6,466 research outputs found

    Fertility defects in <i>lin-35</i> mutants are not maternal effect and are not strongly rescued by mating under moderate temperature stress.

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    (A) Mean brood size of fertile worms for each treatment. Presence or absence of maternally loaded lin-35(+)/LIN-35(+) indicated by M+/M- respectively; presence or absence of zygotically expressed lin-35(+) indicated by Z+/Z- respectively. Maternal load of lin-35(+) was not sufficient for fertility to be maintained in lin-35 M+Z- mutants at 26°C and zygotic expression of lin-35 in M-Z+ mutants rescued fertility loss in mutants at 26°C. M-Z- animals did not inherit any wild-type lin-35 products (protein or RNA) from their mother and did not have a wild-type copy of the lin-35 gene, M+Z- animals inherited lin-35 products from their mother but did not have a wild-type copy of the lin-35 gene, and M-Z+ did not inherit any wild-type lin-35 products (protein or RNA) from their mother but did have a wild-type copy of the lin-35 gene. * significantly different than wild type at the same temperature. P-value ≤ 0.05 using one-way ANOVA with Turkey correction. Error bars indicate ± SEM. (B) Mean brood size of fertile worms for each genotype under the different mating and growth conditions (continual growth of hermaphrodites at 20°C (blue) and continual growth at 26°C (red)). Mating with wild-type males did not significantly increase the brood size of lin-35 mutants expressing either somatic transgene at high temperature. * significantly different from same strain unmated at the same temperature. P-value ≤ 0.05 using students t-test. Error bars indicate ± SEM. For mated experiments, males were always grown to adulthood at 20°C and then mating occurred at the temperature of the hermaphrodite treatment.</p

    Process engineering developments in wine production Alternative technologies for tartrate stabilisation

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    Christopher B. Colby, Lin Lin Low, Jim Godden, Mark Gishen, Brian K. O'Neil

    Give growth and macroeconomic stability in Russia a chance - harden budgets by eliminating nonpayments

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    The authors analyze the links between Russia's disappointing growth performance in the second half of the 1990s, its costly and unsuccessful stabilization, the macroeconomic meltdown of 1998, and the spectacular rise of non-payments. Non-payments flourished in an environment of fundamental inconsistency between a macroeconomic policy geared at sharp disinflation, and a microeconomic policy of bailing enterprises out through soft budget constraints. Heavy untargeted implicit subsidies flowing through the non-payments system (amounting to 10 percent of GDP annually) have stifled growth, contributed to the August 1998 meltdown, through their impact on public debt, and have made at best a questionable contribution to equity. Dismantling this system must be a top priority, along with promoting enterprise restructuring and growth (by hardening budget constraints) and medium-term macroeconomic stability (by reducing the size of subsidies). Getting the government out of the non-payments system means settling all appropriately controlled budgetary expenditures on time, and in cash, and eschewing spending arrears, thereby setting an example for enterprises, and laying the groundwork for eliminating tax offsets at all levels of government, and insisting on cash tax payments. To stop energy-related subsidies, would require not only that the government pay its own energy bills on time, and in cash, but also that the energy monopolies be empowered to disconnect non-paying clients. This will enable the government to insist that the energy monopolies in turn pay their own taxes in full, and on time.Banks&Banking Reform,Public Sector Economics&Finance,Economic Theory&Research,Payment Systems&Infrastructure,Environmental Economics&Policies,Banks&Banking Reform,Environmental Economics&Policies,Municipal Financial Management,Public Sector Economics&Finance,Economic Theory&Research

    Catholic Comments Podcast.

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    Fr. Brian McCoy, S.J. discusses his ministry to aboriginal Australians. McCoy is an anthropologist and a scholar in residence at Creighton University this semester. He is also the author of the book, “Holding Men,” which studies health issues among aboriginal men

    Botulinum neurotoxin for head and neck disorders/ [edited by] Andrew Blitzer, Brian E. Benson, Diana N. Kirke

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    Includes bibliographical references and index"Senior author Dr. Andrew Blitzer is an internationally renowned pioneer on the use of botulinum neurotoxin for functional disorders, with unparalleled expertise on this topic. Joined by co-editors Brian Benson and Diana Kirke, with multidisciplinary contributors, Botulinum Neurotoxin for Head and Neck Disorders Second Edition fills a gap in the medical literature. The unique textbook focuses on the use of botulinum neurotoxins for functional disorders of the head and neck, though with some aesthetic indications. The second edition reflects the latest advances and understanding of existing and emerging applications for botulinum neurotoxins, including new treatment paradigms, revised pharmacology, and an updated review of the literature in all chapters. Twenty superbly illustrated chapters cover the management of hyperfunctional, pain, and hypersecretory syndromes of the head and neck. Hyperfunctional motor disorders are discussed in chapters focused on blepharospasm, facial dystonia, Meige syndrome, oromandibular dystonia, spasmodic dysphonia (laryngeal dystonia), and cervical dystonia. Specific treatment approaches for pain are addressed in chapters on migraine and chronic daily tension headaches, temporomandibular disorders, and trigeminal neuralgia. The treatment of autonomic nervous system disorders is covered in chapters dedicated to Frey syndrome, facial hyperhydrosis, and sialorrhea"--Pharmacology of Botulinum Neurotoxins / Muna I. Bitar, Nikita Kohli, Maya Samman, and Andrew Blitzer -- Botulinum Neurotoxin for Blepharospasm / Amit Patel, Andrew Blitzer, and Boris L. Bentsianov -- Botulinum Neurotoxin for Facial Dystonia / Scott M. Rickert, Amy P. Wu, and Andrew Blitzer Botulinum -- Neurotoxin for Meige Syndrome / Niv Mor and Andrew Blitzer -- Botulinum Neurotoxin for Oromandibular Dystonia / Daniel Novakovic and Ajay E. Chitkara -- Botulinum Neurotoxin for Spasmodic Dysphonia / Phillip C. Song, Lucian Sulica, and Andrew Blitzer -- Botulinum Neurotoxin for Cervical Dystonia / Tanya K. Meyer, Joel Guss, and Ronda E. Alexander -- Botulinum Neurotoxin for Hemifacial Spasm and Facial Synkinesis / Lesley French Childs, Daniel Novakovic, and Scott R. Gibbs -- Botulinum Neurotoxin for Hyperfunctional Facial Lines / Brian E. Benson, Diana N. Kirke, and Andrew Blitzer -- Botulinum Neurotoxin for Upper and Lower Esophageal Spasm / Nwanmegha Young and Brian E. Benson -- Botulinum Neurotoxin for Palatal Myoclonus / Ajay E. Chitkara, Catherine F. Sinclair, and Daniel Novakovic -- Botulinum Neurotoxin for Temporomandibular Disorders, Masseteric Hypertrophy, and Cosmetic Masseter Reduction / Michael Z. Lerner and Andrew Blitzer -- Botulinum Neurotoxin Therapy in the Laryngopharynx / Craig H. Zalvan, Phillip C. Song, Nwanmegha Young, and Andrew Blitzer -- Botulinum Neurotoxin for Migraine / Rachel Kaye, Jerome Schwartz, Brian E. Benson, and William J. Binder -- Botulinum Neurotoxin for Chronic Tension Headache / Nwanmegha Young and Brian E. Benson -- Botulinum Neurotoxin for Trigeminal Neuralgia / Elizabeth Guardiani, Andrew Blitzer, Lesley French Childs, and Ronda E. Alexander -- Botulinum Neurotoxin for Frey's Syndrome / Rachel Kaye, Andrew Blitzer, and Brian E. Benson -- Botulinum Neurotoxin for Facial Hyperhidrosis / Diana N. Kirke, Daniel Novakovic, and Andrew Blitzer -- Botulinum Neurotoxin for Sialorrhea / Brianna K. Crawley, Scott M. Rickert, Senja Tomovic, and Andrew Blitzer -- Botulinum Neurotoxin for Radiation-Induced Spasm and Pain / Diana N. Kirke, Brian E. Benson, and Tanya K. Meyer1 online resourc

    From Too Much to Too Little: How the central U.S. drought of 2012 evolved out of one of the most devastating floods on record in 2011

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    Introduction: Brian Fuchs, National Drought Mitigation Center Regional Drought Perspective: Natalie A. Umphlett, High Plains Regional Climate Center, Michael S. Timlin, Midwest Regional Climate Center, Brian Fuchs, National Drought Mitigation Center State Drought Perspectives — Colorado: Wendy Ryan and Nolan Doesken, Colorado Climate Center • Illinois: Jim Angel, Illinois State Water Survey • Indiana: Olivia Kellner, Indiana State Climate Office • Iowa: Harry J. Hillaker, Iowa Dept. of Agriculture & Land Stewardship • Kansas: Mary Knapp and Xiaomao Lin, Kansas State University • Kentucky: Stu Foster, Kentucky State Climate Office • Michigan: Jeff Andresen and Aaron Pollyea, Michigan State University • Minnesota: Greg Spoden, Minnesota Department of Natural Resources • Missouri: Pat Guinan, Missouri State Climate Office • Nebraska: Natalie A. Umphlett, High Plains Regional Climate Center, Brian Fuchs, National Drought Mitigation Center • North Dakota: Adnan Akyüz, North Dakota State Climate Office • Ohio: Jeffrey C. Rogers, The Ohio State University • South Dakota: Laura M. Edwards and Dennis Todey, South Dakota State University • Wyoming: Tony Bergantino, Wyoming State Climate Office Conclusion: Brian Fuchs, National Drought Mitigation Cente

    Supernova shrapnel: nearby supernovae and dust transport in the ISM

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    The last 2 decades have seen the proposal, detection, and confirmation of live ^60Fe radioisotopes from an extra-solar source on Earth, showing an event outside the Solar System directly delivered material to the Earth since its formation. This work examines the possible sources for the ^60Fe and models the passage of the material from its source through the Solar System to the ocean floor. We consider the production and deposition on Earth of isotopes with half-lives in the range 10^5 to 10^8 years that might provide signatures of nearby stellar explosions, extending previous analyses of Core-Collapse Supernovae (CCSNe) to include Electron-Capture Supernovae (ECSNe), Super-Asymptotic Giant Branch (SAGBs) stars, Thermonuclear/Type Ia Supernovae (TNSNe), and Kilonovae/Neutron Star Mergers (KNe). We revisit previous estimates of the ^60Fe and ^26Al signatures, and extend these estimates to include ^244Pu and ^53Mn. We show that (i) the ^60Fe yield rules out the TNSN and KN interpretations, (ii) the ^60Fe signals highly constrain a SAGB interpretation but do not completely them rule out, (iii) are consistent with a CCSN origin, and (iv) are highly compatible with an ECSN interpretation. We also examine various influences on the path of interstellar dust carrying ^60Fe from a SN through the Heliosphere, with the aim of estimating the final global distribution on the ocean floor. We study the influences of magnetic fields, angle of arrival, wind and ocean cycling of SN material on the concentrations at different locations. We find that the passage of SN material through the mesosphere/lower thermosphere (MLT) is the greatest influence on the final global distribution, with ocean cycling causing lesser alteration as the SN material sinks to the ocean floor. SN distance estimates in previous works that assumed a uniform distribution are a good approximation. Including the effects on surface distributions, we estimate a distance of 46^(+10)_(-6) pc for an ECSN progenitor. We note that the SN dust retains directional information to within 1^(circ) through its arrival in the inner Solar System, so that SN debris deposition on inert bodies such as the Moon will be anisotropic, and thus could in principle be used to infer directional information. Lastly, we examine the various influences on the path of dust within a SN remnant (SNR) to determine when/if the dust decouples from the plasma, how much it is sputtered, and where within the ejecta the dust is located. We find that the inclusion of Rayleigh-Taylor (R-T) instabilities are important in studying dust survival as R-T instabilities influence the location of the SN's reverse shock. We also find the presence of a magnetic field within the shocked ISM material will limit the passage of SN dust grains reflecting them or trapping within the heart of the SNR.Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2018-08-01The student, Brian Fry, accepted the attached license on 2016-07-04 at 15:08.The student, Brian Fry, submitted this Dissertation for approval on 2016-07-04 at 15:23.This Dissertation was approved for publication on 2016-07-08 at 16:47.DSpace SAF Submission Ingestion Package generated from Vireo submission #9750 on 2016-11-10 at 12:24:50Made available in DSpace on 2016-11-10T18:39:16Z (GMT). No. of bitstreams: 2 FRY-DISSERTATION-2016.pdf: 10656279 bytes, checksum: 4e1be1f79a71e1417f54d190dc1ba4e3 (MD5) LICENSE.txt: 4206 bytes, checksum: 2fa157ab76c1e3bf97094664353e401f (MD5) Previous issue date: 2016-07-08Embargo set by: Seth Robbins for item 95449 Lift date: 2018-11-10T18:39:22Z Reason: Author requested U of Illinois access only (OA after 2yrs) in Vireo ETD systemEmbargo set by: Seth Robbins for item 95449 Lift date: 2018-11-10T18:43:22Z Reason: Author requested U of Illinois access only (OA after 2yrs) in Vireo ETD systemU of I Only Restriction Lifted for Item 95449 on 2018-11-11T10:15:45Z

    Author Correction: Dental anomaly detection using intraoral photos via deep learning (Scientific Reports, (2022), 12, 1, (11577), 10.1038/s41598-022-15788-1)

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    In the original version of this Article Ronilo Ragodos, Tong Wang and Brian J. Howe were omitted as equally contributing authors. Tong Wang was omitted as an additional corresponding author. Correspondence and requests for materials should also be addressed to [email protected]. In addition, the Author Contributions section in this Article was incorrect.Fil: Ragodos, Ronilo. University of Iowa; Estados UnidosFil: Wang, Tong. University of Iowa; Estados UnidosFil: Padilla, Carmencita. University of the Philippines; FilipinasFil: Hecht, Jacqueline T.. University of Texas; Estados UnidosFil: Poletta, Fernando Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET; ArgentinaFil: Orioli, Ieda Maria. Universidade Federal do Rio de Janeiro; BrasilFil: Buxó, Carmen J.. Universidad de Puerto Rico; Puerto RicoFil: Butali, Azeez. University of Iowa; Estados UnidosFil: Valencia Ramirez, Consuelo. Clinica Noel; ColombiaFil: Restrepo Muñeton, Claudia. Clinica Noel; ColombiaFil: Wehby, George. University of Iowa; Estados UnidosFil: Weinberg, Seth M.. University of Pittsburgh; Estados Unidos. University of Pittsburgh at Johnstown; Estados UnidosFil: Marazita, Mary L.. University of Pittsburgh at Johnstown; Estados Unidos. University of Pittsburgh; Estados UnidosFil: Moreno Uribe, Lina M.. University of Iowa; Estados UnidosFil: Howe, Brian J.. University of Iowa; Estados Unido

    Using functional representation in the reducing ATPG search

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    Due to the character of the original source materials and the nature of batch digitization, quality control issues may be present in this document. Please report any quality issues you encounter to [email protected], referencing the URI of the item.Includes bibliographical references.Major advances in VLSI technology over the past ten years has made the problem of fault detection for circuits more difficult. As these circuits increase in size, the demand for a highly efficient Automatic Test Pattern Generation algorithm exists. The problem for most ATPG algorithms is in minimizing the vast redundant space in a highly reconvergent fanout circuit. All redundant stuck-at faults which occur, are due to this reconvergent fanout within a circuit. Reconvergent fanout introduces dependencies in the values which can be assigned to various nodes. The objective of deterministic ATPG is to simultaneously satisfy all dependencies in the logically modified circuit (modification due to the fault). It is the goal to more efficiently prove redundancy, so as to not waste valuable time searching for a test when one does not exist. This research uses partial functional calculation techniques in order to calculate whether or not it is possible to achieve a test, given a set of required values within the network. These functional calculations use Ordered Partial Decision Diagrams (OPDDS) which are an ordered set of partial expansion graphs, which represent the larger implicants of a function when there is too little memory for the entire representation. OPDD graphs help reduce the search space associated with generating a. test for stuck-at faults. By incorporating OPDD calculations into the ATPG algorithm, one is able to identify the redundancy quickly. When ATPG assigns a value to a node in the network, the function graph at that site is AND'ed with the function graphs representing all other value assignments in order to produce a single functional graph. This graph eliminates any input combinations which cannot simultaneously satisfy all assignments. The OPDD graph also aids in finding additional mandatory assignments which must occur that normal ATPG techniques did not find. By adding these additional assignments, the search space can be exponentially reduced before a decision needs to be made. This leads to proving the fault site either testable or untestable, more rapidly . These functional calculations are used in conjunction with an ATPG algorithm developed by S. Lin [181 for his master's thesis at Texas A&M University. The complete algorithm is performed on the ISCAS combinational benchmark circuits in order to evaluate its performance. These circuits were chosen so as to compare with other researchers, and were specifically selected due to their ability to defeat commercial and academic ATPG systems
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