308,429 research outputs found
The stem cell E3-ligase Lin-41 promotes liver cancer progression through inhibition of microRNA-mediated gene silencing
No full textLin-41 is a stem cell-specific E3 ligase and a known target of the tumour suppressor microRNA (miRNA) let-7. Lin-41 was recently reported to mediate ubiquitylation and degradation of the miRNA pathway protein Ago2. We demonstrate that Lin-41 is over-expressed in hepatocellular carcinoma (HCC). Lin-41 over-expression correlates with high a-fetoprotein level, high tumour grade and high tumour stage and predicts early tumour recurrence. Lin-41 is a strong predictor of poor long-term survival for patients with HCC. Lin-41 knock-down by RNA interference in HCC cell lines Huh7 and Hep3B suppressed proliferation in vitro and reduced in vivo tumour growth in NOD/SCID mice. On the other hand, over-expression of Lin-41 in the HCC cell line SK-Hep1 enhanced tumourigenicity. Over-expression and knock-down of Lin-41 led to inverse changes in the levels of Ago1 and Ago2 proteins. Over-expression of Ago1 and Ago2 reduced in vivo tumour growth. Lin-41 over-expression suppressed let-7 activity in HCC cell lines and expression of Lin-41 enhanced the expression of let-7-regulated oncogenes c-Myc, Lin-28B, HMGA2 and type 1 insulin-like growth factor receptor (IGF1R). Expression of Lin-28B and c-Myc enhanced the expression of Lin-41. Chromatin immunoprecipitation and reporter assays revealed direct association of c-Myc with the Lin-41 promoter, resulting in transcriptional transactivation. Our results indicate that Lin-41 plays an important role in the growth of HCC by regulating RISC complex proteins Ago1 and Ago2 to inhibit miRNA-mediated gene silencing and promote the expression of oncogenic proteins. Lin-41 is also a strong prognostic factor for patients with HCC. Copyright (C) 2012 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd
[Report to Chief J. E. Curry, by an unknown author #1]
No full textReport to Chief J. E. Curry, by an unknown author. The report contains a list of officers who gave depositions to the United States Attorney
[Report to Chief J. E. Curry, by an unknown author #2]
No full textReport to Chief J. E. Curry, by an unknown author. The report contains a list of officers who gave depositions to the United States Attorney
Spatial Chow-Lin Methods for Data Completion in Econometric Flow Models
Full text linkFlow data across regions can be modeled by spatial econometric models, see LeSage and Pace (2009). Recently, regional studies became interested in the aggregation and disaggregation of flow models, because trade data cannot be obtained at a disaggregated level but data are published on an aggregate level. Furthermore, missing data in disaggregated flow models occur quite often since detailed measurements are often not possible at all observation points in time and space. In this paper we develop classical and Bayesian methods to complete flow data. The Chow and Lin (1971) method was developed for completing disaggregated incomplete time series data. We will extend this method in a general framework to spatially correlated flow data using the cross-sectional Chow-Lin method of Polasek et al. (2009). The missing disaggregated data can be obtained either by feasible GLS prediction or by a Bayesian (posterior) predictive density.Missing values in spatial econometrics, MCMC, non-spatial Chow-Lin (CL) and spatial Chow-Lin (SCL) methods, spatial internal flow (SIF) models, origin and destination (OD) data
A Population-Based Study on the Association between Gastric Ulcers and Erectile Dysfunction in Taiwan
No full textIntroduction. While erectile dysfunction (ED) and cardiovascular disease have long been known to share endothelial dysfunction as a common contributory underlying mechanism, little research has been conducted taking endothelial dysfunction as common ground to investigate the potential association between ED and gastric ulcers (GUs). ;Aim. This population-based case-control study aimed to investigate the association of ED with GU. ;Methods. This study used data from the Longitudinal Health Insurance Database 2000 in Taiwan. The study group comprised 6,906 patients who visited ambulatory care centers or were hospitalized with a diagnosis of ED. The comparison group was 20,718 randomly selected enrollees. Conditional logistic regression was used to examine associations between ED and prior GU. ;Main Outcome Measure. The prevalence and risk between cases and controls were calculated of having been previously diagnosed with GU. ;Results. Of the sampled subjects, 3,861 (14%) were diagnosed before the index date, 1,358 (19.7%) were cases, and 2,503 (12.1%) were controls (P < 0.001). After adjusting for hypertension, diabetes, hyperlipidemia, renal disease, coronary heart disease, obesity, alcohol abuse/alcohol dependence syndrome, and socioeconomic status (SES), conditional logistic regression analysis revealed that cases were more likely to have been diagnosed with GU than controls (odds ratio [OR] = 1.65, 95% confidence interval [CI] = 1.53-1.77). Stratification by age revealed that the youngest group (18-29) of ED patients had the most increased likelihood of having been previously diagnosed with GU when compared with matched controls (OR = 4.12, 95% CI = 2.41-7.03). The likelihood decreased with age, with the oldest group of ED patients having the least increased likelihood of prior GU when compared with matched controls (OR = 1.44, 95% CI = 1.23-1.68). ;Conclusion. Our findings suggest a positive association between prior GU and a subsequent diagnosis with ED. Keller JJ, Lin H-Yu, Chung S-D, and Lin H-C. A population-based study on the association between gastric ulcers and erectile dysfunction in Taiwan. J Sex Med 2012; 9: 686-693
A fuzzy approach for sequencing interrelated activities in a DSM
No full textProduction and manufacturing systems often involve a myriad of interrelated activities. How these activities are organised and scheduled has a significant effect on the success of a system. Recently, the Design Structure Matrix (DSM) has been regarded as an effective tool for modelling and scheduling interrelated activities. Based on fuzzy set theory, this study explicitly addresses the uncertain activity dependencies in our formulation and develops a mathematical model for sequencing interrelated activities in a DSM. Because of the complexity of the model, a new approach, which embeds an exact algorithm within a framework of a local search heuristic, is presented for solving large problem instances. Testing results demonstrate that relatively good solutions can be easily obtained by our approach, thereby providing managers with an effective tool for scheduling a large number of interrelated activities with uncertain dependencies. © 2012 Copyright Taylor and Francis Group, LLC.Abdelsalam HME, 2006, IEEE T ENG MANAGE, V53, P69, DOI 10.1109-TEM.2005.861805; Ahmadi R, 2001, EUR J OPER RES, V130, P539, DOI 10.1016-S0377-2217(99)00412-9; Banerjee A, 2007, IIE TRANS, V39, P453, DOI 10.1080-07408170601180510; Browning TR, 2001, IEEE T ENG MANAGE, V48, P292, DOI 10.1109-17.946528; Chen CH, 2004, INT J PROD RES, V42, P4623, DOI 10.1080-00207540410001721727; Chen SJ, 2003, COMPUT IND ENG, V44, P435, DOI 10.1016-S0360-8352(02)00230-9; Debels D, 2007, OPER RES, V55, P457, DOI 10.1287-opre.1060.0358; Dubois D., 2000, FUNDAMENTALS FUZZY S; Dubois D, 2003, EUR J OPER RES, V147, P231, DOI 10.1016-S0377-2217(02)00558-1; EPPINGER SD, 1994, RES ENG DES, V6, P1, DOI 10.1007-BF01588087; Eppinger SD, 2001, HARVARD BUS REV, V79, P149; Fortemps P, 1996, FUZZY SET SYST, V82, P319, DOI 10.1016-0165-0114(95)00273-1; Guschinskaya O, 2008, EUR J OPER RES, V189, P902, DOI 10.1016-j.ejor.2006.03.072; Karniel A, 2009, IEEE T ENG MANAGE, V56, P636, DOI 10.1109-TEM.2009.2032032; Karniel A, 2005, COMPUT AIDED DESIGN, V37, P399, DOI 10.1016-j.cad.2004.06.015; KUSIAK A, 1993, INT J PROD RES, V31, P753, DOI 10.1080-00207549308956755; Lancaster J, 2008, INT J PROD RES, V46, P5043, DOI 10.1080-00207540701324176; Li D., 2006, NONLINEAR INTEGER PR; Lin J, 2009, EUR J OPER RES, V196, P1158, DOI 10.1016-j.ejor.2008.05.030; Lin J, 2010, EUR J OPER RES, V201, P737, DOI 10.1016-j.ejor.2009.03.040; Lin J, 2008, EUR J OPER RES, V185, P378, DOI 10.1016-j.ejor.2006.12.022; Luh DB, 2009, CONCURRENT ENG-RES A, V17, P43, DOI 10.1177-1063293X09102249; McCulley C, 1996, STRUCT OPTIMIZATION, V12, P186, DOI 10.1007-BF01196956; Meier C, 2007, J MECH DESIGN, V129, P566, DOI 10.1115-1.2717224; Palpant M, 2004, ANN OPER RES, V131, P237, DOI 10.1023-B:ANOR.0000039521.26237.62; Qian YJ, 2011, IEEE T ENG MANAGE, V58, P688, DOI 10.1109-TEM.2011.2107558; Rowles C. M., 1999, THESIS MIT; Shaja AS, 2010, RES ENG DES, V21, P173, DOI 10.1007-s00163-009-0082-5; Smith RP, 1997, MANAGE SCI, V43, P1104, DOI 10.1287-mnsc.43.8.1104; Smith RP, 1998, CONCURRENT ENG-RES A, V6, P15, DOI 10.1177-1063293X9800600103; Steward D. V., 1981, IEEE T ENG MANAGE, V49, P428; Tang DB, 2010, ADV ENG INFORM, V24, P159, DOI 10.1016-j.aei.2009.08.005; Tang DB, 2000, COMPUT IND ENG, V38, P479, DOI 10.1016-S0360-8352(00)00059-0; Tang DB, 2009, CONCURRENT ENG-RES A, V17, P129, DOI 10.1177-1063293X09105348; YAGER RR, 1981, INFORM SCIENCES, V24, P143, DOI 10.1016-0020-0255(81)90017-7; Yassine A, 2003, CONCURRENT ENG-RES A, V11, P165, DOI 10.1177-106329303034503; Zimmermann H.-J., 1996, FUZZY SET THEORY ITS32
Nutrient-limited growth with non-linear cell diffusion as a mechanism for floral pattern formation in yeast biofilms
Full text linkAvailable online 7 April 2018Abstract not availableAlexander Tam, J. Edward F. Green, Sanjeeva Balasuriya, Ee Lin Tek, Jennifer M. Gardner, Joanna F. Sundstrom, Vladimir Jiranek, Benjamin J. Binde
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