6,468 research outputs found
Seasonal-variation of the activity and range use patterns of a wild troop of Formosan macaque in Kenting, Taiwan.
No full textIs STAT3 and PTEN expression altered in canine prostate cancer?
No full textSignal transducer and activator of transcription 3 (STAT3) and phosphatase and tensin homologue (PTEN) are, respectively, an oncogene and tumour suppressor gene whose dysregulated expression in human prostate cancer is associated with increased malignancy and poor prognosis. Both markers were evaluated in 12 samples of canine benign prostatic hyperplasia (BPH) and 17 canine prostatic carcinomas (PCs) by immunohistochemistry, to understand their possible role in canine prostate carcinogenesis. STAT3 was expressed in 25% and 82.35% of BPH and PC, respectively, with a significantly higher number of STAT3-positive cells in malignant compared with hyperplastic lesions. Three PCs had occasional nuclear expression of STAT3. PTEN was expressed in BPH and PC with a similar distribution and percentage of positive cells; however, four PCs were PTEN negative. Solid PCs contained more STAT3-positive and fewer PTEN-positive cells compared with the other subtypes. A reduced number of PTEN-positive cells was observed in PCs with a high Gleason score (GS10), while no association was demonstrated between STAT3 expression and Gleason score. The data suggest that overexpression of STAT3 and downregulation of PTEN may be an important step in canine prostate carcinogenesis and both markers may be related to the histological subtypes of PC and the degree of differentiation of neoplastic cells
Lysophosphatidic acid induced oxidized LDL uptake is class A scavenger receptor dependent in mouse macrophages.
No full textThe fine structure of somatotrophs and corticotrophs in the adenohypophysis of the golden hamster.
No full textLysophospholipids increase ICAM-1 expression in human umbilical cord vein endothelial cells through a Gi- and NFkB-dependent mechanism.
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The RGM/DRAGON family of BMP co-receptors.
No full textThe BMP signaling pathway controls a number of cell processes during development and in adult tissues. At the cellular level, ligands of the BMP family act by binding a hetero-tetrameric signaling complex, composed of two type I and two type If receptors. BMP ligands make use of a limited number of receptors, which in turn activate a common signal transduction cascade at the intracellular level. A complex regulatory network is required in order to activate the signaling cascade at proper times and locations, and to generate specific downstream effects in the appropriate cellular context
Vibrational and rotational energy transfers involving the CHB (2)Sigma(-) v=1 vibrational level in collisions with Ar, CO, and N2O
No full textInducible heat shock protein 70, interleukin-18, and tumor necrosis factor alfa correlate with outcomes in spontaneous intracranial hemorrhage.
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