3,262 research outputs found
hp-Tau interacts with the first and second LIM domains of PINCH.
No full text<p>A) LIMS-specific deletion mutations predict that LIM1 and 2 domains of PINCH1 bind to hp-Tau. Expression plasmids for mutants (ΔLIMS 1–5) and full-length PINCH each with a FLAG-tag were generated via a PCR based strategy. Neuronal lysates were immunoprecipitated with anti-FLAG antibody and reacted with A) anti-hp-Tau (AT8), B) Nck-2 or E) MAP2 antibodies. Arrows indicate immunoreactive bands. FL, full length; ΔLIM, delta LIM indicates the LIM domain that was deleted; FLAG, epitope N-DYKDDDDK-C tag; Nck2, cytoplasmic adaptor protein that interacts with PINCH LIM4; MAP2, microtubule associated protein-2.</p
Results of objective image analysis using LDCT and IR-HP-CT.
No full textResults of objective image analysis using LDCT and IR-HP-CT.</p
Subjective image quality scores of LDCT and IR-HP-CT scans.
No full textSubjective image quality scores of LDCT and IR-HP-CT scans.</p
Cardiac pulsation artifacts evident on LDCT and IR-HP-CT scans.
No full textIR-HP-CT was associated with a significant reduction in cardiac pulsation (P < 0.0001). The black squares are the means and the horizontal bars the 95% confidence intervals.</p
Various pulmonary lesions and cardiac pulsation artifacts detected on IR-HP-CT and LDCT.
No full text(A) Small bullae in both upper lobes (white arrows) and centrilobular emphysema in the right upper lobe (dotted circle). (B) Focal nodular consolidation with peripheral ground glass opacity in the subpleural area of the left upper lobe (paired black arrows). (C) A 3-mm-diameter ground glass opacity in the left upper lobe (paired white arrows). (D) IR-HP-CT revealed no cardiac pulsation (4 points), but LDCT was associated with blurring of both cardiac margins (2 points) at the time of cardiac pulsation (black arrowheads). Compared with IR-HP-CT, the LDCT scans exhibited bronchial wall and pulmonary vessel blurring artifacts attributed to cardiac pulsation in the pericardiac areas of both lung fields (dotted ovals).</p
The Impact of strategic implementation on the employees and contractors of the Hewlett-Packard Company.
No full textConducted within the global corporation of the Hewlett-Packard Company, (HP),this research examines employee and contractor responses to strategic implementation. The research environment is a relatively small UK group withinthe corporation that has continuously experienced significant change as new strategies were implemented. Employee and contractor responses to three separate cycles of change are analysed together with data drawn from the wider corporation by using a psychological contract framework, semi-structured interviewing, a research diary and secondary data from the literature and electronic sources. The research is essentially qualitative but draws on quantitative data where appropriate. A case study approach within an action research paradigm is the chosen methodology to allow consideration and triangulation of multiple sources of data relevant to the natural workplace setting. The research has confirmed a change from old or original psychological contracts to new contracts where employees and contractors are more insecure in, and more cynical of, their employment. This change is perceived as a
violation of their psychological contract and is causing employees and contractors to adopt a more mercenary approach to their employment with HP. The special bond between HP and its employees generated by the values and
egalitarian working environment created by its founders has been broken by new leadership. Acquisition of the Compaq Computer Company has further impacted employees and contractors resulting in declining morale and increasing scepticism about its proposed benefits. Indeed the very legitimacy of the acquisition and the leadership of HP are being questioned as HP changes to a new form. According to the founders, the values established that made HP successful in its first fifty years were expected to continue for at least another fifty years. This research shows how changing these values has collectively impacted
employees and contractors resulting in a major threat to the continuing existence of HP in its present form
Size-specific dose estimates in each volunteer using LDCT and IR-HP-CT.
No full textThe mean SSDE was significantly lower using IR-HP-CT (P < 0.001). The central box represents the values from the lower to upper quartile (25 to 75 percentile). The red squares are the means and the middle line represents the median.</p
A study on intergranular corrosion of laser treated alloy 600 by DL-EPR method and microscopic examination
No full textNi-base Alloy 600 has been widely used as a steam generator (SIG) tubing material in nuclear power plants because of its good mechanical and corrosion properties at high temperatures. However, degradations of SIG tubes due to intergranular attack (IGA) and intergranular stress corrosion cracking (IGSCC) during normal operation were frequently reported. in particular, Alloy 600 can be very susceptible to IGA/IGSCC in some sulfur-bearing environments by sensitization. In this paper, the beneficial effects of laser surface melting (LSM) to intergranular corrosion of the sensitized Alloy 600 is presented from the results of the double loop electrochemical potentiokinetic reactivation (DL-EPR) test. The DL-EPR test was performed in de-aerated 0.01 M H2SO4 + 20 ppm KSCN at a scan rate of 0.5 mV/sec at room temperature. The degree of sensitization (DOS) of the sensitized Alloy 600 measured from the DL-EPR test was considerably reduced by LSM. The sensitized Alloy 600 after LSM also exhibited a relatively low DOS, comparing with that of the sensitized but not laser treated Alloy 600. From the microscopic observation, it was found that the microstructural changes by the LSM process, especially changes in the precipitation behavior of grain boundary Cr-rich carbides, caused the improvement of resistance to intergranular corrosion of the laser treated Alloy 600. The resistance to IGSCC of the laser treated Alloy 600 in sulfur-bearing environments was also discussed from the results of measured DOS and microstructural examination
Double loop electrochemical potentiokinetic reactivation test of nickel-base alloy 600 surface-melted by a CO2 laser beam
No full textNi-base Alloy 600 has been widely used as a steam generator (S/G) tubing material in nuclear power plants because of its good mechanical and corrosion properties at high temperatures. However, degradations of S/G tubes due to intergranular attack (IGA) and intergranular stress corrosion cracking (IGSCC) during normal operation have been frequently reported. In particular, Alloy 600 can be very susceptible to IGA/IGSCC in some sulfur-bearing environments by sensitization. In this paper, the beneficial effects of laser surface melting (LSM) on intergranular corrosion of the sensitized Ahoy 600 is presented from the results of the double loop electrochemical potentiokinetic reactivation (DL-EPR) test. The DL-EPR test was performed in de-aerated 0.01 M H2SO4+20 ppm KSCN at a scan rate of 0.5 mV/sec at room temperature. The degree of sensitization (DOS) of the sensitized Alloy 600 measured from the DL-EPR test was considerably reduced by LSM. The sensitized Alloy 600 after LSM also exhibited a relatively low DOS, compared with that of the sensitized but not laser treated Alloy 600. From the microscopic observation, it was found that the microstructural changes brought about by the LSM process. especially changes in the precipitation behavior of grain boundary Cr-rich carbides, caused the improvement of resistance to intergranular corrosion of the laser treated Alloy 600. The resistance to IGSCC of the laser treated Alloy 600 in sulfur-bearing environments was also discussed from the results of measured DOS and microstructural examination
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