426,299 research outputs found
Rathalos treecko Lin & Zhao & Koh & Li 2022, comb. nov.
No full textRathalos treecko (Lin & Li, 2021) comb. nov. Anyphaena treecko Lin & Li, In: Lin et al., 2021: 101, figs 9A–C, 10A–B, 14I–J. Material examined. Holotype ♂ (IZCAS-Ar42404), China: Hainan, Changjiang County, Bawangling, Dongsizhan (19.0495°N, 109.1157°E), 23 April 2009, G. Tang leg. (examined). Paratypes. 2♀ (IZCAS-Ar42405–Ar42406), same data as holotype (examined). Diagnosis. See Lin et al. (2021). Description. See Lin et al. (2021). Distribution. China (Hainan). Comments. The cymbial apophysis, the triangular epigyne and the straight copulatory duct indicate that this species belongs to Rathalos Lin & Li, gen. nov. Thus, we transfer it from Anyphaena to Rathalos Lin & Li, gen. nov.Published as part of Lin, Yejie, Zhao, Huifeng, Koh, Joseph K H & Li, Shuqiang, 2022, Taxonomy notes on twenty-eight spider species (Arachnida: Araneae) from Asia, pp. 198-270 in Zoological Systematics 47 (3) on page 201, DOI: 10.11865/zs.2022303, http://zenodo.org/record/717585
Study on the phase separation of La0.7Sr0.3MnO3 nanoparticles by electron magnetic resonance
No full textThe stem cell E3-ligase Lin-41 promotes liver cancer progression through inhibition of microRNA-mediated gene silencing
No full textLin-41 is a stem cell-specific E3 ligase and a known target of the tumour suppressor microRNA (miRNA) let-7. Lin-41 was recently reported to mediate ubiquitylation and degradation of the miRNA pathway protein Ago2. We demonstrate that Lin-41 is over-expressed in hepatocellular carcinoma (HCC). Lin-41 over-expression correlates with high a-fetoprotein level, high tumour grade and high tumour stage and predicts early tumour recurrence. Lin-41 is a strong predictor of poor long-term survival for patients with HCC. Lin-41 knock-down by RNA interference in HCC cell lines Huh7 and Hep3B suppressed proliferation in vitro and reduced in vivo tumour growth in NOD/SCID mice. On the other hand, over-expression of Lin-41 in the HCC cell line SK-Hep1 enhanced tumourigenicity. Over-expression and knock-down of Lin-41 led to inverse changes in the levels of Ago1 and Ago2 proteins. Over-expression of Ago1 and Ago2 reduced in vivo tumour growth. Lin-41 over-expression suppressed let-7 activity in HCC cell lines and expression of Lin-41 enhanced the expression of let-7-regulated oncogenes c-Myc, Lin-28B, HMGA2 and type 1 insulin-like growth factor receptor (IGF1R). Expression of Lin-28B and c-Myc enhanced the expression of Lin-41. Chromatin immunoprecipitation and reporter assays revealed direct association of c-Myc with the Lin-41 promoter, resulting in transcriptional transactivation. Our results indicate that Lin-41 plays an important role in the growth of HCC by regulating RISC complex proteins Ago1 and Ago2 to inhibit miRNA-mediated gene silencing and promote the expression of oncogenic proteins. Lin-41 is also a strong prognostic factor for patients with HCC. Copyright (C) 2012 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd
A Population-Based Study on the Association between Gastric Ulcers and Erectile Dysfunction in Taiwan
No full textIntroduction. While erectile dysfunction (ED) and cardiovascular disease have long been known to share endothelial dysfunction as a common contributory underlying mechanism, little research has been conducted taking endothelial dysfunction as common ground to investigate the potential association between ED and gastric ulcers (GUs). ;Aim. This population-based case-control study aimed to investigate the association of ED with GU. ;Methods. This study used data from the Longitudinal Health Insurance Database 2000 in Taiwan. The study group comprised 6,906 patients who visited ambulatory care centers or were hospitalized with a diagnosis of ED. The comparison group was 20,718 randomly selected enrollees. Conditional logistic regression was used to examine associations between ED and prior GU. ;Main Outcome Measure. The prevalence and risk between cases and controls were calculated of having been previously diagnosed with GU. ;Results. Of the sampled subjects, 3,861 (14%) were diagnosed before the index date, 1,358 (19.7%) were cases, and 2,503 (12.1%) were controls (P < 0.001). After adjusting for hypertension, diabetes, hyperlipidemia, renal disease, coronary heart disease, obesity, alcohol abuse/alcohol dependence syndrome, and socioeconomic status (SES), conditional logistic regression analysis revealed that cases were more likely to have been diagnosed with GU than controls (odds ratio [OR] = 1.65, 95% confidence interval [CI] = 1.53-1.77). Stratification by age revealed that the youngest group (18-29) of ED patients had the most increased likelihood of having been previously diagnosed with GU when compared with matched controls (OR = 4.12, 95% CI = 2.41-7.03). The likelihood decreased with age, with the oldest group of ED patients having the least increased likelihood of prior GU when compared with matched controls (OR = 1.44, 95% CI = 1.23-1.68). ;Conclusion. Our findings suggest a positive association between prior GU and a subsequent diagnosis with ED. Keller JJ, Lin H-Yu, Chung S-D, and Lin H-C. A population-based study on the association between gastric ulcers and erectile dysfunction in Taiwan. J Sex Med 2012; 9: 686-693
LIN-2 and FRM-3 regulate the synaptic abundance but not surface expression level of AChRs.
No full text(A-D) ACR-16::RFP and UNC-29::RFP synaptic abundance were decreased in lin-2null and frm-3null mutants. Representative images (A, C, scale bar 10 μm) and mean puncta intensity (B, D) are shown. The wild type is normalized to 1. (E-H) ACh- and Levamisole-activated currents were unaltered in lin-2null and frm-3null mutants. Representative traces (E, G) and mean current amplitude (F, H) are shown. (I, J) GABA-activated currents were decreased by 50% in lin-2null mutants but were unchanged in frm-3null mutants. Data are mean ± SEM (***, p < 0.001 when compared to control; one-way ANOVA). The number of worms analyzed for each genotype is indicated in the bar.</p
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