Lin-41 over-expression suppressed let-7 activity in HCC cell lines and expression of Lin-41 enhanced the expression of let-7-regulated oncogenes c-Myc, Lin-28B, HMGA2 and type 1 insulin-like growth factor receptor (IGF1R). Expression of Lin-28B and c-Myc enhanced the expression of Lin-41. Chromatin immunoprecipitation and reporter assays revealed direct association of c-Myc with the Lin-41 promoter, resulting in transcriptional transactivation. Our results indicate that Lin-41 plays an important role in the growth of HCC by regulating RISC complex proteins Ago1 and Ago2 to inhibit miRNA-mediated gene silencing and promote the expression of oncogenic proteins. Lin-41 is also a strong prognostic factor for patients with HCC. Copyright (C) 2012 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd
Eutetrapha weni Huang & Lin 2016
No full textEutetrapha weni Huang & Lin, 2016 Figs. 63–65 Eutetrapha weni Huang & Lin, 2016: 590, figs. 1–23. Diagnosis. This species can be separated from congeners by the unique brick red brown pubescence and unique elytral markings, larger body size, and unique golden brown metatarsi. Remarks. For descriptions, see paper by Huang & Lin (2016). The description of male genitalia was in older style (Huang & Lin 2 016) and some terminology terms are changed in this work: median lobe plus median struts = median lobe; internal sac = endophallus; basal armature = basal plate-like sclerites; rods of endophallus = rod-like sclerites. Distribution. China: Guizhou. Material examined. Holotype, male (Fig. 62, and Figs. 1 a & 1b in Huang & Lin 2016), China, Guizhou, Leishan, Mt. Leigongshan, Lianhuaping, N26°22′, E108°12′, alt. 1631 m, 2014. VI.18, leg. Jing Yang (IZAS, IOZ (E) 1905306, ex KLUC). Paratypes: 1 female, same data to holotype but deposited in (KLUC); 1 female, same data to holotype but 2014. VI.16 and deposited in (KLUC); 1 male (Fig. 13 in Huang & Lin 2016) 1 female (Figs. 8 a, 8b & 14 in Huang & Lin 2016), same data to holotype but 2014. VI.21, leg. Yang Li (IZAS, IOZ (E) 1905304–05, ex KLUC); 1 female (Fig. 65), same data to holotype but, 2011. VIII.11, leg. Jian-Yue Qiu & Hao Xu (CWD); 1 female, same data to holotype, but 2015. VII.12, leg. Bo-Yan Li (CGQH); 1 male (Fig. 64), S. China, SE. Guizhou, Dushan County, Gengdingshan env., N25°52.5′, E107°38′, alt. 1445 m, 2009.VI, leg. Sehnal et Hackel (CPV).Published as part of Lin, Mei-Ying, Bi, Wen-Xuan & Yang, Xing-Ke, 2017, A revision of the genus Eutetrapha Bates (Coleoptera: Cerambycidae: Lamiinae: Saperdini), pp. 151-202 in Zootaxa 4238 (2) on pages 172-173, DOI: 10.11646/zootaxa.4238.2.1, http://zenodo.org/record/34519
A stiffness matrix approach for the design of statically balanced planar articulated manipulators
No full text
Parastenostola nigroantennata Lin et Yang, sp. nov.
No full textParastenostola nigroantennata Lin et Yang, sp. nov. (Figs. 24–29) Description. Male: length: 14.0– 14.5 mm, humeral width: 4.0– 4.3 mm. Female: length: 14.0– 17.8 mm, humeral width: 4.0– 5.2 mm. Body black; frons densely closed with yellow pubescence, eyes circled with yellow pubescence, occiput black; antennae pitchy with thick gray pubescence; pronotum with a moderate black macula not reaching basal margin on disc, with yellow pubescence at sides except for a small black spot on middle of each side; scutellum and elytra black with dense gray short pubescence, giving a black-gray appearance; ventral surface clothed with yellow pubescence at sides and with gray pubescence along middle of venter; pubescence on mesepisternum not so thick, gray, sometimes mixed with yellow. Head fine and unevenly punctured. Lower eyelobes much longer (male) or slightly longer (male) than genae. Antennae not stout, longer (male) or slightly shorter (female) than body length; antennomere ratio: male: 16 4 25 21 16 15 14 13 12 11 13; female: 14 3 21 19 16 12 11 10 9 9 10. Punctures on pronotum irregular and uneven. Scutellum linguaform. Elytra evenly narrowed posteriorly, rounded or slightly truncated apically, densely punctured, punctures smaller than their interspaces. Legs moderately stout, middle tibiae with lots of hairs externally, hind femur reaching middle to apex of third abdominal segment. Male genitalia (Fig. 27): Tegmen about 3.4 mm; lateral lobes short, each about 0.5 mm long and 0.12 mm wide, with setae at the apex and around of dorsal surface, with two small lobes furnished with short and fine hairs at the ventral base; roof very short; ringed part elbowed in the widest portion, converging; basal piece slightly bifurcated distally; median lobe with median struts slightly curved, a little longer than tegmen (20: 17); the former distinctly shorter than the latter, less than 1 / 2 of median struts; dorsal plate subequal to ventral plate; the ventral edge of median orifice weakly projected; median foramen extremely elongated; internal sac moderately long, with four long and thin rods and a small crescent armature at the basal of rods, the hair-like rods about 5.0 mm, much longer than tegmen or median lobes. Ejaculatory duct single. Female genitalia (Figs. 28–29): Setae of sternite 7–8 long, extending beyond apex. Spermatheca distinctly curved, dividing into 5–8 different parts, about 2.2 mm long for a 17 mm adult. Tignum short, shorter than 1 / 3 of abdomen. The tignum 1.9 mm for an adult with a 7.0 mm abdomen in ventral view. Diagnosis. Differs from P. brunnips (Gahan) in the black antennae, femera and tibiae. Etymology. This species differs from P. brunnips (Gahan) by the black antennae. Type specimens examined. Holotype: male, Guangxi, Tianlin county, Langping Xiang, 1200–1400 m, 2002. V. 29, coll. Jianwen Liu (IZAS). Paratypes: 1 male, Guangxi, Tianlin county, Jiudongping, 1200–1300 m, 2002. V. 27, coll. Xiujuan Yang (HBU); 1 female, Guangxi, Tianlin county, Yaojiawan, 1200–1400 m, 2002. VI. 3, coll. Xiujuan Yang (HBU); 1 male 1 female, Guangxi, Wuming county, 2005. VI. 20–30, coll. Chenghui Zhan (IZAS); 1 female, Guangxi, NNW 100 k of Nanning, Mt. Damingshan, 2005.VI (CWIC); 1 female, Guizhou, Guiyang Forest Park, 2007. V. 9, leg. Meng Yuan & Long Zhang (IZAS). Distribution. China: Guangxi, Guizhou.Published as part of Lin, Meiying, Li, Wenzhu & Yang, Xingke, 2008, Taxonomic review of three saperdine genera, Mandibularia Pic, Mimocagosima Breuning and Parastenostola Breuning (Coleoptera: Cerambycidae: Lamiinae: Saperdini), pp. 1-17 in Zootaxa 1773 on pages 12-13, DOI: 10.5281/zenodo.27427
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