50 research outputs found
Research of inflation rate and its determinants: An analysis of GSK corporation in United States
No full textWith the rapid development of technology and the economy, more and more companies realized that the macroeconomic factors are quite important in terms of the big changes of them might carry the systematic risks to the whole system. For example, the subprime crisis happened in the United States in 2007 and eventually caused the financial crisis to the whole world. Therefore, this paper will choose the GSK corporation as the sample and analyze the inflation risk and the determinants of it. During this paper, the author used the inflation rate as dependent variables and ROA, ROE, corporate governance index, Tobin’s Q, Altman-Z score, GDP growth rate and the unemployment rate as the independent variables in order to find the relationship among these variables
Development And Application Of Product Tracebility A System：An Empirical Study Of A Domestic Biotechnology Company
No full text目錄
中文摘要 I
ABSTRACT II
謝誌 V
第一章 緒論 - 1 -
1-1 研究背景與動機 - 1 -
1-2 研究目的 - 3 -
1-3 研究流程 - 4 -
第二章 文獻探討 - 6 -
2-1 資訊系統開發流程 - 6 -
2-2 生產履歷的作業程序 - 7 -
2-3 國際藥廠稽查公約組織標準 - 8 -
2-4 本體論 - 11 -
2-5 生產履歷系統應用成效評估指標 - 14 -
2-6 層級分析法 - 16 -
第三章 研究設計 - 22 -
3-1 研究架構 - 22 -
3-2 生產履歷系統之建立 - 24 -
3-3 建立生產履歷系統應用成效指標 - 26 -
3-4 個案研究法 - 31 -
第四章 結果與討論 - 32 -
4-1 實證分析 - 32 -
4-1-1 個案背景說明 - 32 -
4-1-2 問卷資料分析 - 33 -
4-2 系統實作與範例展示 - 48 -
4-2-1 系統開發過程 - 48 -
4-2-2 系統實作環境與開發工具 - 48 -
4-2-3 系統架構 - 49 -
4-2-4 系統功能 - 50 -
4-2-5 畫面展示 - 54 -
4-2-6 個案公司訪談資料 - 59 -
4-3 生產履歷系統之效益分析 - 60 -
4-4 導入系統預期問題及建議措施 - 60 -
第五章 結論 - 62 -
5-1 結論 - 62 -
5-2 研究貢獻 - 62 -
5-3 研究限制 - 63 -
5-4 後續研究建議 - 64 -
文獻參考 - 65 -
附錄 - 68 -
附件一 生產履歷系統應用成效評估之權重問卷(公司內部人員使用) - 68 -
附件二 生產履歷系統應用成效評估之問卷 - 76 -
表目錄
表1-1 我國生技產業與產品/服務關聯 - 2 -
表2-1生產履歷系統應用成效評估指標 - 14 -
表2-2 層級分析法評估尺度的意義 - 20 -
表2-3 隨機指標表 - 21 -
表3-1 生產履歷系統應用成效評估指標之彙總表 - 27 -
表4-1 個案公司的作業流程 - 32 -
表4-2生產履歷系統應用成效評估之權重問卷 受測者背景特性 - 35 -
表4-3 生產履歷系統應用成效評估之權重彙總表 - 43 -
表4-4 生產履歷系統評估之指標各問項之平均分數 - 45 -
表4-5 生產履歷系統應用成效之彙總表 - 47 -
表4-6 導入生產履歷系統預期問題與建議措施 - 61 -
圖目錄
圖1-1 2008~2009年我國生技廠商產值與成長率 - 1 -
圖1-2研究流程 - 5 -
圖2-3本體論之基本架構圖 - 13 -
圖3-1以本體論為基礎之生產履歷系統檔案之架構圖 - 23 -
圖3-2生產履歷系統之作業程序 - 24 -
圖4-1影響生產履歷系統評估指標以內部人員使用構面之架構圖 - 34 -
圖4-2 生產履歷系統應用成效評估權重值 - 36 -
圖4-3系統運作環境圖 - 49 -
圖4-4系統架構圖 - 49 -
圖4-5使用案例圖 - 51 -
圖4-6 類別圖 - 52 -
圖4-7 循序圖—公司人員使用生產履歷為例 - 53 -
圖4-8 循序圖—客戶使用生產履歷流程為例 - 54 -
圖4-9 生產履歷系統登入畫面 - 55 -
圖4-10原物料基本資料及原物料安全存量畫面 - 55 -
圖4-11進貨管理畫面 - 56 -
圖4-12原物料檢測畫面 - 56 -
圖4-13原物料COA法規值畫面 - 57 -
圖4-14產品基本資料及產品批號管理畫面 - 57 -
圖4-15產品檢驗畫面 - 58 -
圖4-16產品檢測法規值 - 58 -[[abstract]]國內目前生物科技產業蓬勃發展，基於生技產品的生產履歷資訊對消費者及生產者是十分重要的決策資訊來源。有鑒於此，本研究針對生技產業的需求，建立一套以本體論做為建立的生產履歷系統的依據，舉凡產品的生產從產地到消費者，都能留下完全歷程的電子紀錄並透過分類快速查詢，將所有的生產資訊公開與透明化，生產記錄可追溯性消費者保障制度，確保產品的安全性，使消費者對於產品的生產歷程與成分充分暸解並產生信心，據以提升市場競爭優勢。
本研究依據上述之本體論架構，再依循國際藥廠稽查公約組織(Pharmaceutical Inspection Convention and Pharmaceutical Inspection Co-operation Scheme, PIC/S)的規範，發展一套生產履歷系統提供資訊服務。本研究是以國內某一家生技公司為實證分析對象，問卷發放的對象是個案公司負責生產履歷作業人員，本研究是採用層級分析法（AHP）計算評估準則的權重值。因此，根據個案公司評估問卷結果，發現生產履歷系統的應用成效的主要因素為系統品質(63.6%)，其次是作業效益(25.5%)，最後是資訊及知識應用(10.9%)。本研究實際分析的結果，以本體論為基礎的生產履歷系統可以大幅度降低生產履歷的工作負荷與成本，提升作業品質與工作效率。同時，該系統可提供生產者與消費者完整的生產履歷資訊，作為決策之用途。
Recently with the development of biotechnological industries, both consumers and producers gradually pay more attention to the traceability information about products. Based on the needs of traceability information, this research develops an ontology-based traceability information system that aims to keeping the complete electronic records cover the information about the activities since the time from producers of raw materials to consumers. Therefore, consumers can access the traceability information about products very quickly. To ensure the safety of products, a traceability information system can provide consumers the traceability information about the biotechnological product openly and transparently. Consequently, producers will possess better competitive advantages due to providing consumers the transparent traceability information about products.
This research proposes a framework for developing an ontology-based traceability information system according to the procedures specified by the Pharmaceutical Inspection Convention and Pharmaceutical Inspection Co-operation Scheme (PIC/S). An empirical study is conducted in a biotechnology company in south Taiwan. Questionnaire respondents include persons in the survey company who manage the activities of traceability information about biotechnological products. The weights of evaluating criteria are computed using the AHP method. The findings of this research indicate that major factors affecting the application performance ranks as follows: system quality (63.6%), operational benefits (25.5%), and information and application knowledge (10.9%). In summary, an ontology-based traceability information system can be used to reduce the workload and reduction of total costs, and improve the quality of work and its efficiency. Besides, a traceability information system can provide comprehensive traceability information to producers and consumers for making a better purchase decision
Li Yu xi qu zhong de li shi cheng xian yu min jian mian xiang
No full textM.Phil.As one of the most important playwrights in late imperial China, Li Yu and his plays have long been discussed by researchers. However, many of them have underestimated the significance of Li Yu’s double identity of being, simultaneously, a member of the literati and a professional playwright of the urban theatre. Focusing on the representations of history in Li Yu’s plays, this thesis aims to explore how he negotiated influence from the two identities in his works. It is argued that in most of these plays he managed to deliver his care for the commoner audience, including providing them with theatrical entertainment and a mirror of daily life during the Ming-Qing transition, while expressing his personal concerns and feelings as a literatus.There are seven chapters in this thesis. Chapter One reviews the research history on Li Yu in the past century and raises the above topic of negotiation in question. Chapter Two to Five focus on four of Li Yu’s plays in chronological order, namely Qingzhong pu, Qianzhong lu, Liang xumei and Wanli yuan. All of the four plays were written meticulously as a kind of history, local or national. These four chapters illustrate the ways in which Li Yu combined his personal feelings, reflections on history, empathy with the common people, and equally important, his dramatic artistry. In Chapter Six, Qilin ge and Niutou shan were treated as examples of how popular legends about heroic figures in history such as Qin Qiong and Yue Yun were recreated by Li Yu for the commercial urban theatre in Suzhou. Chapter seven concludes the above discussions.The personal feelings and social cares shown in Li Yu’s plays came from real-life issues. Li not only recorded historical changes and social problems of his time, but also expressed his attitude towards the Qing government after the fall of Ming. By examining Li Yu’s attitude, this research also sheds light on Li Yu’s state of mind in later life, which has seldom been mentioned in the study of this dramatist.李玉（約1611-1677）為明末清初最重要的劇作家之一，學界對其近一世紀的研究已有豐碩成果，然而關於李玉文人與職業劇作家雙重身分對其創作的影響卻未有詳細的討論。故此，本文將視野聚焦在李玉劇作中對歷史的呈現，從文本內部、觀眾接受、外在社會情況等方面，探討其雙重身分在呈現兩種不同的目的與關注時之協調，發掘劇中所寄託的個人情感與民間面向，並觀察當中的變化。本文第一章梳理李玉研究之發展脈絡，提出個人關注的問題。第二至第五章按脫稿時間之先後，分章討論《清忠譜》、《千忠錄》、《兩鬚眉》、《萬裡圓》四部「以曲為史」之作所寄託之個人感懷與反思，及當中所體現的對民間之關懷。第六章以《麒麟閣》與《牛頭山》為李玉以歷史故事入劇之代表，探討李玉如何以劇場重現著名歷史故事，為民間觀眾提供娛樂。第七章就前述各劇之間的內部聯繫，及李玉個人心境與民間面向的變化軌跡作總結。李玉劇作中的個人寄託與對民間的關懷來自對現實的關注。它們不僅見證其身處的時代與社會之轉變，入清後之作更承載個人對易代、對清廷態度的變化。本文欲藉對李玉心態之剖析，填補學界對其後半生心境變化討論上的空白，加深對李玉其人的認識，亦為李玉研究提出就其身分與心態作進一步發展的新方向。劉美宜.Thesis M.Phil. Chinese University of Hong Kong 2017.Includes bibliographical references (leaves 162-173).Abstracts in English and Chinese.Title from PDF title page (viewed on February 17, 2020).Liu Meiyi
Negative Affect and Impulsivity in Adolescents with Non-Suicidal Self-Injury: The Moderating and Mediating Roles of Perceived Social Support
No full textBing Pan,1 Yun Gong,2 Meiyi Guo,3 Xiaohua Wang,1 Haitao Lu,1 Zheng Lin,1 Bingren Zhang3 1Department of Psychiatry, Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, 310009, People’s Republic of China; 2Department of Pediatrics, Hangzhou First People’s Hospital, Hangzhou, 310009, People’s Republic of China; 3Department of Medical Psychology, Affiliated Hospital (School of Clinical Medicine), Hangzhou Normal University, Hangzhou, 311121, People’s Republic of ChinaCorrespondence: Bingren Zhang, Department of Medical Psychology, Affiliated Hospital (School of Clinical Medicine), Hangzhou Normal University, Hangzhou, People’s Republic of China, Tel +13757148402, Email [email protected] Zheng Lin, Department of Psychiatry, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of China, Tel +13757118261, Email [email protected]: Negative affective states and impulsivity have been found to be closely associated with non-suicidal self-injury (NSSI), but how negative affect contributes to impulsivity in NSSI adolescents and the role of perceived social support remain unclear.Methods: In Study 1, the Barratt Impulsiveness Scale (BIS-11) was administered on 225 NSSI adolescents and 225 healthy volunteers to determine the characteristics of impulsivity in the patients. In Study 2, 102 of the patients were randomly selected to further complete the Zung Self-rating Anxiety Scale (SAS), Zung Self-rating Depression Scale (SDS), and Multidimensional Scale of Perceived Social Support (MSPSS) to clarify the relationships between negative affect, perceived social support, and impulsivity in these patients.Results: In Study 1, NSSI adolescents scored higher than volunteers on almost all factors of BIS-11 except for Cognitive Instability. In Study 2, Support from significant others mediated the association between SAS and BIS-11 Self-control. Moreover, Support from significant others and family moderated the prediction of SAS score on their BIS-11 Cognitive Complexity.Conclusion: Compared to healthy adolescents, NSSI individuals were more impulsive, while perceived support from family and significant others prevented the anxious NSSI adolescents from lower cognitive complexity. Therefore, more social support should be available to NSSI adolescents with high anxiety to reduce their risk of self-harm due to high impulsivity.Keywords: adolescents, impulsivity, negative affect, non-suicidal self-injury, perceived social suppor
Erika Tan, Halimah-the-Empire-Exhibition-weaver-who-died-whilst-performing-her-craft
No full textUnfolding over a period of three weeks is a special project by London based, Artist-in-Residence Erika Tan (Singapore). Focusing on the forgotten historical figure of Halimah the Malay weaver, Tan will revive her through a series of footnotes and instigate a process of collective labour towards the understanding that history is an effort built by many.
Halimah lived and worked with 19 other Malayans in the 1924 Empire Exhibition in London essentially engaging not only in the production of woven material but also symbolically reproducing Britain’s capital (its colonial subjects). During the day Halimah demonstrated her craft and sold products on one side of the Malayan Pavilion and at night lived behind the displays, cooking, eating and performing everyday life.
This project seeks to liberate Halimah from her textual existence and re-insert her into a contemporary dialogue around nation, art and value – or place, labour, capital. The Lab will be used in a triad of layers – as an exhibition space, a film studio and the site of a live “broadcast” debate with debaters, Meiyi Chan, Annabel Tan, Loh An Lin, Abigail Wong, Sara Ng and Geetha Creffield. They will be joined by filmmakers Lor Huiyun and Jolinna Ang
Progress in the development of mRNA vaccine and its delivery systems for anti-tumor immunotherapy
No full textDue to the drawbacks of low specificity and high risk of side effects of traditional anti-tumor treatments in clinical practice, novel anti-tumor immunotherapy has received attention and has been gradually applied. Tumor immunotherapy is to enhance the anti-tumor immune response by regulating the body’s immune system in order to achieve control and killing of tumors. Tumor immunotherapies include immune checkpoint blockade therapy, over-the-counter cellular immunotherapy and tumor vaccines. Among them, the tumor vaccine stimulates the immune system to produce specific immune cells or antibodies by delivering tumor cell-specific antigens thereby eliminating the tumor cells for the purpose of treating the tumor. In recent years, The field of mRNA vaccines is developing rapidly, and the required mRNA in the synthesis and preparation of the process has been developed and matured, laying a good foundation for the research of tumor mRNA vaccine. Because of the fact that mRNA is easily degraded and cannot enter the cell autonomously, this vaccine requires a suitable delivery vehicle to be successfully taken up by the cell to be effective. Therefore, the development of mRNA vaccine delivery systems has become critical for their better utilization, which is also an important part of whether mRNA vaccines can be developed and utilized for the clinical stage in the field of tumor therapy. This paper briefly introduced the immunotherapeutic methods for tumors, types of tumor vaccines and the mechanism of action and preparation methods of tumor mRNA vaccines, reviewed the research progress and related applications of mRNA vaccines and their common delivery systems in immunotherapy for tumor treatment, and summarized the tumor mRNA vaccines that entered into the phase of clinical trials with the aim of providing assistance for the research of mRNA vaccines for tumors in the future
and TMI Oxidations Are Important Mechanisms of Airborne Sulfate Aerosol Formation in Beijing, China during the Haze Event: Evidence by Sulfur Isotope Techniques
No full text
