896 research outputs found
Maternal high fat diet during pregnancy and lactation alters hepatic expression of insulin like growth factor-2 and key microRNAs in the adult offspring
Full text linkBackground :miRNAs play important roles in the regulation of gene functions. Maternal dietary modifications during pregnancy and gestation have long-term effects on the offspring, but it is not known whether a maternal high fat (HF) diet during pregnancy and lactation alters expression of key miRNAs in the offspring.Results: We studied the effects of maternal HF diet on the adult offspring by feeding mice with either a HF or a chow diet prior to conception, during pregnancy and lactation, and all offspring were weaned onto the same chow diet until adulthood. Maternal HF fed offspring had markedly increased hepatic mRNA levels of peroxisome proliferator activated receptor-alpha (ppar-alpha) and carnitine palmitoyl transferase-1a (cpt-1a) as well as insulin like growth factor-2 (Igf2). A HF diet induced up-regulation of ppar-alpha and cpt-1a expression in the wild type but not in Igf2 knock out mice. Furthermore, hepatic expression of let-7c was also reduced in maternal HF fed offspring. Among 579 miRNAs measured with microarray, ~23 miRNA levels were reduced by ~1.5-4.9-fold. Reduced expression of miR-709 (a highly expressed miRNA), miR-122, miR-192, miR-194, miR-26a, let-7a, let7b and let-7c, miR-494 and miR-483* (reduced by ~4.9 fold) was validated by qPCR. We found that methyl-CpG binding protein 2 was the common predicted target for miR-709, miR-let7s, miR-122, miR-194 and miR-26a using our own purpose-built computer program.Conclusion: Maternal HF feeding during pregnancy and lactation induced co-ordinated and long-lasting changes in expression of Igf2, fat metabolic genes and several important miRNAs in the offspring
Final seed germination rate of <i>R</i>. <i>nutans</i> seeds submerged at different elevations in the PR-DZ and PU-DZ.
No full textThe lowercase letters represent the differences between the final seed germination rates at different elevations in the PR-DZ, whereas the uppercase letters represent the differences between the final seed germination rates at different elevations in the PU-DZ. Bars with the same letter are not significantly different, whereas those with different letters are significantly different, p<0.05. ** Represents significant differences between the final seed germination rates at the same elevation between different WLFZs, p<0.05.</p
Zabójcze przymierze: Mimetyczna interpretacja Dz 5, 1‒11
No full textThis is an attempt of a mimetic interpretation of Acts 5:1‒11. The article juxtaposes the narrative of Ananias and Sapphira with the
story of the sudden death of Nadab and Abihu from Lev 10:1‒7. The Author argues that apart from situational resemblance, both passages are similar on a deeper level: they are set at the beginning of new orders. Ananias and Sapphira are Adam and Eve of the early Christian community and like them violate their marital unity. Since marriage has become a symbol of Christ’s faithful and loving relationship to humanity, the couple’s treacherous connivance constitutes the ‘original sin’ of Christianity. Nevertheless, as a sacrificial text, Acts 5:1‒11 has had a negative influence on Christian religiosity.Autorka podejmuje próbę mimetycznej interpretacji Dz 5,1‒11. W artykule opowiadanie o Ananiaszu i Safirze zostaje zestawione z historią nagłej śmierci Nadaba i Abihu z Kpł 10,1‒7. Autorka stwierdza, że poza sytuacyjnym podobieństwem oba teksty są podobne na głębszym poziomie: umiejscowione są u zarania nowego porządku. Ananiasz i Safira tworzą Adama i Ewę wczesnochrześcijańskiej wspólnoty i podobnie jak oni niszczą małżeńską jedność. Ze względu na to, że małżeństwo stało się symbolem wiernej, miłosnej relacji Chrystusa do ludzkości, oszukańcze współdziałanie pary małżeńskiej z Dz 5,1‒11 stanowi „grzech pierworodny” chrześcijaństwa. Tym niemniej, jako ofiarniczy tekst, Dz 5,1‒11 wywarł negatywny wpływ na chrześcijańską religijność
Els aplecs «ts» i «dz» en valencià. Una anàlisi des de la teoria de l'optimitat
Full text linkThis article intends to demonstrate that the final form of the clusters /ts/ and /dz/ in the Valencian dialect depends upon the behaviour of a series of universal principles referring to the syllabic structure. The author assumes that such restrictions are ranked on a language particular basis, according to the postulates of Optimality Theory (Prince & Smolensky 1993). Then, the outputs for the alveolar clusters will be the result of applying the constraint hierarchy to the set of possible candidates consistent with every input. The different results of the clusters /ts/ and /dz/ in Valencian, and this dialect' s divergences from other Catalan varieties are explained by the differences in the ranking of the principles which each variety presents
Comment on "Nash and Stackelberg solutions in a differential game model of capitalism"
Full text linkGame Theory;Capitalism
Intra-class correlations (ICC) estimates for MZ and DZ twin groups for whole CC DTI measures.
No full text<p><u>Notes:</u> MZ – monozygotic twins; DZ- Dizygotic twins; FA – Fractional anisotropy; MD- Mean diffusivity; RD- radial diffusivity; AD – Axial diffusivity; ICC- Intra-class correlations.</p><p>Intra-class correlations (ICC) estimates for MZ and DZ twin groups for whole CC DTI measures.</p
Intraclass correlation between MZ twin pairs and between DZ twin pairs.
No full textNo overlap between MZ and DZ correlations implies genetic influences on the traits. The intraclass correlation with traits controlling for sex and age is included in S1 Table. CI, confidence interval; DZ, dizygotic; MZ, monozygotic. The data and code underlying this figure can be found at https://doi.org/10.6084/m9.figshare.17054540.v1.</p
Environmental tax reform with vertical tax externalities.
Full text linkThe paper studies a regional environmental tax reform in a federal state. A region unilaterally improves the environmental quality by increasing its energy taxes. The regional government recycles the excess tax revenues by lowering either pre-existing distorting labor or capital taxes. This regional tax reform causes a vertical tax externality in the federal budget. We show how the nature of this externality depends on the environmental goal, the tax-recycling scenario, the initial local and federal tax shares, and the relative importance of the reforming region in the federal state. Simulations illustrate the effects for Belgium and US.Tax reform; Vertical Tax Externality; Federalism;
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