408 research outputs found
Forecasting banknotes
No full textA central bank’s liquidity forecast is important in ensuring that it supplies the banking system’s need for central bank money. Banknote (or currency in circulation) demand is the largest and for some central banks the most variable component of the liquidity forecast. Accurate forecasting of banknotes is essential in ensuring an accurate liquidity forecast and in turn effective monetary policy implementation. This Handbook discusses these issues and outlines a structural time series state space (STSSS) model which is now used by central banks including the Bank of England and ECB to forecast banknotes (currency in circulation).Forecasting banknotes
Abstract 4964: Structure, in vitro biology and in vivo pharmacodynamic characterization of a novel clinical IDO1 inhibitor
No full textAbstract
The enzyme indoleamine 2,3-dioxygenase 1 (IDO1) catalyzes the degradation of tryptophan along the kynurenine pathway, and is frequently expressed in human malignancies. The activity of IDO1 induces an immunosuppressive microenvironment in tissues by inhibiting T-cell function through local depletion of tryptophan and through generation of kynurenine pathway metabolites. Inhibition of IDO1 is expected to diminish the immunosuppressive tumor microenvironment and improve cancer patient outcomes, particularly when used in combination with cancer immunotherapy agents such as nivolumab and ipilimumab. In this presentation, we will disclose the chemical structure, enzyme inhibitory mechanism, in vitro potency and in vivo pharmacodynamic (PD) activity of BMS’ IDO1 inhibitor currently in Phase I clinical trials. The compound is a potent and selective IDO1 inhibitor with no activity against another tryptophan degrading enzyme, tryptophan 2,3-dioxygenase (TDO). It exhibited potent cellular activity, suppressing kynurenine production in HEK293 cells overexpressing human IDO1 (IC50 = 1.1 nM) and in HeLa cells stimulated with IFNγ (IC50 = 1.7 nM). The compound also potently restored T-cell proliferation in a co-culture of T cells and human cancer cells and in a mixed lymphocyte reaction where T cells were co-cultured with allogeneic IDO1-expressing dendritic cells (EC50 = 1.2 nM). In vivo, when given once a day orally, the compound exhibited significant PD activity in mouse tumors grown subcutaneously in syngeneic hosts and in human tumors grown as xenografts in nude mice.
Citation Format: John T. Hunt, Aaron Balog, Christine Huang, Tai-An Lin, Tai-An Lin, Derrick Maley, Johnni Gullo-Brown, Jesse Swanson, Jennifer Brown. Structure, in vitro biology and in vivo pharmacodynamic characterization of a novel clinical IDO1 inhibitor [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 4964. doi:10.1158/1538-7445.AM2017-4964</jats:p
Author Obliged to Submit Paper before 4 July: Policies in an Enterprise Specification
No full textAbstract Specifying policies doesn't occur in splendid isolation but as part of refining an enterprise specification. The roles, the tasks, and the business processes of an ODP community provide the basic alphabet over which we write our policies. We illustrate this through exploring a conference programme committee case study. We discuss how we might formulate policies and show how policies are refined alongside the refinement of the overall system specification, developing notions of sufficiency and necessity. Policy delegation is also discussed and we categorise different forms of delegating an obligation
On the fragmentation of furan molecule and its dependence on the laser wavelength
No full textThe fragmentation processes of the aromatic conjugated diene systems have been studied by many research groups [1–10]. Derrick et al. [1], have studied the electronic structure using photoelectron spectroscopy, where a number of highly excited Rydberg states were accessed, also they attributed the fragmentation of the furan molecule to the photoelectron energy responsible for the breaking of the C–C bond or the C–O bond. Rockwood et al. [10], using a fixed frequency KrF laser (249 nm), and Zandee and Bernstein [4], using nitrogen laser pumped dye laser, both found extensive ion fragmentation as the laser power density was increased. Cooper et al. [5] studied the fragmentation process of the benzene, pyrrole, and furan molecules using the resonantly enhanced multiphoton ionization technique; they stated that the fragmentation process for benzene was efficient at the highest laser power density 5 × 109 W/cm2, for furan molecule at a laser wavelength of 376 nm, in a two–photon resonance the parent ion was seen as the strongest peak, while at 550.5 nm in a three–photon resonance the parent ion was not seen in full laser power, and only appeared slightly at 54% of the laser power. Boesl et al. [6], in a work done on the fragmentation of furan, reported a weak dependence of the ion efficiency on wavelength
Reducing ethnic and geographic inequities to optimise New Zealand stroke care (REGIONS Care): Protocol for a nationwide observational study
No full text(c) The Author/sBackground: Stroke systems of care differ between larger urban and smaller rural settings and it is unclear to what extent this may impact on patient outcomes. Ethnicity influences stroke risk factors and care delivery as well as patient outcomes in nonstroke settings. Little is known about the impact of ethnicity on poststroke care, especially in Māori and Pacific populations.
Objective: Our goal is to describe the protocol for the Reducing Ethnic and Geographic Inequities to Optimise New Zealand Stroke Care (REGIONS Care) study.
Methods: This large, nationwide observational study assesses the impact of rurality and ethnicity on best practice stroke care access and outcomes involving all 28 New Zealand hospitals caring for stroke patients, by capturing every stroke patient admitted to hospital during the 2017-2018 study period. In addition, it explores current access barriers through consumer focus groups and consumer, carer, clinician, manager, and policy-maker surveys. It also assesses the economic impact of care provided at different types of hospitals and to patients of different ethnicities and explores the cost-efficacy of individual interventions and care bundles. Finally, it compares manual data collection to routine health administrative data and explores the feasibility of developing outcome models using only administrative data and the cost-efficacy of using additional manually collected registry data. Regarding sample size estimates, in Part 1, Study A, 2400 participants are needed to identify a 10% difference between up to four geographic subgroups at 90% power with an α value of .05 and 10% to 20% loss to follow-up. In Part 1, Study B, a sample of 7645 participants was expected to include an estimated 850 Māori and 419 Pacific patients and to provide over 90% and over 80% power, respectively. Regarding Part 2, 50% of the patient or carer surveys, 40 provider surveys, and 10 focus groups were needed to achieve saturation of themes. The main outcome is the modified Rankin Scale (mRS) score at 3 months. Secondary outcomes include mRS scores; EQ-5D-3L (5-dimension, 3-level EuroQol questionnaire) scores; stroke recurrence; vascular events; death; readmission at 3, 6, and 12 months; cost of care; and themes around access barriers.
Results: The study is underway, with national and institutional ethics approvals in place. A total of 2379 patients have been recruited for Part 1, Study A; 6837 patients have been recruited for Part 1, Study B; 10 focus groups have been conducted and 70 surveys have been completed in Part 2. Data collection has essentially been completed, including follow-up assessment; however, primary and secondary analyses, data linkage, data validation, and health economics analysis are still underway.
Conclusions: The methods of this study may provide the basis for future epidemiological studies that will guide care improvements in other countries and populations.
International Registered Report Identifier (IRRID): DERR1-10.2196/25374FALS
Scalar soliton quantization with generic moduli
No full textThis article is distributed under the terms of the Creative Commons
Attribution License (CC-BY 4.0), which permits any use, distribution and reproduction in
any medium, provided the original author(s) and source are credArticle funded by SCOAP3. CP is
a Royal Society Research Fellow and partly supported by the U.S. Department of Energy
under grants DOE-SC0010008, DOE-ARRA-SC0003883 and DOE-DE-SC0007897. ABR
is supported by the Mitchell Family Foundation. We would like to thank the Mitchell
Institute at Texas A&M and the NHETC at Rutgers University respectively for hospitality
during the course of this work. We would also like to acknowledge the Aspen Center
for Physics and NSF grant 1066293 for a stimulating research environment which led to
questions addressed in this paper
Microarray gene expression profilings tageting HSC based on relative comparison.
No full text<p>KLS: c-Kit+ Lin− Sca-1+; MPP: multipotent progenitor; CMP: common myeloid progenitor; CLP: common lymphoid progenitor; GMP: granulocyte/macrophage progenitor; MEP: megakaryocyte/erythrocyte progenitor; Pro T: progenitor T cell, Pro B: progenitor B cell.</p
Identifying trustworthy experts: How do policymakers find and assess public health researchers worth consulting or collaborating with?
No full textThis paper reports data from semi-structured interviews on how 26 Australian civil servants, ministers and ministerial advisors find and evaluate researchers with whom they wish to consult or collaborate. Policymakers valued researchers who had credibility across the three attributes seen as contributing to trustworthiness: competence (an exemplary academic reputation complemented by pragmatism, understanding of government processes, and effective collaboration and communication skills); integrity (independence, "authenticity", and faithful reporting of research); and benevolence (commitment to the policy reform agenda). The emphases given to these assessment criteria appeared to be shaped in part by policymakers' roles and the type and phase of policy development in which they were engaged. Policymakers are encouraged to reassess their methods for engaging researchers and to maximise information flow and support in these relationships. Researchers who wish to influence policy are advised to develop relationships across the policy community, but also to engage in other complementary strategies for promoting research-informed policy, including the strategic use of mass media
Monotonicity properties of oscillatory solutions of differential equation
No full textsummary:We obtain monotonicity results concerning the oscillatory solutions of the differential equation . The obtained results generalize the results given by the first author in [1] (1976). We also give some results concerning a special case of the above differential equation
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